Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption

Autor: Marta A Ślimak, Jessica L Ables, Silke eFrahm, Beatriz eAntolin-Fontes, Julio eSantos-Torres, Milena eMoretti, Cecilia eGotti, Ines eIbañez-Tallon

Publikováno v: Frontiers in Human Neuroscience, Vol 8 (2014)

The CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the α5, α3 and β4 nicotinic acetylcholine receptor (nAChR) subunits, has been linked to nicotine dependence. The habenulo-interpeduncular (Hb-IPN) tract is particularly enriched in α3β4 nAChRs. We

Externí odkaz: https://doaj.org/article/d6e084e02a3749ca99ab6d3e18d55095

Cross-reactivity of acid-sensing ion channel and Na+-H+exchanger antagonists with nicotinic acetylcholine receptors

Autor: Marta A. Ślimak, Sebastian Auer, Julio Santos-Torres, Inés Ibañez-Tallon

Publikováno v: The Journal of Physiology. 589:5109-5123

Nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the mammalian central and peripheral nervous systems, where they contribute to neuronal excitability and synaptic communication. It has been reported that nAChRs are modulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38f807899e84dc2ed338b543d1746526
https://doi.org/10.1113/jphysiol.2011.213272

The biochemical anatomy of cortical inhibitory synapses

Autor: Julio Santos-Torres, Brian T. Chait, Nathaniel Heintz, John C. Earnheart, Fekrije Selimi, Inés Ibañez-Tallon, Wenzhu Zhang, Elizabeth A. Heller, Chiye Aoki, Marta A. Ślimak

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e39572 (2012)
PLoS ONE

Classical electron microscopic studies of the mammalian brain revealed two major classes of synapses, distinguished by the presence of a large postsynaptic density (PSD) exclusively at type 1, excitatory synapses. Biochemical studies of the PSD have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b328677fec973eb1af01ecb2a979257b
http://edoc.mdc-berlin.de/12440/1/12440oa.pdf

Article Aversion to Nicotine Is Regulated by the Balanced Activity of b4 and a5 Nicotinic Receptor Subunits in the Medial Habenula

Autor: Beatriz Antolin-Fontes, Silke Frahm, Leiron Ferrarese, Stéphanie Pons, Inés Ibañez-Tallon, Victor I. Tsetlin, Sergey Yu. Filkin, Marta A. Ślimak, Sebastian Auer, Julio Santos-Torres, Jean-Fred Fontaine, Uwe Maskos

Publikováno v: Neuron
Neuron, 2011, 70 (3), pp.522-535. ⟨10.1016/j.neuron.2011.04.013⟩
Neuron, Elsevier, 2011, 70 (3), pp.522-535. ⟨10.1016/j.neuron.2011.04.013⟩

International audience; Nicotine dependence is linked to single nucleotide polymorphisms in the CHRNB4-CHRNA3-CHRNA5 gene cluster encoding the a3b4a5 nicotinic acetyl-choline receptor (nAChR). Here we show that the b4 subunit is rate limiting for rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2654c695422849a97115b7268bb8cfba
https://hal-pasteur.archives-ouvertes.fr/pasteur-02936508