Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Marta Clemente-Ruiz"'
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 119-131.e4 (2019)
Summary: Several oncogenes induce untimely entry into S phase and alter replication timing and progression, thereby generating replicative stress, a well-known source of genomic instability and a hallmark of cancer. Using an epithelial model in Droso
Externí odkaz:
https://doaj.org/article/576a49b26f6c4497bbf6adcf96fa7a9c
Publikováno v:
PLoS Genetics, Vol 7, Iss 11, p e1002376 (2011)
Chromatin assembly mutants accumulate recombinogenic DNA damage and are sensitive to genotoxic agents. Here we have analyzed why impairment of the H3K56 acetylation-dependent CAF1 and Rtt106 chromatin assembly pathways, which have redundant roles in
Externí odkaz:
https://doaj.org/article/5f9c93e86cae47989062b4c0749827ed
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12143 (2010)
The SWR1 complex replaces the canonical histone H2A with the variant H2A.Z (Htz1 in yeast) at specific chromatin regions. This dynamic alteration in nucleosome structure provides a molecular mechanism to regulate transcription, gene silencing, chromo
Externí odkaz:
https://doaj.org/article/1e892aa494e5483c8c05bd2def38ed85
Autor:
Nikolaos Nikiforos Giakoumakis, Marco Milán, Jery Joy, Daniela Romão, Celia Santos-Tapia, Lara Barrio, Marta Clemente-Ruiz
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
Aneuploidy, an unbalanced number of chromosomes, is highly deleterious at the cellular level and leads to senescence, a stress-induced response characterized by permanent cell-cycle arrest and a well-defined associated secretory phenotype. Here, we u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d42137a71648bb51d9882853f2ae18
https://doi.org/10.1016/j.devcel.2021.06.009
https://doi.org/10.1016/j.devcel.2021.06.009
Autor:
Marta Barrientos-Moreno, Félix Prado, Macarena Morillo-Huesca, Marta Clemente-Ruiz, Marina Murillo-Pineda, Elena Gómez-Marín
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Genetics
instname
Genetics
The accuracy of most DNA processes depends on chromatin integrity and dynamics. Our analyses in the yeast Saccharomyces cerevisiae show that an absence of Swr1 (the catalytic and scaffold subunit of the chromatin-remodeling complex SWR) leads to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2401eed9ade5db2cc1bb3488be49ead0
http://hdl.handle.net/10261/205555
http://hdl.handle.net/10261/205555
Autor:
Marta Clemente-Ruiz, Lidia Pérez, Juan Manuel Murillo-Maldonado, Lara Barrio, Gonzalo Quiroga, Najate Benhra, Marco Milán, Angel R. Nebreda
Publikováno v:
Developmental Cell. 36(3):290-302
SummaryChromosomal instability (CIN) is thought to be a source of mutability in cancer. However, CIN often results in aneuploidy, which compromises cell fitness. Here, we used the dosage compensation mechanism (DCM) of Drosophila to demonstrate that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0056498d788d268e470cbc76d11c6aa
Autor:
Félix Prado, Marta Clemente-Ruiz
Publikováno v:
BioArchitecture. 2:6-10
Maintaining the stability of the replication forks is one of the main tasks of the DNA damage response. Specifically, checkpoint mechanisms detect stressed forks and prevent their collapse. In the published report reviewed here we have shown that def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aab7b24c91de06b373e8c6a85b8a682
https://doi.org/10.4161/bioa.19737
https://doi.org/10.4161/bioa.19737
Publikováno v:
Seminars in celldevelopmental biology. 28
Aneuploidy, described as an abnormal number of whole chromosomes or parts of them, has been observed in the majority of sporadic carcinomas, the most common type of cancer occurring in humans and derived from putative epithelial cells. However, the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5bc6c0ad4749807e7d9a17a054a2af
https://pubmed.ncbi.nlm.nih.gov/24641887
https://pubmed.ncbi.nlm.nih.gov/24641887
Autor:
Félix Prado, Fernando Monje-Casas, Marina Murillo-Pineda, Marta Clemente-Ruiz, María J. Cabello-Lobato
Publikováno v:
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
Nucleic Acids Research
instname
Digital.CSIC. Repositorio Institucional del CSIC
Nucleic Acids Research
The structural organization of chromosomes is essential for their correct function and dynamics during the cell cycle. The assembly of DNA into chromatin provides the substrate for topoisomerases and condensins, which introduce the different levels o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca1b6254b0edfc393f1cf35a5f1a573
https://idus.us.es/handle/11441/64160
https://idus.us.es/handle/11441/64160
Autor:
Marta Clemente-Ruiz, Félix Prado
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
7 pages, 5 figures
During DNA replication, the advance of replication forks is tightly connected with chromatin assembly, a process that can be impaired by the partial depletion of histone H4 leading to recombinogenic DNA damage. Here, we show t
During DNA replication, the advance of replication forks is tightly connected with chromatin assembly, a process that can be impaired by the partial depletion of histone H4 leading to recombinogenic DNA damage. Here, we show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1837ea9b53fe80be43bfb5c90064ca2
https://europepmc.org/articles/PMC2727422/
https://europepmc.org/articles/PMC2727422/