The effect of gD-derived peptides on T cell immune response mediated by BTLA-HVEM protein complex in melanoma patients

Autor: Karolina Wojciechowicz, Katarzyna Kuncewicz, Jacek Rutkowski, Jacek Jassem, Anna Wardowska, Marta Spodzieja

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionThe effector function of T cells is regulated via immune checkpoints, activating or inhibiting the immune response. The BTLA-HVEM complex, the inhibitory immune checkpoint, may act as one of the tumor immune escape mechanisms. Therefore,

Externí odkaz: https://doaj.org/article/95f6d24fdd1141448d7f04dd8fa0a2e0

Exploring the inhibitory potential of in silico-designed small peptides on Helicobacter pylori Hp0231 (DsbK), a periplasmic oxidoreductase involved in disulfide bond formation

Autor: Paula Roszczenko-Jasińska, Artur Giełdoń, Dominika Mazur, Marta Spodzieja, Maciej Plichta, Cezary Czaplewski, Wojciech Bal, Elzbieta K. Jagusztyn-Krynicka, Dariusz Bartosik

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2024)

Introduction:Helicobacter pylori is a bacterium that colonizes the gastric epithelium, which affects millions of people worldwide. H. pylori infection can lead to various gastrointestinal diseases, including gastric adenocarcinoma and mucosa-associat

Externí odkaz: https://doaj.org/article/1b628f976fc34003815c9fe63d50ded5

Design, synthesis and biological evaluation of PD-1 derived peptides as inhibitors of PD-1/PD-L1 complex formation for cancer therapy

Autor: Magdalena Bojko, Katarzyna Węgrzyn, Emilia Sikorska, Mikołaj Kocikowski, Maciej Parys, Claire Battin, Peter Steinberger, Małgorzata M. Kogut, Michał Winnicki, Adam K. Sieradzan, Marta Spodzieja, Sylwia Rodziewicz-Motowidło

Publikováno v: Bojko, M, Węgrzyn, K, Sikorska, E, Kocikowski, M, Parys, M, Battin, C, Steinberger, P, Kogut, M M, Winnicki, M, Sieradzan, A K, Spodzieja, M & Rodziewicz-Motowidło, S 2022, ' Design, synthesis and biological evaluation of PD-1 derived peptides as inhibitors of PD-1/PD-L1 complex formation for cancer therapy ', Bioorganic Chemistry, vol. 128, 106047, pp. 1-15 . https://doi.org/10.1016/j.bioorg.2022.106047

Over the past few years, many molecules such as monoclonal antibodies, affibodies, nanobodies, and small compounds have been designed and tested as inhibitors of PD-1/PD-L1 complex formation. Some of them have been successfully implemented into clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9790c9134f309a5f8bd988d48eb72b6f
https://doi.org/10.1016/j.bioorg.2022.106047

Hyphenated Mass Spectrometry Techniques in the Diagnosis of Amyloidosis

Autor: Marta Spodzieja, Sylwia Rodziewicz-Motowidło, Aneta Szymańska

Publikováno v: Current Medicinal Chemistry. 26:104-120

Amyloidoses are a group of diseases caused by the extracellular deposition of proteins forming amyloid fibrils. The amyloidosis is classified according to the main protein or peptide that constitutes the amyloid fibrils. The most effective methods fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17fce32995a21964d28403abe71c7da
https://doi.org/10.2174/0929867324666171003113019

The role of the BTLA-HVEM complex in the pathogenesis of autoimmune diseases

Autor: Karolina Wojciechowicz, Marta Spodzieja, Katarzyna A. Lisowska, Anna Wardowska

Publikováno v: Cellular Immunology. 376:104532

Autoimmune diseases constitute a heterogeneous group of disorders with one common feature - the loss of immune tolerance towards autoantigens. Due to the complexity of the pathogenesis of these diseases, there are still many open questions regarding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9565a9523e080100b8e4d0d68e8f4941
https://doi.org/10.1016/j.cellimm.2022.104532