Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson's disease.

Autor: Ismael Huertas, Silvia Jesús, Francisco Javier García-Gómez, José Antonio Lojo, Inmaculada Bernal-Bernal, Marta Bonilla-Toribio, Juan Francisco Martín-Rodriguez, David García-Solís, Pilar Gómez-Garre, Pablo Mir

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0175560 (2017)

The dual syndrome hypothesis for cognitive impairment in Parkinson's disease (PD) establishes a dichotomy between a frontrostriatal dopamine-mediated syndrome, which leads to executive deficits, and a posterior cortical syndrome, which leads to demen

Externí odkaz: https://doaj.org/article/f07f0c43b0e042e88b1c07b4109e64ec

Peripheral inflammatory immune response differs among sporadic and familial Parkinson’s disease

Autor: Laura Muñoz-Delgado, Daniel Macías-García, María Teresa Periñán, Silvia Jesús, Astrid D. Adarmes-Gómez, Marta Bonilla Toribio, Dolores Buiza Rueda, María del Valle Jiménez-Jaraba, Belén Benítez Zamora, Rafael Díaz Belloso, Sergio García-Díaz, Miguel Martín-Bórnez, Rocío Pineda Sánchez, Fátima Carrillo, Pilar Gómez-Garre, Pablo Mir

Publikováno v: npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-9 (2023)

Abstract Peripheral inflammatory immune responses are thought to play a major role in the pathogenesis of Parkinson’s disease (PD). The neutrophil-to-lymphocyte ratio (NLR), a biomarker of systemic inflammation, has been reported to be higher in pa

Externí odkaz: https://doaj.org/article/52eba1144fa34462b2f4bc237ba2e7c9

Smoking is associated with age at disease onset in Parkinson's disease

Autor: Irene Rosas, Germán Morís, Eliecer Coto, Marta Blázquez-Estrada, Esther Suárez, Ciara García-Fernández, Carmen Martínez, Israel Duarte Herrera, Sergio Pérez-Oliveira, Victoria Álvarez, Manuel Menéndez-González, Astrid D. Adarmes-Gómez, Miquel Aguilar, Ignacio Alvarez, Francisco Javier Barrero, Jesús Alberto Bergareche Yarza, Marta Bonilla-Toribio, Juan A. Botía, María Teresa Boungiorno, Dolores Buiza-Rueda, Ana Cámara, Fátima Carrillo, Debora Cerdan, Jordi Clarimón, Yaroslau Compta, Monica Diez-Fairen, Oriol Dols-Icardo, Oriol de Fabregues, Pilar Sanz Cartagena, Jacinto Duarte, Raquel Duran, Francisco Escamilla-Sevilla, Mario Ezquerra, Cici Feliz, Rubén Fernández-Santiago, Manel Fernández, Pedro García-Ruiz, Pilar Gómez-Garre, Maria Jose Gomez Heredia, Isabel Gonzalez-Aramburu, Ana Gorostidi, Janet Hoenicka, Jon Infante, Silvia Jesús, Adriano Jimenez-Escrig, Jaime Kulisevsky, Miguel A. Labrador-Espinosa, Jose Luis Lopez-Sendon, Adolfo López de Munain, Daniel Macias-Garcia, Irene Martínez-Torres, Juan Marín, Maria Jose Marti, Juan Carlos Martínez-Castrillo, Marina Mata Álvarez-Santullano, Adolfo Mínguez-Castellanos, Pablo Mir, Elisabet Mondragon Rezola, Esteban Muñoz, Javier Pagonabarraga, Pau Pastor, Francisco Perez Errazquin, Maria Teresa Periñán, Javier Ruiz-Martínez, Clara Ruz, Antonio Sanchez Rodriguez, María Sierra, Cesar Tabernero, Juan Pablo Tartari, Eduard Tolosa, Francesc Valldeoriola, Lydia Vela, Francisco Vives, Berta Pascual-Sedano, Jorge Hernández-Vara, Dolores Vilas Rolán, Sara Bandrés-Ciga

Publikováno v: Parkinsonism & Related Disorders. 97:79-83

[Background] Previous studies linked disease-progression variables such as age at onset or survival to both genetic, and non-genetic factors in Parkinson's disease (PD) patients.
[Objective] The aim of this study was to assess how genetic and no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1096cb98a9c7c672b37a277e26f74aba
https://doi.org/10.1016/j.parkreldis.2022.03.005

Reply to: 'Increased Stroke Risk in Patients with Parkinson's Disease with LRRK2 Mutations'

Autor: Daniel Macías‐García, María Teresa Periñán, Laura Muñoz‐Delgado, Silvia Jesús, María Valle Jimenez‐Jaraba, Dolores Buiza‐Rueda, Marta Bonilla‐Toribio, Astrid Adarmes‐Gómez, Fátima Carrillo, Pilar Gómez‐Garre, Pablo Mir

Publikováno v: Movement disorders : official journal of the Movement Disorder SocietyReferences. 37(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596848da62fe5408a7dc4cc7a39349bb
https://pubmed.ncbi.nlm.nih.gov/35587629

A geroscience approach for Parkinson's disease: Conceptual framework and design of PROPAG-AGEING project

Autor: Chiara Pirazzini, Tiago Azevedo, Luca Baldelli, Anna Bartoletti-Stella, Giovanna Calandra-Buonaura, Alessandra Dal Molin, Giovanna Maria Dimitri, Ivan Doykov, Pilar Gómez-Garre, Sara Hägg, Jenny Hällqvist, Claire Halsband, Wendy Heywood, Silvia Jesús, Juulia Jylhävä, Katarzyna Malgorzata Kwiatkowska, Miguel A. Labrador-Espinosa, Cristina Licari, Maria Giovanna Maturo, Giacomo Mengozzi, Gaia Meoni, Maddalena Milazzo, Maria Teresa Periñán-Tocino, Francesco Ravaioli, Claudia Sala, Luisa Sambati, Sebastian Schade, Sebastian Schreglmann, Simeon Spasov, Leonardo Tenori, Dylan Williams, Luciano Xumerle, Elisa Zago, Kailash P. Bhatia, Sabina Capellari, Pietro Cortelli, Paolo Garagnani, Henry Houlden, Pietro Liò, Claudio Luchinat, Massimo Delledonne, Kevin Mills, Pablo Mir, Brit Mollenhauer, Christine Nardini, Nancy L. Pedersen, Federica Provini, Stephen Strom, Claudia Trenkwalder, Paola Turano, Maria Giulia Bacalini, Claudio Franceschi, Astrid Adarmes-Gómez, Marta Bonilla-Toribio, Claudia Boninsegna, Marcella Broli, Dolores Buiza-Rueda, Mario Carrión-Claro, Rosalia Cilea, Robert Clayton, Silvia De Luca, Patrizia De Massis, Rocio Escuela-Martin, Giovanni Fabbri, Anna Gabellini, Cristina Giuliani, Pietro Guaraldi, Ismae Huertas, Daniel Macias, Stefania Macrì, Francesca Magrinelli, Juan Francisco Martín Rodríguez, Francesco Mignani, Stefania Alessandra Nassetti, Cesa Lorella Maria Scaglione, Cristina Tejera-Parrado, Franco Valzania, Rosario Vigo Ortega

Publikováno v: Mechanisms of ageing and development
194 (2021). doi:10.1016/j.mad.2020.111426
info:cnr-pdr/source/autori:Pirazzini, Chiara; Azevedo, Tiago; Baldelli, Luca; Bartoletti-Stella, Anna; Calandra-Buonaura, Giovanna; Dal Molin, Alessandra; Dimitri, Giovanna Maria; Doykov, Ivan; Gómez-Garre, Pilar; Hägg, Sara; Hällqvist, Jenny; Halsband, Claire; Heywood, Wendy; Jesús, Silvia; Jylhävä, Juulia; Kwiatkowska, Katarzyna Malgorzata; Labrador-Espinosa, Miguel A.; Licari, Cristina; Maturo, Maria Giovanna; Mengozzi, Giacomo; Meoni, Gaia; Milazzo, Maddalena; Periñán-Tocino, Maria Teresa; Ravaioli, Francesco; Sala, Claudia; Sambati, Luisa; Schade, Sebastian; Schreglmann, Sebastian; Spasov, Simeon; Tenori, Leonardo; Williams, Dylan; Xumerle, Luciano; Zago, Elisa; Bhatia, Kailash P.; Capellari, Sabina; Cortelli, Pietro; Garagnani, Paolo; Houlden, Henry; Liò, Pietro; Luchinat, Claudio; Delledonne, Massimo; Mills, Kevin; Mir, Pablo; Mollenhauer, Brit; Nardini, Christine; Pedersen, Nancy L.; Provini, Federica; Strom, Stephen; Trenkwalder, Claudia; Turano, Paola; Bacalini, Maria Giulia; Franceschi, Claudio; Adarmes-Gómez, Astrid; Bonilla-Toribio, Marta; Boninsegna, Claudia; Broli, Marcella; Buiza-Rueda, Dolores; Carrión-Claro, Mario; Cilea, Rosalia; Clayton, Robert; Molin, Alessandra Dal; De Luca, Silvia; De Massis, Patrizia; Escuela-Martin, Rocio; Fabbri, Giovanni; Gabellini, Anna; Giuliani, Cristina; Guaraldi, Pietro; Huertas, Ismae; Macias, Daniel; Macrì, Stefania; Magrinelli, Francesca; Rodríguez, Juan Francisco Martín; Mignani, Francesco; Nassetti, Stefania Alessandra; Scaglione, Cesa Lorella Maria; Tejera-Parrado, Cristina; Valzania, Franco; Ortega, Rosario Vigo/titolo:A geroscience approach for Parkinson's disease: Conceptual framework and design of PROPAG-AGEING project/doi:10.1016%2Fj.mad.2020.111426/rivista:Mechanisms of ageing and development (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:194

Advanced age is the major risk factor for idiopathic Parkinson's disease (PD), but to date the biological relationship between PD and ageing remains elusive. Here we describe the rationale and the design of the H2020 funded project "PROPAG-AGEING", w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab42111826f022ce26b166f667a14efe
https://pubmed.ncbi.nlm.nih.gov/33385396