A chimeric mouse model to study human iPSC-derived neurons: the case of a truncating SHANK3 mutation

Autor: Jean-Pierre Bourgeois, Nathalie Lemière, Stéphanie Pons, Isabelle Cloëz-Tayarani, Uwe Maskos, Marta Balkota, Aline Vitrac, Célia Raïs, Thomas Bourgeron

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.13315. ⟨10.1038/s41598-020-70056-4⟩
Scientific Reports, 2020, 10 (1), pp.13315. ⟨10.1038/s41598-020-70056-4⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)

Using human induced pluripotent stem cells (iPSC), recent studies have shown that the events underlying autism spectrum disorders (ASD) can occur during neonatal development. We previously analyzed the iPSC-derived pyramidal cortical neurons of a sub

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https://hal-pasteur.archives-ouvertes.fr/pasteur-02913616/document