Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Marta C. Abad"'
Autor:
Fiona Madden, Kevin Clark, Marta C. Abad, Jingjie Mo, Caitlin O'Mahony Hartnett, Nikky Le, Barry McCarthy, Jim O'Mahony, Luke A. Gibbons, Francis Maslanka, Christopher Rode, Rosemary Rea, Kerry Robinson, Carl Rafferty, Ronan Hayes
Publikováno v:
Biotechnology Progress. 38
The Quality by Design (QbD) approach to the production of therapeutic monoclonal antibodies (mAbs) emphasizes an understanding of the production process ensuring product quality is maintained throughout. Current methods for measuring Critical Quality
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92464d4f2121ab1b0ba1fc9936763aed
https://doi.org/10.1002/btpr.3223
https://doi.org/10.1002/btpr.3223
Autor:
Lawrence C. Kuo, Gee-Hong Kuo, Weimei Sun, Fengbing Song, Zhihua Sui, Amy Xiang, Alan C. Gibbs, Marta C. Abad, Xuqing Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4762-4767
A series of indazoles have been discovered as KHK inhibitors from a pyrazole hit identified through fragment-based drug discovery (FBDD). The optimization process guided by both X-ray crystallography and solution activity resulted in lead-like compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3563e5684ecac436575d2088b57b67
https://doi.org/10.1016/j.bmcl.2011.06.067
https://doi.org/10.1016/j.bmcl.2011.06.067
Autor:
Kiev S. Ly, John M. Keith, Carsten Schubert, Jiejun Wu, Michael A. Letavic, Ann J. Barbier, Sandy J. Wilson, Marta C. Abad, Brian Lord, Heather McAllister, Kirsten L. Miller, Nicholas I. Carruthers, Emily M. Stocking, D.J. Tognarelli, Jill A. Jablonowski, Timothy W. Lovenberg, Leslie A. Gomez, Pascal Bonaventure, Jamin D. Boggs, Jennifer M. Miller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1047-1051
A series of novel 4-aryl-1,2,3,4-tetrahydroisoquinoline-based histamine H(3) ligands that also have serotonin reuptake transporter inhibitor activity is described. The synthesis, in vitro biological data, and select pharmacokinetic data for these nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18387593a9ce978641ff4e2bca48f8a
https://doi.org/10.1016/j.bmcl.2006.11.036
https://doi.org/10.1016/j.bmcl.2006.11.036
Autor:
Francis J. Castellino, James H. Geiger, Raghuvir K. Arni, Marta C. Abad, Davida K. Grella, Alexander Tulinsky
Publikováno v:
Journal of Molecular Biology. 318:1009-1017
Angiogenesis inhibitors have gained much public attention recently as anti-cancer agents and several are currently in clinical trials, including angiostatin (Phase I, Thomas Jefferson University Hospital, Philadelphia, PA). We report here the bowl-sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa018126762529840344688034931ca
https://doi.org/10.1016/s0022-2836(02)00211-5
https://doi.org/10.1016/s0022-2836(02)00211-5
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 58:359-361
Branching enzyme catalyzes the formation of the branch points in glycogen and starch by cleavage of the alpha-1,4 link and its subsequent transfer to the alpha-1,6 position. This paper reports the crystallization and preliminary structural studies of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4be04d101139fa6e291a52b408696e
https://doi.org/10.1107/s090744490102073x
https://doi.org/10.1107/s090744490102073x
Autor:
Alan C. Gibbs, John A. Masucci, Bruce E. Maryanoff, Diane K. Luci, Marta C. Abad, Ioanna Petrounia, David F. McComsey, William J. Jones, John O’Neill, Stephen C. Yabut, Alfonzo D. Jordan
Publikováno v:
ACS medicinal chemistry letters. 2(7)
Attenuation of fructose metabolism by the inhibition of ketohexokinase (KHK; fructokinase) should reduce body weight, free fatty acids, and triglycerides, thereby offering a novel approach to treat diabetes and obesity in response to modern diets. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810e5f66c59c7587d643c2f9868e0331
https://pubmed.ncbi.nlm.nih.gov/24900346
https://pubmed.ncbi.nlm.nih.gov/24900346
Publikováno v:
Methods in enzymology. 493
We describe here a method using protein crystallography as the sole detection tool for fragment-based lead discovery. The methodology consists of iterative design, synthesis, and X-ray crystallographic screening of three libraries of compounds. Targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ab2c3f86486819039590b55f1e2a45d
https://pubmed.ncbi.nlm.nih.gov/21371603
https://pubmed.ncbi.nlm.nih.gov/21371603
Autor:
John G. Geisler, Lily Lee Searle, Hossein Askari, Debyendu De, John O’Neill, Michael Kemmerer, James M Lenhard, Jianying Liu, Ling Lin, Xizhen Zhu, Marta C. Abad, Jyotsna Kasturi, Micheal Gaul, Raymond J. Patch, Dionisios Rentzeperis, Mark R. Player, Alexander Kim
Publikováno v:
Journal of medicinal chemistry. 54(3)
Estrogen-related receptor α (ERRα) is an orphan nuclear receptor that has been functionally implicated in the regulation of energy homeostasis. Herein is described the development of diaryl ether based thiazolidenediones, which function as selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b60672295f1eee8d6b63f3dd787717b
https://pubmed.ncbi.nlm.nih.gov/21218783
https://pubmed.ncbi.nlm.nih.gov/21218783
Autor:
Zhihua Sui, Marta C. Abad, Francis A. Lewandowski, Xuqing Zhang, Geoffrey T. Struble, Weimei Sun, Alan C. Gibbs, Lawrence C. Kuo, Brett A. Tounge
Publikováno v:
Journal of medicinal chemistry. 53(22)
A fragment-based drug design paradigm has been successfully applied in the discovery of lead series of ketohexokinase inhibitors. The paradigm consists of three iterations of design, synthesis, and X-ray crystallographic screening to progress low mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0993e55c6f436620bd50441f0023f41d
https://pubmed.ncbi.nlm.nih.gov/21033679
https://pubmed.ncbi.nlm.nih.gov/21033679
Autor:
Shariff Bayoumy, Bruce E. Maryanoff, Lawrence de Garavilla, Jukka Kervinen, Marta C. Abad, Carl Crysler, Michael N. Greco, Ingrid Deckman, John C. Spurlino
Publikováno v:
Biochemical pharmacology. 80(7)
Chymases (EC 3.4.21.39) are mast cell serine proteinases that are variably expressed in different species and, in most cases, display either chymotryptic or elastolytic substrate specificity. Given that chymase inhibitors have emerged as potential th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea39370ce6ec61b7e6d5fae0cdbdb4a
https://pubmed.ncbi.nlm.nih.gov/20599788
https://pubmed.ncbi.nlm.nih.gov/20599788