Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Marta Bosch-Marce"'
Autor:
Raul Vizcardo, Nicholas D. Klemen, S.M. Rafiqul Islam, Devikala Gurusamy, Naritaka Tamaoki, Daisuke Yamada, Haruhiko Koseki, Benjamin L. Kidder, Zhiya Yu, Li Jia, Amanda N. Henning, Meghan L. Good, Marta Bosch-Marce, Takuya Maeda, Chengyu Liu, Zied Abdullaev, Svetlana Pack, Douglas C. Palmer, David F. Stroncek, Fumito Ito, Francis A. Flomerfelt, Michael J. Kruhlak, Nicholas P. Restifo
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3175-3190 (2018)
Summary: Induced pluripotent stem cell (iPSC)-derived T cells may provide future therapies for cancer patients, but those generated by current methods, such as the OP9/DLL1 system, have shown abnormalities that pose major barriers for clinical transl
Externí odkaz:
https://doaj.org/article/720cb2131104496bbbc49192af4af5f1
Autor:
S.M. Rafiqul Islam, Takuya Maeda, Naritaka Tamaoki, Meghan L. Good, Rigel J. Kishton, Biman C. Paria, Zhiya Yu, Marta Bosch-Marce, Nicole M. Bedanova, Chengyu Liu, Michael J. Kruhlak, Nicholas P. Restifo, Raul Vizcardo
Publikováno v:
Cancer Research Communications. 3:917-932
Tumor-infiltrating lymphocytes (TIL) that can recognize and kill tumor cells have curative potential in subsets of patients treated with adoptive cell transfer (ACT). However, lack of TIL therapeutic efficacy in many patients may be due in large part
Autor:
Raul Vizcardo, Nicholas P. Restifo, Michael J. Kruhlak, Chengyu Liu, Nicole M. Bedanova, Marta Bosch-Marce, Zhiya Yu, Biman C. Paria, Rigel J. Kishton, Meghan L. Good, Naritaka Tamaoki, Takuya Maeda, S.M. Rafiqul Islam
The list of antibodies used in the study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9675074aa2457f197b048919763451
https://doi.org/10.1158/2767-9764.23185862.v1
https://doi.org/10.1158/2767-9764.23185862.v1
Autor:
Raul Vizcardo, Nicholas P. Restifo, Michael J. Kruhlak, Chengyu Liu, Nicole M. Bedanova, Marta Bosch-Marce, Zhiya Yu, Biman C. Paria, Rigel J. Kishton, Meghan L. Good, Naritaka Tamaoki, Takuya Maeda, S.M. Rafiqul Islam
TIL-tumor cell coculture activated tumor-reactive T cells and generated tumor-reactive TIL-iPSCs from TIL of patient 3784. A, FACS panels showing the gating strategy to sort PD1+ 4-1BB+ CD8+ T cells after TIL-tumor cell coculture. Top panel shows the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16669b48faf82ab76a9ce08323434de4
https://doi.org/10.1158/2767-9764.23185892.v1
https://doi.org/10.1158/2767-9764.23185892.v1
Autor:
Raul Vizcardo, Nicholas P. Restifo, Michael J. Kruhlak, Chengyu Liu, Nicole M. Bedanova, Marta Bosch-Marce, Zhiya Yu, Biman C. Paria, Rigel J. Kishton, Meghan L. Good, Naritaka Tamaoki, Takuya Maeda, S.M. Rafiqul Islam
TCR stimulation is necessary for T cells to be reprogrammed to T-iPSCs. A, Schematic representation of PBMC derived T-cell reprogramming into iPSC. Whole PB T cells or the sorted populations were stimulated by αCD3/28 beads, and transduced with Send
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cccdc832c23658bbd2eb4220fabec03
https://doi.org/10.1158/2767-9764.23185910
https://doi.org/10.1158/2767-9764.23185910
Autor:
Raul Vizcardo, Nicholas P. Restifo, Michael J. Kruhlak, Chengyu Liu, Nicole M. Bedanova, Marta Bosch-Marce, Zhiya Yu, Biman C. Paria, Rigel J. Kishton, Meghan L. Good, Naritaka Tamaoki, Takuya Maeda, S.M. Rafiqul Islam
Table S1 indicating TIL-iPSCs were established from T cells of low frequency along with major tumor neoantigen specific T cells from patient 3784
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d08e12803671250c65ef1328ef5256
https://doi.org/10.1158/2767-9764.23185859.v1
https://doi.org/10.1158/2767-9764.23185859.v1
Autor:
Raul Vizcardo, Nicholas P. Restifo, Michael J. Kruhlak, Chengyu Liu, Nicole M. Bedanova, Marta Bosch-Marce, Zhiya Yu, Biman C. Paria, Rigel J. Kishton, Meghan L. Good, Naritaka Tamaoki, Takuya Maeda, S.M. Rafiqul Islam
TIL-tumor cell coculture resulted in establishment of TIL-iPSCs from tumor-reactive T-cell clones. A, Schematic representation of TIL-tumor cell coculture to isolate tumor-reactive T cells and subsequent reprogramming into iPSCs. Autologous tumor cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ac4669a9add4fdea80a352cc20ba6a
https://doi.org/10.1158/2767-9764.23185901
https://doi.org/10.1158/2767-9764.23185901
Autor:
Raul Vizcardo, Nicholas P. Restifo, Michael J. Kruhlak, Chengyu Liu, Nicole M. Bedanova, Marta Bosch-Marce, Zhiya Yu, Biman C. Paria, Rigel J. Kishton, Meghan L. Good, Naritaka Tamaoki, Takuya Maeda, S.M. Rafiqul Islam
Nonspecific TCR stimulation by αCD3 Ab is not suitable for selective reprogramming of tumor-reactive T cells. A, A summary table of top 10 frequent TCRβ sequences in the starting cells, that is, expanded TIL of patient 4069, indicating the CDR3β a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0082040e29ab5d022a7ab46391922cd2
https://doi.org/10.1158/2767-9764.23185904.v1
https://doi.org/10.1158/2767-9764.23185904.v1
Autor:
Raul Vizcardo, Nicholas P. Restifo, Michael J. Kruhlak, Chengyu Liu, Nicole M. Bedanova, Marta Bosch-Marce, Zhiya Yu, Biman C. Paria, Rigel J. Kishton, Meghan L. Good, Naritaka Tamaoki, Takuya Maeda, S.M. Rafiqul Islam
Tumor-infiltrating lymphocytes (TIL) that can recognize and kill tumor cells have curative potential in subsets of patients treated with adoptive cell transfer (ACT). However, lack of TIL therapeutic efficacy in many patients may be due in large part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8aefb6cbf93ea7e3110e6f4ea3b4b7
https://doi.org/10.1158/2767-9764.c.6641825
https://doi.org/10.1158/2767-9764.c.6641825
Autor:
Raul Vizcardo, Nicholas P. Restifo, Michael J. Kruhlak, Chengyu Liu, Nicole M. Bedanova, Marta Bosch-Marce, Zhiya Yu, Biman C. Paria, Rigel J. Kishton, Meghan L. Good, Naritaka Tamaoki, Takuya Maeda, S.M. Rafiqul Islam
TIL stimulated with autologous tumor cell line generated antigen specific iPSC whereas αCD3/28 beads mediated stimulation did not. A, Summary of three candidate TCR pairs identified in TIL-iPSC lines established by different stimulation methods. Bea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097bcc066c305673fed9fde95986ca72
https://doi.org/10.1158/2767-9764.23185895.v1
https://doi.org/10.1158/2767-9764.23185895.v1