pH-Responsive Self-Assembly of Amyloid Fibrils for Dual Hydrolase-Oxidase Reactions

Autor: Susanna Navarro, Salvador Ventura, Francesc Teixidor, Francesca Peccati, Marta Díaz-Caballero, Miquel Nuez-Martínez, Mariona Sodupe, Luis Rodríguez-Santiago

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)

There is an increasing interest in synthetic systems that can execute bioinspired chemical reactions without requiring the complex structures that characterize enzymes in their components. The hierarchical self-assembly of peptides provides a means t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152f43e4716c89547aadcd69c61a1552
http://hdl.handle.net/10261/239692

Soluble Assemblies in the Fibrillation Pathway of Prion-Inspired Artificial Functional Amyloids are Highly Cytotoxic

Autor: Salvador Ventura, Susanna Navarro, Marta Díaz-Caballero

Publikováno v: Biomacromolecules. 21(6)

Amyloids are associated with human disease. However, they are also exploited by nature for functional purposes. Functional amyloids have inspired amyloid-based biomaterials for different nanotechnologies. Early soluble species in the fibrillation pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1faeb0aa3b9e8ec1982b5e8005d9b4b7
https://pubmed.ncbi.nlm.nih.gov/32227922

Combining Structural Aggregation Propensity and Stability Predictions To Redesign Protein Solubility

Autor: Marcos Gil-Garcia, Salvador Ventura, Michał H. Jamróz, Nathalia Varejão, Sebastian Kmiecik, Manuel Bañó-Polo, Aleksander Kuriata, David Reverter, Marta Díaz-Caballero, Jara Lascorz, Bertrand Morel, Susanna Navarro

Publikováno v: Molecular Pharmaceutics. 15:3846-3859

The aggregation propensity of each particular protein seems to be shaped by evolution according to its natural abundance in the cell. The production and downstream processing of recombinant polypeptides implies attaining concentrations that are order

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a833ba5fdf751309738fc96b600c763
https://doi.org/10.1021/acs.molpharmaceut.8b00341

The prion-like RNA-processing protein HNRPDL forms inherently toxic amyloid-like inclusion bodies in bacteria

Autor: Patrizia Marinelli, Susanna Navarro, Marta Díaz-Caballero, Salvador Ventura

Publikováno v: Microbial Cell Factories
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

Background The formation of protein inclusions is connected to the onset of many human diseases. Human RNA binding proteins containing intrinsically disordered regions with an amino acid composition resembling those of yeast prion domains, like TDP-4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4dca533f6d4af800506a52f87cdbaf
https://doi.org/10.1186/s12934-015-0284-7