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Autor:
Arno A. J. van der Ark, Bernard A. M. van der Zeijst, Monamaris M. Borges, Waldely O. Dias, Wagner Quintilio, Noemi Furuyama, Marta Antoniazi, Flávia Saldanha Kubrusly, Maria Aparecida Sakauchi, Ana Fabíola R. O. Prestes, Isaias Raw, Denise S. P. Q. Horton, Betsy Kuipers
Publikováno v:
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Human Vaccines & Immunotherapeutics
Human Vaccines and Immunotherapeutics, 9(2), 339-348
Human Vaccines & Immunotherapeutics
Human Vaccines and Immunotherapeutics, 9(2), 339-348
An improved whole cell pertussis vaccine, designated as Plow, which is low in endotoxicity due to a chemical extraction of lipo-oligosaccharide (LOS) from the outer membrane, was evaluated for safety, immunogenicity and potency, comparatively to a tr