Single cell profiling reveals a reduction of CD56dim NK-cells and other immune cells in patients with Meniere disease and high levels of cytokines

Autor: Marisa Flook, Alba Escalera-Balsera, Paulina Rybakowska, Lidia Frejo, Angel Batuecas-Caletrio, Juan Carlos Amor-Dorado, Andres Soto-Varela, Marta Alarcón-Riquelme, Jose Antonio Lopez-Escamez

Background Meniere Disease (MD) is an inner ear syndrome, characterized by sensorineural hearing loss associated with episodes of vertigo, tinnitus, and aural fullness. The pathological mechanism leading to sporadic MD is still poorly understood, how

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9bbb04d1802cdda3ef55fbde10b92358
https://doi.org/10.21203/rs.3.rs-2210600/v1

Standardization procedure for flow cytometry data harmonization in prospective multicenter studies

Autor: Lucas Le Lann, Pierre-Emmanuel Jouve, Marta Alarcón-Riquelme, Christophe Jamin, Jacques-Olivier Pers, Blanco Alonso, Ricardo, González-Gay Mantecón, Miguel Ángel

Publikováno v: Scientific Reports 10, 11567 (2020).
UCrea Repositorio Abierto de la Universidad de Cantabria
instname
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)

One of the most challenging objective for clinical cytometry in prospective multicenter immunomonitoring trials is to compare frequencies, absolute numbers of leukocyte populations and further the mean fluorescence intensities of cell markers, especi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6fe3f43a216c3734e7a3e0e294e194d3
https://www.nature.com/articles/s41598-020-68468-3.pdf

Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis

Autor: Maureen D. Mayes, Lara Bossini-Castillo, Olga Gorlova, José Ezequiel Martin, Xiaodong Zhou, Wei V. Chen, Shervin Assassi, Jun Ying, Filemon K. Tan, Frank C. Arnett, John D. Reveille, Sandra Guerra, María Teruel, Francisco David Carmona, Peter K. Gregersen, Annette T. Lee, Elena López-Isac, Eguzkine Ochoa, Patricia Carreira, Carmen Pilar Simeón, Iván Castellví, Miguel Ángel González-Gay, Alexandra Zhernakova, Leonid Padyukov, Marta Alarcón-Riquelme, Cisca Wijmenga, Matthew Brown, Lorenzo Beretta, Gabriela Riemekasten, Torsten Witte, Nicolas Hunzelmann, Alexander Kreuter, Jörg H.W. Distler, Alexandre E. Voskuyl, Annemie J. Schuerwegh, Roger Hesselstrand, Annika Nordin, Paolo Airó, Claudio Lunardi, Paul Shiels, Jacob M. van Laar, Ariane Herrick, Jane Worthington, Christopher Denton, Fredrick M. Wigley, Laura K. Hummers, John Varga, Monique E. Hinchcliff, Murray Baron, Marie Hudson, Janet E. Pope, Daniel E. Furst, Dinesh Khanna, Kristin Phillips, Elena Schiopu, Barbara M. Segal, Jerry A. Molitor, Richard M. Silver, Virginia D. Steen, Robert W. Simms, Robert A. Lafyatis, Barri J. Fessler, Tracy M. Frech, Firas AlKassab, Peter Docherty, Elzbieta Kaminska, Nader Khalidi, Henry Niall Jones, Janet Markland, David Robinson, Jasper Broen, Timothy R.D.J. Radstake, Carmen Fonseca, Bobby P. Koeleman, Javier Martin, Norberto Ortego-Centeno, Raquel Ríos, José Luis Callejas, Nuria Navarrete, Rosa García Portales, María Teresa Camps, Antonio Fernández-Nebro, María F. González-Escribano, Julio Sánchez-Román, Francisco José García-Hernández, María Jesús Castillo, María Ángeles Aguirre, Inmaculada Gómez-Gracia, Benjamín Fernández-Gutiérrez, Luis Rodríguez-Rodríguez, Esther Vicente, José Luis Andreu, Mónica Fernández de Castro, Paloma García de la Peña, Francisco Javier López-Longo, Lina Martínez, Vicente Fonollosa, Gerard Espinosa, Carlos Tolosa, Anna Pros, Mónica Rodríguez Carballeira, Francisco Javier Narváez, Manel Rubio Rivas, Vera Ortiz Santamaría, Bernardino Díaz, Luis Trapiella, María del Carmen Freire, Adrián Sousa, María Victoria Egurbide, Patricia Fanlo Mateo, Luis Sáez-Comet, Federico Díaz, Vanesa Hernández, Emma Beltrán, José Andrés Román-Ivorra, Elena Grau, Juan José Alegre Sancho, Francisco J. Blanco García, Natividad Oreiro, Luis Fernández Sueiro

Publikováno v: Mayes, M D, Bossini-Castillo, L, Gorlova, O, Martin, J E, Zhou, X D, Chen, W V, Assassi, S, Ying, J, Tan, F K, Arnett, F C, Reveille, J D, Guerra, S, Terue, M, Carmona, F D, Gregersen, P K, Lee, A T, Lopez-Isac, E, Ochoa, E, Carreira, P, Simeon, C P, Castellvi, I, Gonzalez-Gay, M A, Zhernakova, A, Padyukov, L, arcon-Riquelme, M, Wijmenga, C, Brown, M, Beretta, L, Riemekasten, G, Witte, T, Hunzelmann, N, Kreuter, A, Distler, J H W, Voskuyl, A E, Schuerwegh, A J, Hesselstrand, R, Nordin, A, Airo, P, Lunardi, C, Shiels, P, van Laar, J M, Herrick, A, Worthington, J, Denton, C, Wigley, F M, Hummers, L K, Varga, J, Hinchcliff, M E, Baron, M, Hudson, M, Pope, J E, Furst, DE, Khanna, D, Phillips, K, Schiopu, E, Segal, B M, Molitor, J A, Silver, R M, Steen, V D, Simms, R W, Lafyatis, R A, Fessler, B I J, Frech, T M, AlKassab, F, Docherty, P, Kaminska, E, Khalidi, N, Jones, H N, Markland, J, Robinson, D, Broen, J, Radstake, T R D J, Fonseca, C, Koeleman, BP & Martin, J 2014, ' Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis ', American journal of human genetics, vol. 94, no. 1, pp. 47-61 . https://doi.org/10.1016/j.ajhg.2013.12.002
American journal of human genetics, 94(1), 47-61. Cell Press
AMERICAN JOURNAL OF HUMAN GENETICS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
American Journal of Human Genetics, 94(1), 47-61. CELL PRESS
American Journal of Human Genetics, 94(1), 47-61

In this study, 1,833 systemic sclerosis (SSc) cases and 3,466 controls were genotyped with the Immunochip array. Classical alleles, amino acid residues, and SNPs across the human leukocyte antigen (HLA) region were imputed and tested. These analyses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6939d4b4c770d281595dee1bc71cee
https://research.vumc.nl/en/publications/81e9c026-1180-45c0-9c4c-8e4e9a9b7152

BANK1 transgenic mice exhibit lupus-associated B cell phenotypes (BA3P.105)

Autor: Simanta Pathak, Yuyuan Guo, Huihua Ding, Yong Du, Soyoun Min, Kamala Vanarsa, Quanzhen Li, Sergey Kozyrev, Marta Alarcón-Riquelme, Chandra Mohan

Publikováno v: The Journal of Immunology. 194:46.2-46.2

BANK1 is a B-cell adaptor protein that has been implicated in SLE and systemic sclerosis. Previous studies have interpreted that the overexpression of the full length BANK1 isoform plays a pathogenic and the truncated (∆BANK1) version plays a prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::659cc83a4e72902e42ed81c8184b9c01
https://doi.org/10.4049/jimmunol.194.supp.46.2

Association of the PD-1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope

Autor: Ludmila, Prokunina, Leonid, Padyukov, Anna, Bennet, Ulf, de Faire, Björn, Wiman, Jonathan, Prince, Lars, Alfredsson, Lars, Klareskog, Marta, Alarcón-Riquelme

Publikováno v: Arthritis and rheumatism. 50(6)

To study the frequency of allele A of polymorphism PD-1.3 of the PDCD1 gene in patients with rheumatoid arthritis (RA) and its subsets, based on the presence of rheumatoid factor (RF) and the shared epitope (SE) alleles.A total of 1,175 patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a153c369f5e269159d034e35aa233220
https://pubmed.ncbi.nlm.nih.gov/15188352