Efferocytosis requires periphagosomal Ca2+-signaling and TRPM7-mediated electrical activity

Autor: Michael S. Schappe, Marta E. Stremska, Gregory W. Busey, Taylor K. Downs, Philip V. Seegren, Suresh K. Mendu, Zachary Flegal, Catherine A. Doyle, Eric J. Stipes, Bimal N. Desai

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Efficient removal of apoptotic cells by phagocytosis underlies tissue development, wound repair, host defense and organ homeostasis. Here, authors identify TRPM7 as a regulator of cargo acidification and Ca2+ signaling during apoptotic cell clearance

Externí odkaz: https://doaj.org/article/91b4d7f5e2564ec69283f69be2f00ae0

IL233, an IL-2-IL-33 hybrid cytokine induces prolonged remission of mouse lupus nephritis by targeting Treg cells as a single therapeutic agent

Autor: Marta E. Stremska, Vikram Sabapathy, Sheethal Jose, Rahul Sharma, Chao Dai, Sun-Sang J. Sung, Shu Man Fu, Gaurav Kumar, Hongyang Wang, Rajkumar Venkatadri, Saleh Mohammad

Publikováno v: J Autoimmun

Lupus glomerulonephritis (GN) is an autoimmune disease characterized by immune complex-deposition, complement activation and glomerular inflammation. In lupus-prone NZM2328 mice, the occurrence of lupus GN was accompanied by a decrease in Treg cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c399c550fc764844c5bde59f6fd0e09
https://doi.org/10.1016/j.jaut.2019.05.005

Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation

Autor: Christopher B. Medina, Ivan K. H. Poon, Yu-Hsin Chiu, Ulrike Lorenz, Kenneth S. K. Tung, Marta E. Stremska, Kodi S. Ravichandran, Christopher D. Lucas, Douglas A. Bayliss, Bimal N. Desai, Michael R. Elliott

Publikováno v: Medina, C B, Chiu, Y-H, Stremska, M E, Lucas, C D, Poon, I, Tung, K S, Elliott, M R, Desai, B, Bayliss, D A, Lorenz, U M & Ravichandran, K S 2021, ' Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation ', Immunity . https://doi.org/10.1016/j.immuni.2021.06.014
IMMUNITY
Immunity

Allergic airway inflammation affects millions of people world-wide. Among the many factors affecting airway inflammation, type 2 inflammatory responses coordinated by CD4+ T cells are important in disease progression. Pannexins are plasma membrane ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e193cf3e1a4d915f8b86ee6a97b19e
https://doi.org/10.1016/j.immuni.2021.06.014

Novel Immunomodulatory Cytokine Regulates Inflammation, Diabetes, and Obesity to Protect From Diabetic Nephropathy

Autor: Poonam Sharma, Vikram Sabapathy, Rebecca L. Corey, Saleh Mohammad, Rahul Sharma, Marta E. Stremska

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)
Frontiers in Pharmacology

Obesity-linked (type 2) diabetic nephropathy (T2DN) has become the largest contributor to morbidity and mortality in the modern world. Recent evidences suggest that inflammation may contribute to the pathogenesis of T2DN and T-regulatory cells (Treg)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e039190591682133be95f6b1acf61332

Chanzyme TRPM7 Mediates the Ca

Autor: Michael S, Schappe, Kalina, Szteyn, Marta E, Stremska, Suresh K, Mendu, Taylor K, Downs, Philip V, Seegren, Michelle A, Mahoney, Sumeet, Dixit, Julia K, Krupa, Eric J, Stipes, Jason S, Rogers, Samantha E, Adamson, Norbert, Leitinger, Bimal N, Desai

Publikováno v: Immunity. 48(1)

Toll-like receptors (TLRs) sense pathogen-associated molecular patterns to activate the production of inflammatory mediators. TLR4 recognizes lipopolysaccharide (LPS) and drives the secretion of inflammatory cytokines, often contributing to sepsis. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f2f62d7f5bbddeafebef5fef9e00da1
https://pubmed.ncbi.nlm.nih.gov/29343439