Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Marta, Mir"'
Autor:
Laura Vidal, Miriam Andrés, Marta Mir, Pilar Forns, Sara Sevilla, Bernat Vidal, Estrella Lozoya, Cristina Esteve, Mónica Bravo, Manel Ferrer, Paul R. Eastwood, Richard S. Roberts, Jordi Castro, Elena Gómez, Marta Calbet, Pere Vilaseca, Jacob González, Imma Moreno, Silvia Petit, J. A. Alonso, Maria Antonia Buil
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5127-5133
The correct positioning and orientation of an hydrogen bond acceptor (HBA) in the tail portion of the biaryl series of CRTh2 antagonists is a requirement for long receptor residence time. The HBA in combination with a small steric substituent in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b468e1247865bc00ad5b1e097179b4b4
https://doi.org/10.1016/j.bmcl.2014.08.028
https://doi.org/10.1016/j.bmcl.2014.08.028
Autor:
Cristina Esteve, Jacob González, Pere Vilaseca, Marta Calbet, Imma Moreno, Marta Mir, Richard S. Roberts, Silvia Petit, Elena Gómez, Mónica Bravo, Miriam Zanuy, J. A. Alonso, Manel Ferrer, Sara Sevilla, Laura Vidal, Peter Eichhorn, Miriam Andrés, Paul R. Eastwood, Bernat Vidal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5123-5126
Extensive structure–activity relationship (SAR) and structure–kinetic relationship (SKR) studies in the bicyclic heteroaromatic series of CRTh2 antagonists led to the identification of several molecules that possessed both excellent binding and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25504733d7dc10ba602aaeb837967766
https://doi.org/10.1016/j.bmcl.2014.08.029
https://doi.org/10.1016/j.bmcl.2014.08.029
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists
Autor:
Gema Tarrasón, Nuria Godessart, Marta Mir, Clara Armengol, Mònica Córdoba, Dolors Vilella, Daniel Casals, Manel López, Victor Segarra, Teresa Doménech, Imma Moreno, M Sabate, Nuria Aguilar, Pedro M. Grima, María Domínguez, Laia Esteban
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7672-7676
Amido-1,3,4-thiadiazoles have been identified as a novel structural class of potent and selective sphingosine-1-phosphate receptor subtype 1 agonists. Starting from a micromolar HTS hit with the help of an in-house homology model, robust structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::267ca19860dca563219d7e83fee9d6af
https://doi.org/10.1016/j.bmcl.2012.09.110
https://doi.org/10.1016/j.bmcl.2012.09.110
Autor:
Montserrat Miralpeix, Manel López, Marcos Castillo, Montse Erra, Adelina Orellana, Bernat Vidal, Marta Mir, Pilar Forns, Isabel Ramis, M. I. Maldonado, Cristina Carreño
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5419-5423
A novel class of potent Syk inhibitors has been developed from rational design. Highly potent aminopyridine derivatives bearing a 4-trifluoromethyl-2-pyridyl motif and represented by compound 13b IC50: 0.6 nM were identified. Substitution by a 2-pyra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e90581305020a2c193ef25ff0d38fc7
https://doi.org/10.1016/j.bmcl.2012.07.045
https://doi.org/10.1016/j.bmcl.2012.07.045
Autor:
Paul R. Eastwood, Jacob González, Cristina Balagué, Elena Gómez, Francisco Caturla, Josep Aiguadé, Victor G. Matassa, Nuria Aguilar, María Domínguez, Marta Mir, Adelina Orellana
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6253-6257
Crystallographic structural information was used in the design and synthesis of a number of bioisosteric derivatives to replace the amide moiety in a lead series of p38α inhibitors which showed general hydrolytic instability in human liver preparati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddede93fe6fed0f1a68abe28c418232
https://doi.org/10.1016/j.bmcl.2011.09.006
https://doi.org/10.1016/j.bmcl.2011.09.006
Autor:
Pere Vilaseca, Elena Gómez, Mónica Bravo, Jacob González, Jordi Castro, Miriam Andrés, Bernat Vidal, Richard S. Roberts, Marta Mir, Silvia Petit, Maria Antonia Buil, Miriam Zanuy, Cristina Esteve, Marta Calbet, J. A. Alonso, Laura Vidal, Peter Eichhorn, Paul R. Eastwood
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(21)
A knowledge-based design strategy led to the discovery of several new series of potent and orally bioavailable CRTh2 antagonists where a bicyclic heteroaromatic ring serves as the central core. Structure–kinetic relationships (SKR) opened up the po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef028d788ad740c5847971f16633f751
https://pubmed.ncbi.nlm.nih.gov/25437504
https://pubmed.ncbi.nlm.nih.gov/25437504
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P₁ direct agonists
Autor:
Nuria, Aguilar, Marta, Mir, Pedro M, Grima, Manel, López, Victor, Segarra, Laia, Esteban, Imma, Moreno, Nuria, Godessart, Gema, Tarrasón, Teresa, Domenech, Dolors, Vilella, Clara, Armengol, Mònica, Córdoba, Mar, Sabaté, Daniel, Casals, Maria, Domínguez
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(24)
Amido-1,3,4-thiadiazoles have been identified as a novel structural class of potent and selective sphingosine-1-phosphate receptor subtype 1 agonists. Starting from a micromolar HTS hit with the help of an in-house homology model, robust structural-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b6d390fb1e124b77845c2f17ba30813
https://pubmed.ncbi.nlm.nih.gov/23141913
https://pubmed.ncbi.nlm.nih.gov/23141913