Výsledky vyhledávání - "Marta De Menna"

Akademický článek

Guidance of adjuvant instillation in intermediate-risk non-muscle invasive bladder cancer by drug screens in patient derived organoids: a single center, open-label, phase II trial

Autor: Roland Seiler, Martin Egger, Marta De Menna, Saskia Wehrli, Martina Minoli, Martina Radić, Pavel Lyatoshinsky, Raphael Hösli, Jennifer Blarer, Dominik Abt, Marianna Kruithof-de Julio

Publikováno v: BMC Urology, Vol 23, Iss 1, Pp 1-7 (2023)

Abstract Background In intermediate-risk non-muscle invasive bladder cancer (NMIBC) clinical guidelines suggest an adjuvant instillation with a chemotherapeutic agent. However, the agent and regimen are not clearly defined. Worldwide, less than 15% o

Externí odkaz: https://doaj.org/article/58a2d04374764b54b6fc5a2070a7d305

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Akademický článek

A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection

Autor: Pasquale Laise, Megan L. Stanifer, Gideon Bosker, Xiaoyun Sun, Sergio Triana, Patricio Doldan, Federico La Manna, Marta De Menna, Ronald B. Realubit, Sergey Pampou, Charles Karan, Theodore Alexandrov, Marianna Kruithof-de Julio, Andrea Califano, Steeve Boulant, Mariano J. Alvarez

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)

Master Regulator proteins, controlling the transcriptional identity of infected cells, can serve as drug targets for inhibiting virus replication, here demonstrated in a SARSCoV-2 infection model.

Externí odkaz: https://doaj.org/article/2848e83b0ed146a0b6c215d5176e0325

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Akademický článek

GATA3 and MDM2 are synthetic lethal in estrogen receptor-positive breast cancers

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)

GATA3 mutations are common in ER-positive breast cancers yet are not targetable. This study describes pharmacological inhibition of MDM2 as a novel approach to target GATA3 deficiency, providing a molecularly guided treatment for this patient subclas

Externí odkaz: https://doaj.org/article/9071cb3253ff484fad39debd9d0d2d7d

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Akademický článek

Patient-derived xenografts and organoids model therapy response in prostate cancer

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

To date, patients still succumb to cancer, due to tumors not responding to therapy or ultimately acquiring resistance. Here the authors show that by exploiting patient derived organoids and a treatment-naïve patient derived xenograft, patient therap

Externí odkaz: https://doaj.org/article/74f8126482f64e7aa57d9156cdf767c0

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Akademický článek

Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label therapy

Publikováno v: Cell Genomics, Vol 2, Iss 2, Pp 100095- (2022)

Summary: Pancreatic cancer (PDAC) is a highly aggressive malignancy for which the identification of novel therapies is urgently needed. Here, we establish a human PDAC organoid biobank from 31 genetically distinct lines, covering a representative ran

Externí odkaz: https://doaj.org/article/528029a5e0b440e9b617944420259540

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Akademický článek

Dual-mTOR Inhibitor Rapalink-1 Reduces Prostate Cancer Patient-Derived Xenograft Growth and Alters Tumor Heterogeneity

Autor: Federico La Manna, Marta De Menna, Nikhil Patel, Sofia Karkampouna, Maria De Filippo, Irena Klima, Peter Kloen, Lijkele Beimers, George N. Thalmann, Rob C. M. Pelger, Estela Jacinto, Marianna Kruithof-de Julio

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Bone metastasis is the leading cause of prostate cancer (PCa) mortality, frequently marking the progression to castration-resistant PCa. Dysregulation of the androgen receptor pathway is a common feature of castration-resistant PCa, frequently appear

Externí odkaz: https://doaj.org/article/914236bb387547269f378db2b2a702de

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Akademický článek

FOXE1-Dependent Regulation of Macrophage Chemotaxis by Thyroid Cells In Vitro and In Vivo

Autor: Sara C. Credendino, Marta De Menna, Irene Cantone, Carmen Moccia, Matteo Esposito, Luigi Di Guida, Mario De Felice, Gabriella De Vita

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 14, p 7666 (2021)

Forkhead box E1 (FOXE1) is a lineage-restricted transcription factor involved in thyroid cancer susceptibility. Cancer-associated polymorphisms map in regulatory regions, thus affecting the extent of gene expression. We have recently shown that genet

Externí odkaz: https://doaj.org/article/cc0850c4868d4361bcf67e88962468b6

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