Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Marta Alegret"'
Autor:
Roger Bentanachs, Lluïsa Miró, Rosa M. Sánchez, Patricia Ramírez-Carrasco, Concepció Amat, Marta Alegret, Anna Pérez, Núria Roglans, Juan C. Laguna
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117067- (2024)
Background and aims: Drugs resolving steatotic liver disease (SLD) could prevent the evolution of metabolic dysfunction associated SLD (MASLD) to more aggressive forms but must show not only efficacy, but also a high safety profile. Repurposing of dr
Externí odkaz:
https://doaj.org/article/5df01807c6744dbc8f567596638bf3f0
Autor:
Benedetta Di Veroli, Roger Bentanachs, Núria Roglans, Marta Alegret, Letizia Giona, Elisabetta Profumo, Alessandra Berry, Luciano Saso, Juan Carlos Laguna, Brigitta Buttari
Publikováno v:
Cells, Vol 13, Iss 15, p 1247 (2024)
Sex differences may play a role in the etiopathogenesis and severity of metabolic dysfunction-associated steatotic liver disease (MASLD), a disorder characterized by excessive fat accumulation associated with increased inflammation and oxidative stre
Externí odkaz:
https://doaj.org/article/b0fbd2a3d6024cabbbb7802811c6b8d8
Autor:
Roger Bentanachs, Laia Blanco, Maria Montesinos, Aleix Sala-Vila, Iolanda Lázaro, Jose Rodríguez-Morató, Rosa María Sánchez, Juan Carlos Laguna, Núria Roglans, Marta Alegret
Publikováno v:
Nutrients, Vol 15, Iss 18, p 3909 (2023)
Non-alcoholic fatty liver disease is a sexual dimorphic disease, with adipose tissue playing an essential role. Our previous work showed that female rats fed a high-fat high-fructose diet devoid of cholesterol (HFHFr) developed simple hepatic steatos
Externí odkaz:
https://doaj.org/article/0cfedb24484740ed8fa3ee97376c2b28
Autor:
Nuria Roglans, Miguel Baena, Gemma Sangüesa, Ana Magdalena Velázquez, Christian Griñán-Ferré, Mercè Pallàs, Rosa María Sánchez, Marta Alegret, Juan Carlos Laguna
Publikováno v:
Food & Nutrition Research, Vol 65, Pp 1-15 (2021)
Background: Non-alcoholic fatty liver disease (NAFLD) has increased over the last decades and may evolve into hepatocellular carcinoma (HCC). As HCC is challenging to treat, knowledge on the modifiable risk factors for NAFLD/HCC (e.g. hyper caloric d
Externí odkaz:
https://doaj.org/article/f1c37e51f156493784fda254eeeaf8d5
Autor:
Núria Roglans, Elena Fauste, Roger Bentanachs, Ana M. Velázquez, Madelin Pérez-Armas, Cristina Donis, María I. Panadero, Marta Alegret, Paola Otero, Carlos Bocos, Juan C. Laguna
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 473 (2022)
We previously demonstrated that treatment with BemA (bempedoic acid), an inhibitor of ATP citrate lyase, significantly reduces fatty liver in a model of liver steatosis (HFHFr—female Sprague-Dawley rat fed a high-fat high-fructose diet). Since the
Externí odkaz:
https://doaj.org/article/099727e40dd74b5b81636f3371b79327
Autor:
Ana Magdalena Velázquez, Roger Bentanachs, Aleix Sala-Vila, Iolanda Lázaro, Jose Rodríguez-Morató, Rosa María Sánchez, Juan Carlos Laguna, Núria Roglans, Marta Alegret
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1517 (2022)
Bempedoic acid (BemA) is an ATP-citrate lyase (ACLY) inhibitor used to treat hypercholesterolemia. We studied the anti-steatotic effect of BemA, and the mechanisms involved, in a model of fatty liver in female rats obtained through the administration
Externí odkaz:
https://doaj.org/article/4a40e317c75a44f4878f7270f8c3a005
Autor:
Ana Magdalena Velázquez, Núria Roglans, Roger Bentanachs, Maria Gené, Aleix Sala-Vila, Iolanda Lázaro, Jose Rodríguez-Morató, Rosa María Sánchez, Juan Carlos Laguna, Marta Alegret
Publikováno v:
Nutrients, Vol 12, Iss 11, p 3240 (2020)
Non-alcoholic fatty liver disease is a highly prevalent condition without specific pharmacological treatment, characterized in the initial stages by hepatic steatosis. It was suggested that lipid infiltration in the liver might be reduced by caffeine
Externí odkaz:
https://doaj.org/article/81aeceb9683546b4ad6f32b07d9dba77
Publikováno v:
Nutrients, Vol 6, Iss 12, Pp 5933-5954 (2014)
Sugar intake has dramatically increased during the last few decades. Specifically, there has been a clear trend towards higher consumption of fructose and high fructose corn syrup, which are the most common added sugars in processed food, soft drinks
Externí odkaz:
https://doaj.org/article/c8d16170298347a69f40942b14c853ca
Autor:
Gemma Sangüesa, Núria Roglans, Miguel Baena, Ana Magdalena Velázquez, Juan Carlos Laguna, Marta Alegret
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 5, p 1117 (2019)
One of the most important threats to global human health is the increasing incidences of metabolic pathologies (including obesity, type 2 diabetes and non-alcoholic fatty liver disease), which is paralleled by increasing consumptions of hypercaloric
Externí odkaz:
https://doaj.org/article/d10386fecb6e418c9fe3dd19b450c495
Autor:
Gemma Llaverias, Manuel Vázquez-Carrera, Rosa M. Sánchez, Véronique Noé, Carlos J. Ciudad, Juan C. Laguna, Marta Alegret
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 11, Pp 2015-2024 (2004)
Peroxisome proliferator-activated receptor γ (PPARγ) activation or overexpression induces caveolin-1 (cav-1) expression in several cell types. The objective of this study was to investigate if PPAR agonists could also regulate the cav-1 gene in mac
Externí odkaz:
https://doaj.org/article/2d424694008f45528f41eed9f6ec29f2