Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Marta Gaburjakova"'
Autor:
Jana Gaburjakova, Marta Gaburjakova
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5409 (2023)
Dantrolene is an intra-cellularly acting skeletal muscle relaxant used for the treatment of the rare genetic disorder, malignant hyperthermia (MH). In most cases, MH susceptibility is caused by dysfunction of the skeletal ryanodine receptor (RyR1) ha
Externí odkaz:
https://doaj.org/article/ab768d699c3b4ce6a223dfb0bcd89b95
Autor:
Jana Gaburjakova, Marta Gaburjakova
Publikováno v:
Cells, Vol 11, Iss 5, p 868 (2022)
The sarcoplasmic reticulum (SR) in cardiac muscle is suggested to act as a dynamic storage for Zn2+ release and reuptake, albeit it is primarily implicated in the Ca2+ signaling required for the cardiac cycle. A large Ca2+ release from the SR is medi
Externí odkaz:
https://doaj.org/article/41e1991d34bf4ac9b8ad406bc80e41be
Publikováno v:
Pflugers Archiv : European journal of physiology. 472(12)
Many proteins are phosphorylated at more than one phosphorylation site to achieve precise tuning of protein function and/or integrate a multitude of signals into the activity of one protein. Increasing the number of phosphorylation sites significantl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89dd41cb8ef25989a74b32ca6671c3a5
https://pubmed.ncbi.nlm.nih.gov/33078311
https://pubmed.ncbi.nlm.nih.gov/33078311
Publikováno v:
Current Medicinal Chemistry. 25:1720-1728
Background: Clinical treatment of heart failure is still suffering from limited efficacy and unfavorable side effects. The recently developed group of agents, the myosin motor activators, act directly on cardiac myosin resulting in an increased force
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758f34075bdd8904bfb681bcf920fb2e
https://doi.org/10.2174/0929867325666171222164320
https://doi.org/10.2174/0929867325666171222164320
Autor:
Segev Barak, Marta Gaburjakova, Jana Gaburjakova, Saak V. Ovsepian, Daniela Jezova, Eliyahu Dremencov, Viera Kútna
Publikováno v:
Neuroscience Letters. 764:136194
Notwithstanding major advances in psychotherapeutics, their efficacy and specificity remain limited. The slow onset of beneficial outcomes and numerous adverse effects of widely used medications remain of chief concern, warranting in-depth studies. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439b37ba02fb53462db7f18de5b13d1d
https://doi.org/10.1016/j.neulet.2021.136194
https://doi.org/10.1016/j.neulet.2021.136194
Autor:
Štefan Nagy, Jana Gaburjakova, Martin Kopáni, Stefan Polak, Michal Sabo, Michal Trnka, Marta Gaburjakova, Daniel Kosnáč, Eva Krejciova, Helena Svobodová Kosnáčová
Publikováno v:
Archives of Biochemistry and Biophysics. 712:109031
Iron, an essential element for most living organism, participates in a wide variety of physiological processes. Disturbance in iron homeostasis has been associated with numerous pathologies, particularly in the heart and brain, which are the most sus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb09f04dd78903cbdcb6d018013f0b3
https://doi.org/10.1016/j.abb.2021.109031
https://doi.org/10.1016/j.abb.2021.109031
Publikováno v:
Bioelectrochemistry (Amsterdam, Netherlands). 132
Dysregulation of the cardiac ryanodine receptor (RYR2) by luminal Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d87db00525b589222e65c9616863c119
https://pubmed.ncbi.nlm.nih.gov/31918058
https://pubmed.ncbi.nlm.nih.gov/31918058
Autor:
Jana Gaburjakova, Marta Gaburjakova
Publikováno v:
Acta Physiologica. 219:757-767
Ca2+ plays a critical role in several processes involved in skeletal and cardiac muscle contraction. One key step in cardiac excitation-contraction (E-C) coupling is the activation of the cardiac ryanodine receptor (RYR2) by cytosolic Ca2+ elevations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97c661b1dad7d9954e5d6dd9f659fcb8
https://doi.org/10.1111/apha.12772
https://doi.org/10.1111/apha.12772
Autor:
Jana Gaburjakova, Marta Gaburjakova
Publikováno v:
Bioelectrochemistry. 109:49-56
A growing body of evidence suggests that the regulation of cardiac ryanodine receptor (RYR2) by luminal Ca(2+) is mediated by luminal binding sites located on the RYR2 channel itself and/or its auxiliary protein, calsequestrin. The localization and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d76468758980c76599e3b578c9d3b0
https://doi.org/10.1016/j.bioelechem.2016.01.002
https://doi.org/10.1016/j.bioelechem.2016.01.002
Autor:
Marta Gaburjakova, Jana Gaburjakova
Electrophysiological methods are the “gold standard” for ion channel research, providing valuable information about function and regulation even at the single-channel level. This is of critical importance in attempts to understand the molecular r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac500c48824a5f53dbec91e209dc1484
https://doi.org/10.1016/bs.abl.2017.12.005
https://doi.org/10.1016/bs.abl.2017.12.005
