Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Marta Gabasa"'
Autor:
Lourdes Chuliá-Peris, Cristina Carreres-Rey, Marta Gabasa, Jordi Alcaraz, Julián Carretero, Javier Pereda
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 6894 (2022)
Pulmonary fibrosis (PF) is characterized by aberrant extracellular matrix (ECM) deposition, activation of fibroblasts to myofibroblasts and parenchymal disorganization, which have an impact on the biomechanical traits of the lung. In this context, th
Externí odkaz:
https://doaj.org/article/8c320c10b8a040f2b9e1c8260be2b41d
Autor:
Marta Gabasa, Marselina Arshakyan, Alejandro Llorente, Lourdes Chuliá-Peris, Irina Pavelescu, Antoni Xaubet, Javier Pereda, Jordi Alcaraz
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8417 (2020)
Pro-inflammatory cytokines like interleukin-1β (IL-1β) are upregulated during early responses to tissue damage and are expected to transiently compromise the mechanical microenvironment. Fibroblasts are key regulators of tissue mechanics in the lun
Externí odkaz:
https://doaj.org/article/edcb3a73cc27447786d5685538d6c573
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 11, p 2431 (2017)
Idiopathic pulmonary fibrosis (IPF) is an aggressive disease in which normal lung parenchyma is replaced by a stiff dysfunctional scar rich in activated fibroblasts and collagen-I. We examined how the mechanochemical pro-fibrotic microenvironment pro
Externí odkaz:
https://doaj.org/article/cf376ac8baa44f6c82b23d2cf287582e
Autor:
Marta Gabasa, Dolores Royo, Maria Molina-Molina, Jordi Roca-Ferrer, Laura Pujols, Cesar Picado, Antoni Xaubet, Javier Pereda
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65445 (2013)
BACKGROUND: Prostaglandin E2 (PGE2), the main metabolite of cyclooxygenase (COX), is a well-known anti-fibrotic agent. Moreover, myofibroblasts expressing α-smooth muscle actin (α-SMA), fibroblast expansion and epithelial-mesenchymal transition (EM
Externí odkaz:
https://doaj.org/article/d872f9ec6950430cbe8fb7276b4ad92a
Autor:
Paula Duch, Natalia Díaz-Valdivia, Rafael Ikemori, Marta Gabasa, Evette S. Radisky, Marselina Arshakyan, Sabrina Gea-Sorlí, Anna Mateu-Bosch, Paloma Bragado, Josep Lluís Carrasco, Hidetoshi Mori, Josep Ramírez, Cristina Teixidó, Noemí Reguart, Cristina Fillat, Derek C. Radisky, Jordi Alcaraz
Publikováno v:
Matrix Biology. 111:207-225
Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an important regulator of extracellular matrix turnover that has been traditionally regarded as a potential tumor suppressor owing to its inhibitory effects of matrix metalloproteinases. Intriguingl
Autor:
Jordi Alcaraz, Noemí Reguart, Frank Hilberg, Cristina Fillat, Pere Gascon, Victor Ivo Peinado, Eduard Monsó, Manel Esteller, Luis M. Montuenga, Laura Soucek, Toni Jauset, Sabrina Gea-Sorli, Gemma Fuster, Manuel Castro, Sebastian Morán, Albert Marín, Iuliana-Cristiana Luis, Marselina Arshakyan, Paloma Bragado, Miguel Vizoso, Paula Duch, Marta Gabasa, Rafael Ikemori
Supplementary Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598a79d2e19d534941a510814593f277
https://doi.org/10.1158/0008-5472.22425144.v1
https://doi.org/10.1158/0008-5472.22425144.v1
Autor:
Jordi Alcaraz, Noemí Reguart, Frank Hilberg, Cristina Fillat, Pere Gascon, Victor Ivo Peinado, Eduard Monsó, Manel Esteller, Luis M. Montuenga, Laura Soucek, Toni Jauset, Sabrina Gea-Sorli, Gemma Fuster, Manuel Castro, Sebastian Morán, Albert Marín, Iuliana-Cristiana Luis, Marselina Arshakyan, Paloma Bragado, Miguel Vizoso, Paula Duch, Marta Gabasa, Rafael Ikemori
Supplementary Figures S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56afb2c2cae0c40addd1202a97a32f0e
https://doi.org/10.1158/0008-5472.22425150
https://doi.org/10.1158/0008-5472.22425150
Autor:
Jordi Alcaraz, Noemí Reguart, Frank Hilberg, Cristina Fillat, Pere Gascon, Victor Ivo Peinado, Eduard Monsó, Manel Esteller, Luis M. Montuenga, Laura Soucek, Toni Jauset, Sabrina Gea-Sorli, Gemma Fuster, Manuel Castro, Sebastian Morán, Albert Marín, Iuliana-Cristiana Luis, Marselina Arshakyan, Paloma Bragado, Miguel Vizoso, Paula Duch, Marta Gabasa, Rafael Ikemori
Supplementary Material
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eec7c27161817940df5c49135183c49
https://doi.org/10.1158/0008-5472.22425147
https://doi.org/10.1158/0008-5472.22425147
Autor:
Jordi Alcaraz, Noemí Reguart, Frank Hilberg, Cristina Fillat, Pere Gascon, Victor Ivo Peinado, Eduard Monsó, Manel Esteller, Luis M. Montuenga, Laura Soucek, Toni Jauset, Sabrina Gea-Sorli, Gemma Fuster, Manuel Castro, Sebastian Morán, Albert Marín, Iuliana-Cristiana Luis, Marselina Arshakyan, Paloma Bragado, Miguel Vizoso, Paula Duch, Marta Gabasa, Rafael Ikemori
The tumor-promoting fibrotic stroma rich in tumor-associated fibroblasts (TAF) is drawing increased therapeutic attention. Intriguingly, a trial with the antifibrotic drug nintedanib in non–small cell lung cancer reported clinical benefits in adeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7a12173d12743c4be33a01a3b0319fa
https://doi.org/10.1158/0008-5472.c.6511959.v1
https://doi.org/10.1158/0008-5472.c.6511959.v1
Autor:
Paula Duch, Natalia Díaz-Valdivia, Marta Gabasa, Rafael Ikemori, Frank Hilberg, Noemí Reguart, Derek Radisky, Jordi Alcaraz
Publikováno v:
Cancer Research. 83:2356-2356
Adenocarcinoma (ADC) and Squamous Cell Carcinoma (SCC) are the most frequent histologic subtypes of lung cancer, and both are rich in activated/myofibroblast-like tumor-associated fibroblasts (TAFs). Nintedanib is a potent antifibrotic drug that targ