Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Marta E Fabregat"'
Autor:
M. Barbacid, Conchi Mora, Carmen Franco, Javier Martín, E F Usac, Nuria Marzo, Marta E Fabregat, Roger R. Gomis
Publikováno v:
Diabetologia. 47:686-694
Cyclin-dependent kinase 4 (Cdk4) is crucial for beta cell development. A mutation in the gene encoding for Cdk4, Cdk4R24C, causes this kinase to be insensitive to INK4 cell cycle inhibitors and induces beta cell hyperplasia in Cdk4R24C knockin mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89511a3d65131c5fa48c708c5f8a9d94
https://doi.org/10.1007/s00125-004-1372-0
https://doi.org/10.1007/s00125-004-1372-0
Autor:
Ramon Gomis, Willy Malaisse, Joanne Rasschaert, Monica Gudayol, Marta E Fabregat, Abdullah Sener
Publikováno v:
Molecular Genetics and Metabolism. 75:168-173
Single-strand conformational polymorphism analysis of mitochondrial FAD-linked glycerophosphate dehydrogenase (mGDH) gene has revealed mutations in both the calcium- and FAD-binding domains of this enzyme in some diabetic patients. It was now investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7734f561a9d501ecc02d3160f7fae48c
https://doi.org/10.1006/mgme.2001.3286
https://doi.org/10.1006/mgme.2001.3286
Autor:
Monica Gudayol, Albert Morales, E F Usac, José C. Fernández-Checa, Ramon Gomis, Josep Vidal, Marta E Fabregat, Anna Novials
Publikováno v:
Endocrine. 16:39-42
Ca2+-responsive mitochondrial FAD-linked glycerophosphate dehydrogenase (mGPDH) is a key component of the pancreatic beta-cell glucose-sensing device. The purpose of this study was to examine the association of mutations in the cDNA coding for the FA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::853339e3183328f1a77c9b06c19464fa
https://doi.org/10.1385/endo:16:1:39
https://doi.org/10.1385/endo:16:1:39
Publikováno v:
Biochemical and Biophysical Research Communications. 268:491-495
Previous reports concerning the regulation of glucokinase expression in beta cells have been done using cell models from rodent origin. Evidence is lacking so far to implicate the same regulatory mechanisms in human cells. In this study, we investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5607b6fadf50e822b96ad59775289b8d
https://doi.org/10.1006/bbrc.2000.2150
https://doi.org/10.1006/bbrc.2000.2150
Autor:
Josep Vidal, Marta E Fabregat, Monica Gudayol, Carmen Zamorano Benito, Teresa Gallart, Willy Malaisse, Ramon Gomis
Publikováno v:
Biochemical and Molecular Medicine. 62:172-177
The mitochondrial enzyme FAD-linked glycerophosphate dehydrogenase (mGDH) plays a key role in the recognition of glucose as a stimulus for insulin release from the pancreatic islet B-cell. In the present study, an ELISA procedure was used for the mea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413a443105ef743cb2938f779483a486
https://doi.org/10.1006/bmme.1997.2642
https://doi.org/10.1006/bmme.1997.2642
Autor:
Marie-Hélène Giroix, Anna Novials, Abdullah Sener, Marta E Fabregat, Willy Malaisse, Ramon Gomis
Publikováno v:
Biochemical and Biophysical Research Communications. 220:1020-1023
Western blotting of pancreatic islet extracts from either hereditarily diabetic Goto-Kakizaki rats (GK rats) or animals injected with streptozotocin during the neonatal period (STZ rats) demonstrated a pronounced decrease of immunoreactive mitochondr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d2ae85fa9731b39d679ed5aab42a15
https://doi.org/10.1006/bbrc.1996.0525
https://doi.org/10.1006/bbrc.1996.0525
Publikováno v:
Diabetes. 51(4)
Plasma insulin in healthy subjects shows regular oscillations, which are important for the hypoglycemic action of the hormone. In individuals with type 2 diabetes, these regular variations are altered, which has been implicated in the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f9ea8317b62973205f9e8e00c24ef5
https://pubmed.ncbi.nlm.nih.gov/11916916
https://pubmed.ncbi.nlm.nih.gov/11916916
Autor:
Josefa Fernandez-Álvarez, Michela Novelli, Ramon Gomis, Marta E Fabregat, Pellegrino Masiello
In a new experimental type 2 diabetic syndrome, a 40% reduction of pancreatic beta cells was observed by morphometric analysis. In diabetic islets, as compared to control islets, insulin release was decreased in response to high glucose but not to ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905888bf059d55eaa550934f7e0ccd2e
http://hdl.handle.net/11568/177211
http://hdl.handle.net/11568/177211
Autor:
Camino Rodriguez, Rosa Gasa, Ramon Gomis, Willy Malaisse, Anna Novials, Marta E Fabregat, Teresa Gallart
Publikováno v:
Diabetes research and clinical practice. 38(2)
The mitochondrial enzyme FAD-linked glycerophosphate dehydrogenase (mGDH) plays a key role in the recognition of D-glucose as a stimulus for insulin release from the pancreatic islet B-cell. This study reveals that autoantibodies against this enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ea445a87c6afe91505c5adbc0e3cca
https://pubmed.ncbi.nlm.nih.gov/9483375
https://pubmed.ncbi.nlm.nih.gov/9483375
Autor:
Josefa Fernandez-Álvarez, Carmen Zamorano Benito, Willy Malaisse, Marta E Fabregat, Anna Novials, Teresa Gallart, Ramon Gomis
Publikováno v:
Biochemical and molecular medicine. 59(2)
The mitochondrial enzyme glycerophosphate dehydrogenase (mGDH) plays an essential role in the B-cell glucose-sensing device and its activity in islet homogenates is impaired in several animal models of type 2 diabetes. We have now developed a polyclo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e3fafdd86e16916b0b99654d517f0d
https://pubmed.ncbi.nlm.nih.gov/8986643
https://pubmed.ncbi.nlm.nih.gov/8986643