Re-designing environmentally persistent pharmaceutical pollutant through programmed inactivation: The case of methotrexate

Autor: Anaïs Espinosa, Estelle Rascol, Marta Abellán Flos, Charles Skarbek, Pascale Lieben, Eva Bannerman, Alba Diez Martinez, Stéphanie Pethe, Pierre Benoit, Sylvie Nélieu, Raphaël Labruère

Publikováno v: Chemosphere. 306:135616

Environmental emission of pharmaceutical pollutants notably causes the contamination of aquatic ecosystems and drinking water. Typically, reduction of these pollutants in the environment is mostly managed by ameliorated wastewater treatments. Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca8f90c290c919afcad2d82f751add4
https://doi.org/10.1016/j.chemosphere.2022.135616

Potent Glycosidase Inhibition with Heterovalent Fullerenes: Unveiling the Binding Modes Triggering Multivalent Inhibition

Autor: M. Isabel García Moreno, Jean-François Nierengarten, José M. García Fernández, Stéphane P. Vincent, Marta Abellán Flos, Carmen Ortiz Mellet

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Glycosidases are key enzymes in metabolism, pathogenic/antipathogenic mechanisms and normal cellular functions. Recently, a novel approach for glycosidase inhibition that conveys multivalent glycomimetic conjugates has emerged. Many questions regardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb02737f71303be659d3a5a668a1ec5
https://doi.org/10.1002/chem.201601673

Multimeric xanthates as carbonic anhydrase inhibitors

Autor: Stéphane P. Vincent, Muhammet Tanc, Claudiu T. Supuran, Marta Abellán-Flos

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry. 31:946-952

The field of multivalent inhibition of enzymes is growing exponentially from the first reported multivalent effect on a glycosidase enzyme. However, the investigations have generally remained restricted to carbohydrate-processing enzymes. Carbonic an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35879d5a96da5188e89d7690a4193cd
https://doi.org/10.3109/14756366.2015.1072177

Forces in yeast flocculation

Autor: Sofiane El-Kirat-Chatel, Audrey Beaussart, Yves F. Dufrêne, Peter N. Lipke, Pascal Hols, Marta Abellán Flos, Stéphane P. Vincent

Publikováno v: Nanoscale. 7:1760-1767

In the baker's yeast Saccharomyces cerevisiae, cell-cell adhesion ("flocculation") is conferred by a family of lectin-like proteins known as the flocculin (Flo) proteins. Knowledge of the adhesive and mechanical properties of flocculins is important

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afba06bd5405099f271aa99de20c10b3
https://doi.org/10.1039/c4nr06315e

Force Nanoscopy as a Versatile Platform for Quantifying the Activity of Antiadhesion Compounds Targeting Bacterial Pathogens

Autor: Audrey Beaussart, Sofiane El-Kirat-Chatel, Stéphane P. Vincent, Yves F. Dufrêne, Marta Abellán-Flos

Publikováno v: Nano Letters
Nano Letters, American Chemical Society, 2016, 16 (2), pp.1299-1307. ⟨10.1021/acs.nanolett.5b04689⟩
Nano Letters, 2016, 16 (2), pp.1299-1307. ⟨10.1021/acs.nanolett.5b04689⟩

International audience; The development of bacterial strains that are resistant to multiple antibiotics has urged the need for new antibacterial therapies. An exciting approach to fight bacterial diseases is the use of antiadhesive agents capable to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0561f9d774cd75cddad0ac19ddef810e
https://pubmed.ncbi.nlm.nih.gov/26812480