Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Marta E Fabregat"'
Autor:
M. Barbacid, Conchi Mora, Carmen Franco, Javier Martín, E F Usac, Nuria Marzo, Marta E Fabregat, Roger R. Gomis
Publikováno v:
Diabetologia. 47:686-694
Cyclin-dependent kinase 4 (Cdk4) is crucial for beta cell development. A mutation in the gene encoding for Cdk4, Cdk4R24C, causes this kinase to be insensitive to INK4 cell cycle inhibitors and induces beta cell hyperplasia in Cdk4R24C knockin mice.
Autor:
Ramon Gomis, Willy Malaisse, Joanne Rasschaert, Monica Gudayol, Marta E Fabregat, Abdullah Sener
Publikováno v:
Molecular Genetics and Metabolism. 75:168-173
Single-strand conformational polymorphism analysis of mitochondrial FAD-linked glycerophosphate dehydrogenase (mGDH) gene has revealed mutations in both the calcium- and FAD-binding domains of this enzyme in some diabetic patients. It was now investi
Autor:
Monica Gudayol, Albert Morales, E F Usac, José C. Fernández-Checa, Ramon Gomis, Josep Vidal, Marta E Fabregat, Anna Novials
Publikováno v:
Endocrine. 16:39-42
Ca2+-responsive mitochondrial FAD-linked glycerophosphate dehydrogenase (mGPDH) is a key component of the pancreatic beta-cell glucose-sensing device. The purpose of this study was to examine the association of mutations in the cDNA coding for the FA
Publikováno v:
Biochemical and Biophysical Research Communications. 268:491-495
Previous reports concerning the regulation of glucokinase expression in beta cells have been done using cell models from rodent origin. Evidence is lacking so far to implicate the same regulatory mechanisms in human cells. In this study, we investiga
Autor:
Josep Vidal, Marta E Fabregat, Monica Gudayol, Carmen Zamorano Benito, Teresa Gallart, Willy Malaisse, Ramon Gomis
Publikováno v:
Biochemical and Molecular Medicine. 62:172-177
The mitochondrial enzyme FAD-linked glycerophosphate dehydrogenase (mGDH) plays a key role in the recognition of glucose as a stimulus for insulin release from the pancreatic islet B-cell. In the present study, an ELISA procedure was used for the mea
Autor:
Marie-Hélène Giroix, Anna Novials, Abdullah Sener, Marta E Fabregat, Willy Malaisse, Ramon Gomis
Publikováno v:
Biochemical and Biophysical Research Communications. 220:1020-1023
Western blotting of pancreatic islet extracts from either hereditarily diabetic Goto-Kakizaki rats (GK rats) or animals injected with streptozotocin during the neonatal period (STZ rats) demonstrated a pronounced decrease of immunoreactive mitochondr
Publikováno v:
Diabetes. 51(4)
Plasma insulin in healthy subjects shows regular oscillations, which are important for the hypoglycemic action of the hormone. In individuals with type 2 diabetes, these regular variations are altered, which has been implicated in the development of
Autor:
Josefa Fernandez-Álvarez, Michela Novelli, Ramon Gomis, Marta E Fabregat, Pellegrino Masiello
In a new experimental type 2 diabetic syndrome, a 40% reduction of pancreatic beta cells was observed by morphometric analysis. In diabetic islets, as compared to control islets, insulin release was decreased in response to high glucose but not to ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905888bf059d55eaa550934f7e0ccd2e
http://hdl.handle.net/11568/177211
http://hdl.handle.net/11568/177211
Autor:
Camino Rodriguez, Rosa Gasa, Ramon Gomis, Willy Malaisse, Anna Novials, Marta E Fabregat, Teresa Gallart
Publikováno v:
Diabetes research and clinical practice. 38(2)
The mitochondrial enzyme FAD-linked glycerophosphate dehydrogenase (mGDH) plays a key role in the recognition of D-glucose as a stimulus for insulin release from the pancreatic islet B-cell. This study reveals that autoantibodies against this enzyme
Autor:
Josefa Fernandez-Álvarez, Carmen Zamorano Benito, Willy Malaisse, Marta E Fabregat, Anna Novials, Teresa Gallart, Ramon Gomis
Publikováno v:
Biochemical and molecular medicine. 59(2)
The mitochondrial enzyme glycerophosphate dehydrogenase (mGDH) plays an essential role in the B-cell glucose-sensing device and its activity in islet homogenates is impaired in several animal models of type 2 diabetes. We have now developed a polyclo