Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Marta Anglada‐Huguet"'
RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer’s disease
Autor:
Leticia Pérez-Sisqués, Anna Sancho-Balsells, Júlia Solana-Balaguer, Genís Campoy-Campos, Marcel Vives-Isern, Ferran Soler-Palazón, Marta Anglada-Huguet, Miguel-Ángel López-Toledano, Eva-Maria Mandelkow, Jordi Alberch, Albert Giralt, Cristina Malagelada
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Abstract RTP801/REDD1 is a stress-regulated protein whose upregulation is necessary and sufficient to trigger neuronal death. Its downregulation in Parkinson’s and Huntington’s disease models ameliorates the pathological phenotypes. In the contex
Externí odkaz:
https://doaj.org/article/dd2fb29473404df5adcecc84c09efbe1
Autor:
Claudia Green, Astrid Sydow, Stefanie Vogel, Marta Anglada-Huguet, Dirk Wiedermann, Eckhard Mandelkow, Eva-Maria Mandelkow, Mathias Hoehn
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-13 (2019)
Abstract Background Aggregation of tau proteins is a distinct hallmark of tauopathies and has been a focus of research and clinical trials for Alzheimer’s Disease. Recent reports have pointed towards a toxic effect of soluble or oligomeric tau in t
Externí odkaz:
https://doaj.org/article/b4dfec4265824357ac8bceee89b61f95
Autor:
Marta Anglada‐Huguet, Sara Rodrigues, Katja Hochgräfe, Eckhard Mandelkow, Eva‐Maria Mandelkow
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 7, Iss 1, Pp n/a-n/a (2021)
Abstract Background One of the major hallmarks of Alzheimer's disease (AD)is the aberrant modification and aggregation of the microtubule‐associated protein Tau . The extent of Tau pathology correlates with cognitive decline, strongly implicating T
Externí odkaz:
https://doaj.org/article/a12f11c1fb304a38b4035099f2c68007
Autor:
Maria Joseph, Marta Anglada-Huguet, Katharina Paesler, Eckhard Mandelkow, Eva-Maria Mandelkow
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-19 (2017)
Abstract Background The microtubule-associated protein Tau plays a role in neurodegeneration as well as neurogenesis. Previous work has shown that the expression of the pro-aggregant mutant Tau repeat domain causes strong aggregation and pronounced n
Externí odkaz:
https://doaj.org/article/9b71cdd64e4840809a668b9b7d79833d
Autor:
Marta Anglada-Huguet, Laura Vidal-Sancho, Albert Giralt, Gerardo García-Díaz Barriga, Xavier Xifró, Jordi Alberch
Publikováno v:
Neurobiology of Disease, Vol 95, Iss , Pp 22-34 (2016)
Huntington's disease (HD) patients and mouse models show learning and memory impairment even before the onset of motor symptoms. Deficits in hippocampal synaptic plasticity have been involved in the HD memory impairment. Several studies show that pro
Externí odkaz:
https://doaj.org/article/cb2389e17973429a90512f8b43474e9a
Autor:
Marta Anglada-Huguet, Heike Endepols, Astrid Sydow, Ronja Hilgers, Bernd Neumaier, Alexander Drzezga, Senthilvelrajan Kaniyappan, Eckhard Mandelkow, Eva-Maria Mandelkow
Publikováno v:
International journal of molecular sciences 24(11), 9260-(2023). doi:10.3390/ijms24119260
International journal of molecular sciences 24(11), 9260 (2023). doi:10.3390/ijms24119260 special issue: "Transgenic Mice in Human Diseases: Insights from Molecular Research 4.0"
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9260
International Journal of Molecular Sciences
International journal of molecular sciences 24(11), 9260 (2023). doi:10.3390/ijms24119260 special issue: "Transgenic Mice in Human Diseases: Insights from Molecular Research 4.0"
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9260
International Journal of Molecular Sciences
The accumulation of tau is a hallmark of several neurodegenerative diseases and is associated with neuronal hypoactivity and presynaptic dysfunction. Oral administration of the adenosine A1 receptor antagonist rolofylline (KW-3902) has previously bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cc758d5fe7540190cd71e87f073c94
https://juser.fz-juelich.de/record/1008614
https://juser.fz-juelich.de/record/1008614
Autor:
Marta Anglada-Huguet, Heike Endepols, Astrid Sydow, Ronja Hilgers, Bernd Neumaier, Alexander Drzezga, Senthilvelrajan Kaniyappan, Eckhard Mandelkow, Eva-Maria Mandelkow
Background: Accumulation of tau is a characteristic hallmark of several neurodegenerative diseases and is associated with neuronal hypoactivity and presynaptic dysfunction. Oral administration of the adenosine A1 receptor antagonist rolofylline (KW-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::285150ff57a42fbc49f96fc39b19e86f
https://doi.org/10.21203/rs.3.rs-1363420/v1
https://doi.org/10.21203/rs.3.rs-1363420/v1
Autor:
Heike Endepols, Marta Anglada-Huguet, Eckhard Mandelkow, Yannick Schmidt, Philipp Krapf, Boris D. Zlatopolskiy, Bernd Neumaier, Eva-Maria Mandelkow, Alexander Drzezga
Publikováno v:
Molecular neurobiology 59, 3402-3413 (2022). doi:10.1007/s12035-022-02793-8
Molecular Neurobiology
Molecular neurobiology 59(6), 3402-3413 (2022). doi:10.1007/s12035-022-02793-8
Molecular Neurobiology
Molecular neurobiology 59(6), 3402-3413 (2022). doi:10.1007/s12035-022-02793-8
Abstract Cerebral glucose hypometabolism is a typical hallmark of Alzheimer’s disease (AD), usually associated with ongoing neurodegeneration and neuronal dysfunction. However, underlying pathological processes are not fully understood and reproduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749291184c89371a15a987fd79988b50
RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer’s disease
Autor:
Genís Campoy-Campos, Marta Anglada-Huguet, Miguel-Ángel López-Toledano, Eva-Maria Mandelkow, Anna Sancho-Balsells, Júlia Solana-Balaguer, Ferran Soler-Palazón, Leticia Pérez-Sisqués, Jordi Alberch, Cristina Malagelada, Albert Giralt, Marcel Vives-Isern
Publikováno v:
Cell Death & Disease
Cell death & disease 12(6), 616 (2021). doi:10.1038/s41419-021-03899-y
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Cell Death and Disease
Cell death & disease 12(6), 616 (2021). doi:10.1038/s41419-021-03899-y
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Cell Death and Disease
RTP801/REDD1 is a stress-regulated protein whose upregulation is necessary and sufficient to trigger neuronal death. Its downregulation in Parkinson’s and Huntington’s disease models ameliorates the pathological phenotypes. In the context of Alzh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c1f33bee35f24c79ef49b0cf714a3a
https://doi.org/10.1038/s41419-021-03899-y
https://doi.org/10.1038/s41419-021-03899-y
Autor:
Senthilvelrajan Kaniyappan, Marta Anglada-Huguet, Sara Rodrigues, Susanne Wegmann, Katja Hochgräfe, Eva-Maria Mandelkow
Background: The stereotypical progression of Tau pathology during Alzheimer disease has been attributed to trans-neuronal spreading of misfolded Tau proteins, followed by prion-like templated aggregation of Tau. The nature of Tau and the cellular mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e94febd123312d06f89b683c6569cfe1
https://doi.org/10.21203/rs.3.rs-356350/v1
https://doi.org/10.21203/rs.3.rs-356350/v1