Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Marta A. Gaertig"'
Autor:
Su Yang, Huiming Yang, Renbao Chang, Peng Yin, Yang Yang, Weili Yang, Shanshan Huang, Marta A. Gaertig, Shihua Li, Xiao-Jiang Li
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
MANF is a neurotrophic factor that is secreted but also mediates the unfolded protein response acting intracellularly. Here, the authors show that MANF expression in the brain is influenced by nutritional cues, and hypothalamic MANF influences food i
Externí odkaz:
https://doaj.org/article/3145dea6879743cc979c30ea0084a9a5
Publikováno v:
Cell Reports, Vol 13, Iss 1, Pp 196-208 (2015)
In polyglutamine (polyQ) diseases, large polyQ repeats cause juvenile cases with different symptoms than those of adult-onset patients, who carry smaller expanded polyQ repeats. The mechanisms behind the differential pathology mediated by different p
Externí odkaz:
https://doaj.org/article/a28ed78a05c247c4aca1adaa7e249d75
Publikováno v:
Cell Reports, Vol 13, Iss 1, Pp 196-208 (2015)
SummaryIn polyglutamine (polyQ) diseases, large polyQ repeats cause juvenile cases with different symptoms than those of adult-onset patients, who carry smaller expanded polyQ repeats. The mechanisms behind the differential pathology mediated by diff
Autor:
Shihua Li, Xiao-Jiang Li, Marta A. Gaertig, Roger H. Reeves, Jianxing Xiang, Su Yang, Ning Xin
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Huntingtin-associated protein 1 (Hap1) is known to be critical for postnatal hypothalamic function and growth. Hap1 forms stigmoid bodies (SBs), unique neuronal cytoplasmic inclusions of unknown function that are enriched in hypothalamic neurons. Her
Publikováno v:
Neuron. 81:349-365
SummaryAlthough protein-misfolding-mediated neurodegenerative diseases have been linked to aging, how aging contributes to selective neurodegeneration remains unclear. We established spinocerebellar ataxia 17 (SCA17) knockin mice that inducibly expre
Autor:
Ling Weng, Xingshun Xu, Naureen Mitha, Sen Yan, Xiao-Jiang Li, Alina L. Li, Yung Feng Lin, Chuan En Wang, Marta A. Gaertig, Jun Kosaka, Taketoshi Wakabayashi, Shihua Li, Miao Sun, Beisha Tang
Publikováno v:
The Journal of Neuroscience. 33:8172-8184
Mutations in the Abelson helper integration site-1 (AHI1) gene result in N-terminal Ahi1 fragments and cause Joubert syndrome, an autosomal recessive brain malformation disorder associated with delayed development. HowAHI1mutations lead to delayed de
Autor:
Shihua Li, Guohao Wang, Yan Hong, Marta A. Gaertig, Ting Zhao, Miao Sun, Xiao-Jiang Li, Chuan-En Wang, Xudong Liu
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 12, Iss 5, p e1006083 (2016)
PLoS Genetics, Vol 12, Iss 5, p e1006083 (2016)
The Huntington’s disease (HD) protein, huntingtin (HTT), is a large protein consisting of 3144 amino acids and has conserved N-terminal sequences that are followed by a polyglutamine (polyQ) repeat. Loss of Htt is known to cause embryonic lethality
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(12)
The Huntington's disease (HD) protein, huntingtin (HTT), is essential for early development. Because suppressing the expression of mutant HTT is an important approach to treat the disease, we must first understand the normal function of Htt in adults
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 7, p e0134142 (2015)
PLoS ONE, Vol 10, Iss 7, p e0134142 (2015)
Huntington disease (HD) represents a family of neurodegenerative diseases that are caused by misfolded proteins. The misfolded proteins accumulate in the affected brain regions in an age-dependent manner to cause late-onset neurodegeneration. Transge
Publikováno v:
Human molecular genetics. 23(10)
Mutations in TAR DNA-binding protein 43 (TDP-43) are associated with familial forms of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Although recent studies have revealed that mutant TDP-43 in neuronal and glial cells is toxic,