Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Marta Giorgis"'
Autor:
Mohammad Houshmand, Nicoletta Vitale, Francesca Orso, Alessandro Cignetti, Ivan Molineris, Valentina Gaidano, Stefano Sainas, Marta Giorgis, Donatella Boschi, Carmen Fava, Alice Passoni, Marta Gai, Massimo Geuna, Federica Sora, Alessandra Iurlo, Elisabetta Abruzzese, Massimo Breccia, Olga Mulas, Giovanni Caocci, Fausto Castagnetti, Daniela Taverna, Salvatore Oliviero, Fabrizio Pane, Marco Lucio Lolli, Paola Circosta, Giuseppe Saglio
Publikováno v:
Cell Death and Disease, Vol 13, Iss 6, Pp 1-13 (2022)
Abstract The development of different generations of BCR-ABL1 tyrosine kinase inhibitors (TKIs) has led to the high overall survival of chronic myeloid leukemia (CML) patients. However, there are CML patients who show resistance to TKI therapy and ar
Externí odkaz:
https://doaj.org/article/8b9664dc6202406c8f68c1be24352acf
Autor:
Elisabetta Marini, Marco Marino, Giulia Gionfriddo, Federica Maione, Marta Pandini, Daniele Oddo, Marta Giorgis, Barbara Rolando, Federica Blua, Simone Gastaldi, Serena Marchiò, Sandra Kovachka, Francesca Spyrakis, Eleonora Gianquinto, Federica Di Nicolantonio, Massimo Bertinaria
Publikováno v:
Molecules, Vol 27, Iss 23, p 8513 (2022)
BRAF is a serine/threonine kinase frequently mutated in human cancers. BRAFV600E mutated protein is targeted through the use of kinase inhibitors which are approved for the treatment of melanoma; however, their long-term efficacy is hampered by resis
Externí odkaz:
https://doaj.org/article/321ff11884e9491784732a391526bf64
Autor:
Salvatore Galati, Stefano Sainas, Marta Giorgis, Donatella Boschi, Marco L. Lolli, Gabriella Ortore, Giulio Poli, Tiziano Tuccinardi
Publikováno v:
Molecules, Vol 27, Iss 12, p 3660 (2022)
Human dihydroorotate dehydrogenase (hDHODH) is an enzyme belonging to a flavin mononucleotide (FMN)-dependent family involved in de novo pyrimidine biosynthesis, a key biological pathway for highly proliferating cancer cells and pathogens. In fact, h
Externí odkaz:
https://doaj.org/article/5ea641b6c93a40279f5578d4115b28cb
Autor:
Elisabetta Marini, Marta Giorgis, Marta Leporati, Barbara Rolando, Konstantin Chegaev, Loretta Lazzarato, Massimo Bertinaria, Marco Vincenti, Antonella Di Stilo
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 166 (2022)
Chronic use of glyceryl trinitrate (GTN) is limited by serious side effects, such as tolerance and endothelial dysfunction of coronary and resistance arteries. Although GTN is used as a drug since more than 130 years, the mechanisms of the vasodilato
Externí odkaz:
https://doaj.org/article/6303ba905d82437abd1d85b5f51d93be
Autor:
Stefano Sainas, Marta Giorgis, Paola Circosta, Giulio Poli, Marta Alberti, Alice Passoni, Valentina Gaidano, Agnese C. Pippione, Nicoletta Vitale, Davide Bonanni, Barbara Rolando, Alessandro Cignetti, Cristina Ramondetti, Alessia Lanno, Davide M. Ferraris, Barbara Canepa, Barbara Buccinnà, Marco Piccinini, Menico Rizzi, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Riccardo Miggiano, Tiziano Tuccinardi, Marco L. Lolli
Publikováno v:
Journal of Medicinal Chemistry. 65:12701-12724
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e61aeadeb5c771296d71bc58f9453a
https://doi.org/10.1021/acs.jmedchem.2c00496
https://doi.org/10.1021/acs.jmedchem.2c00496
Autor:
Simone Gastaldi, Valentina Boscaro, Eleonora Gianquinto, Christina F. Sandall, Marta Giorgis, Elisabetta Marini, Federica Blua, Margherita Gallicchio, Francesca Spyrakis, Justin A. MacDonald, Massimo Bertinaria
Publikováno v:
Molecules, Vol 26, Iss 13, p 3975 (2021)
In the search for new chemical scaffolds able to afford NLRP3 inflammasome inhibitors, we used a pharmacophore-hybridization strategy by combining the structure of the acrylic acid derivative INF39 with the 1-(piperidin-4-yl)1,3-dihydro-2H-benzo[d]im
Externí odkaz:
https://doaj.org/article/3c3494cec8624421abf07d12c3ebe214
Autor:
Carolina Pellegrini, Matteo Fornai, Rocchina Colucci, Laura Benvenuti, Vanessa D’Antongiovanni, Gianfranco Natale, Federica Fulceri, Marta Giorgis, Elisabetta Marini, Simone Gastaldi, Massimo Bertinaria, Corrado Blandizzi, Luca Antonioli
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome is pivotal in maintaining intestinal homeostasis and sustaining enteric immune responses in the setting of inflammatory bowel dis
Externí odkaz:
https://doaj.org/article/87239b7fac1d4ddc9c7d0f80aba67650
Autor:
Marta Giorgis, Donatella Boschi, Barbara Buccinnà, Stefano Sainas, Mariia Mishina, Davide Bonanni, Alice Passoni, Salam Al-Karadaghi, Yaqi Qiu, Cristina Ramondetti, Paola Circosta, Giuseppe Saglio, Marco Piccinini, Valentina Gaidano, Mohammad Houshmand, Alessandro Bona, Alessandro Cignetti, Enrico Giraudo, Carina Florina Cojocaru, Marco Lucio Lolli, Barbara Rolando, Renzo Bagnati, Agnese Chiara Pippione, Barbara Canepa
Publikováno v:
Journal of Medicinal Chemistry. 64:5404-5428
The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase (hDHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from pharma as a possible AML therapeutic target. We recently discovered compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281c81addc6474b683c17e342be6dc2c
https://doi.org/10.1021/acs.jmedchem.0c01549
https://doi.org/10.1021/acs.jmedchem.0c01549
Autor:
Elisabetta Muntoni, Katia Martina, Elisabetta Marini, Marta Giorgis, Loretta Lazzarato, Iris Chiara Salaroglio, Chiara Riganti, Michele Lanotte, Luigi Battaglia
Publikováno v:
Pharmaceutics, Vol 11, Iss 2, p 65 (2019)
Glioblastoma is the most common and invasive primary tumor of the central nervous system and normally has a negative prognosis. Biodistribution in healthy animal models is an important preliminary study aimed at investigating the efficacy of chemothe
Externí odkaz:
https://doaj.org/article/3ce694f3c533405db4d88b4341cada89
Autor:
Mohammad Houshmand, Nicoletta Vitale, Francesca Orso, Alessandro Cignetti, Ivan Molineris, Valentina Gaidano, Stefano Sainas, Marta Giorgis, Donatella Boschi, Carmen Fava, Alessandra Iurlo, Elisabetta Abruzzese, Massimo Breccia, Olga Mulas, Giovanni Caocci, Fausto Castagnetti, Daniela Taverna, Fabrizio Pane, Marco Lolli, Paola Circosta, Giuseppe Saglio
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:S288-S289
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0382bd9ffccb51dd075de5a1f0fc9419
https://doi.org/10.1016/s2152-2650(22)01366-0
https://doi.org/10.1016/s2152-2650(22)01366-0