Výsledky vyhledávání

Akademický článek

Exploring the RC-106 Chemical Space: Design and Synthesis of Novel (E)-1-(3-Arylbut-2-en-1-yl)-4-(Substituted) Piperazine Derivatives as Potential Anticancer Agents

Autor: Roberta Listro, Silvia Stotani, Giacomo Rossino, Marta Rui, Alessio Malacrida, Guido Cavaletti, Michela Cortesi, Chiara Arienti, Anna Tesei, Daniela Rossi, Marcello Di Giacomo, Mariarosaria Miloso, Simona Collina

Publikováno v: Frontiers in Chemistry, Vol 8 (2020)

Despite the fact that significant advances in treatment of common cancers have been achieved over the years, orphan tumors still represent an important unmet medical need. Due to their complex multifactorial origin and limited number of cases, such p

Externí odkaz: https://doaj.org/article/a8fde02e354a4f4283e5bee834b259fd

Zobrazit plný text záznamu

Akademický článek

Anti-tumor Efficacy Assessment of the Sigma Receptor Pan Modulator RC-106. A Promising Therapeutic Tool for Pancreatic Cancer

Autor: Anna Tesei, Michela Cortesi, Sara Pignatta, Chiara Arienti, Giulio Massimo Dondio, Chiara Bigogno, Alessio Malacrida, Mariarosaria Miloso, Cristina Meregalli, Alessia Chiorazzi, Valentina Carozzi, Guido Cavaletti, Marta Rui, Annamaria Marra, Daniela Rossi, Simona Collina

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Introduction: Pancreatic cancer (PC) is one of the most lethal tumor worldwide, with no prognosis improvement over the past 20-years. The silent progressive nature of this neoplasia hampers the early diagnosis, and the surgical resection of the tumor

Externí odkaz: https://doaj.org/article/e889e8abc8fa45a8a8c6a8d1b9b52103

Zobrazit plný text záznamu

Akademický článek

Sigma Receptors as Endoplasmic Reticulum Stress 'Gatekeepers' and their Modulators as Emerging New Weapons in the Fight Against Cancer

Autor: Anna Tesei, Michela Cortesi, Alice Zamagni, Chiara Arienti, Sara Pignatta, Michele Zanoni, Mayra Paolillo, Daniela Curti, Marta Rui, Daniela Rossi, Simona Collina

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Despite the interest aroused by sigma receptors (SRs) in the area of oncology, their role in tumor biology remains enigmatic. The predominant subcellular localization and main site of activity of SRs are the endoplasmic reticulum (ER). Current litera

Externí odkaz: https://doaj.org/article/b7d017a0719848b791ff3bb92d712d7b

Zobrazit plný text záznamu

The epidemiology and management of ameloblastomas: A European multicenter study

Publikováno v: Boffano, P, Cavarra, F, Tricarico, G, Masu, L, Brucoli, M, Ruslin, M, Forouzanfar, T, Ridwan-Pramana, A, Rodríguez-Santamarta, T, Rui Ranz, M, de Vicente, J C, Starch-Jensen, T, Pechalova, P, Pavlov, N, Doykova, I, Konstantinovic, V S, Jelovac, D, Barrabé, A, Louvrier, A, Meyer, C, Tamme, T, Andrianov, A, Dovšak, T, Birk, A, Hresko, A, Chepurnyi, Y, Kopchak, A, Snäll, J, Hagström, J, Rasmusson, L & Rocchetti, V 2021, ' The epidemiology and management of ameloblastomas : A European multicenter study ', Journal of Cranio-Maxillofacial Surgery, vol. 49, no. 12, pp. 1107-1112 . https://doi.org/10.1016/j.jcms.2021.09.007
Journal of Cranio-Maxillofacial Surgery, 49(12), 1107-1112. Churchill Livingstone

The present study aimed at assessing the epidemiology including demographic variables, diagnostic features, and management of ameloblastomas at several European departments of maxillofacial and oral surgery. The following data were recorded for each

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bfce4a62766af84376c9edc673473fc
https://doi.org/10.1016/j.jcms.2021.09.007

Zobrazit plný text záznamu

Bitopic Sigma 1 Receptor Modulators to Shed Light on Molecular Mechanisms Underpinning Ligand Binding and Receptor Oligomerization

Autor: Simona Collina, Dirk Schepmann, Giacomo Rossino, Pasquale Linciano, Mariela González-Avendaño, Julio Caballero, Bernhard Wünsch, Daniela Curti, Ariela Vergara-Jaque, Marco Peviani, Daniela Rossi, Massimo Boiocchi, Marta Rui, Elena Poggio

Publikováno v: Journal of Medicinal Chemistry. 64:14997-15016

The sigma 1 receptor (S1R) is an enigmatic ligand-operated chaperone involved in many important biological processes, and its functions are not fully understood yet. Herein, we developed a novel series of bitopic S1R ligands as versatile tools to inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a35e9018b18fd9aa96b2e1611c1d54
https://doi.org/10.1021/acs.jmedchem.1c00886

Zobrazit plný text záznamu

Akademický článek

Dual-Functioning Scaffolds for the Treatment of Spinal Cord Injury: Alginate Nanofibers Loaded with the Sigma 1 Receptor (S1R) Agonist RC-33 in Chitosan Films

Autor: Barbara Vigani, Silvia Rossi, Giuseppina Sandri, Maria Cristina Bonferoni, Marta Rui, Simona Collina, Francesca Fagiani, Cristina Lanni, Franca Ferrari

Publikováno v: Marine Drugs, Vol 18, Iss 1, p 21 (2019)

The present work proposed a novel therapeutic platform with both neuroprotective and neuroregenerative potential to be used in the treatment of spinal cord injury (SCI). A dual-functioning scaffold for the delivery of the neuroprotective S1R agonist,

Externí odkaz: https://doaj.org/article/f2ad257971bd46f28e0a3729b1a62e7e

Zobrazit plný text záznamu

Akademický článek

Chiral Resolution of a New Agent against Memory Impairment Connected to Neurodegenerative Diseases

Autor: Valeria Cavalloro, Marta Rui, Giacomo Rossino, Daniela Rossi, Federica Rapetti, Chiara Brullo, Olga Bruno, Simona Collina

Publikováno v: Proceedings, Vol 22, Iss 1, p 15 (2019)

Nowadays, the incidence of neurodegenerative diseases is increasing, and these disorders will become one of the main challenges for medicine and public health in future years. Particularly, memory loss characterizes many neurodegenerative pathologies

Externí odkaz: https://doaj.org/article/c57217bcf2314546974088bf34cb8d3e

Zobrazit plný text záznamu

Akademický článek

Novel Dual Ligands Targeting Sigma1 Receptor and Acetylcholinesterase Endowed with Antioxidant Properties

Autor: Giacomo Rossino, Marta Rui, Dirk Schepmann, Bernard Wünsch, Stefania Monteleone, Klaus Liedl, Vittorio Pace, Daniela Rossi, Simona Collina

Publikováno v: Proceedings, Vol 22, Iss 1, p 49 (2019)

Neurodegenerative disorders represent one of the main therapeutic challenges of our time. [...]

Externí odkaz: https://doaj.org/article/956d204eaf4747a3bae0b8507d13e98d

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání