DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti‐DKK1 therapeutic DKN ‐01

Autor: Edward J. Jarman, Marta Horcas‐Lopez, Scott H. Waddell, Stephanie MacMaster, Konstantinos Gournopanos, Daniel Y. H. Soong, Kamila I. Musialik, Panagiota Tsokkou, Minn‐E Ng, William A. Cambridge, David H. Wilson, Michael H. Kagey, Walter Newman, Jeffrey W. Pollard, Luke Boulter

Publikováno v: Jarman, E, Horcas Lopez, M, Waddell, S, MacMaster, S, Gournopanos, K, Soong, D, I. Musialik, K, Tsokkou, P, Ng, M-E, Cambridge, W, Wilson, D, Kagey, M H, Newman, W, Pollard, J W & Boulter, L 2022, ' DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti-DKK1 therapeutic DKN-01 ', Liver International . https://doi.org/10.1111/liv.15383

Background and aims: Dickkopf-1 (DKK1) is associated with poor prognosis in intrahepatic cholangiocarcinoma (iCCA), but the mechanisms behind this are unclear. Here, we show that DKK1 plays an immune regulatory role in vivo and inhibition reduces tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668e3173330f4883253652784be38a86
https://doi.org/10.1111/liv.15383

Methods for macrophage differentiation and in vitro generation of human tumor associated-like macrophages

Autor: Lesley M. Forrester, Jeffrey W. Pollard, Martha Lopez-Yrigoyen, Marta Horcas-Lopez, Luca Cassetta, Esther Heideveld

Tumor-associated macrophages (TAMs) are becoming a promising target for cancer immunotherapy. Significant efforts have been made to study the detrimental role of TAMs both in vivo and in vitro. However, it remains challenging to isolate these macroph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c11b8fa76388cfb7accd6f63f75a8069
https://doi.org/10.1016/bs.mie.2019.10.005