Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Marta, Melis"'
Autor:
Marta Melis, Rebecca Marino, Jianmin Tian, Carla Johnson, Rahil Sethi, Michael Oertel, Ira J. Fox, Joseph Locker
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 3, Pp 453-479 (2024)
Background & Aims: HNF4α, a master regulator of liver development and the mature hepatocyte phenotype, is down-regulated in chronic and inflammatory liver disease. We used contemporary transcriptomics and epigenomics to study the cause and effects o
Externí odkaz:
https://doaj.org/article/270e6dc5cdb04a1fb26e7c7fe9fb3567
Autor:
Marta Melis, Steven E. Trasino, Xiao-Han Tang, Andrew Rappa, Tuo Zhang, Lihui Qin, Lorraine J. Gudas
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12035 (2023)
In alcohol-associated liver disease (ALD), hepatic reductions in vitamin A and perturbations in vitamin A metabolism are common. However, the roles that the vitamin A receptors, termed retinoic acid receptors (RARs), may have in preventing the pathop
Externí odkaz:
https://doaj.org/article/214744a9cdbe42a398988bf3d7e684b6
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Alcohol liver disease (ALD) is a major cause of liver-related mortality globally, yet there remains an unmet demand for approved ALD drugs. The pathogenesis of ALD involves perturbations to the intestinal barrier and subsequent translocation of bacte
Externí odkaz:
https://doaj.org/article/73a54e73b1fc4cbbb3c0041cc3b0a358
Publikováno v:
Nutrients, Vol 14, Iss 7, p 1456 (2022)
Vitamin A (VA), all-trans-retinol (ROL), and its analogs are collectively called retinoids. Acting through the retinoic acid receptors RARα, RARβ, and RARγ, all-trans-retinoic acid, an active metabolite of VA, is a potent regulator of numerous bio
Externí odkaz:
https://doaj.org/article/0c9cd29ffa7a4e8aa8f0718110585f57
Autor:
Sarah Vascellari, Vanessa Palmas, Marta Melis, Silvia Pisanu, Roberto Cusano, Paolo Uva, Daniela Perra, Veronica Madau, Marianna Sarchioto, Valentina Oppo, Nicola Simola, Micaela Morelli, Maria Laura Santoru, Luigi Atzori, Maurizio Melis, Giovanni Cossu, Aldo Manzin
Publikováno v:
mSystems, Vol 5, Iss 5 (2020)
ABSTRACT Parkinson’s disease is a neurodegenerative disorder characterized by the accumulation of intracellular aggregates of misfolded alpha-synuclein along the cerebral axis. Several studies report the association between intestinal dysbiosis and
Externí odkaz:
https://doaj.org/article/809869bcae4e4aafac202dd23e421b0b
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Among non-motor manifestations of Parkinson's Disease (PD), peripheral, sensory symptoms are particularly relevant. Smell dysfunction starts very early and frequently precedes the PD motor symptoms by years (being often a cue to the diagnosis). Moreo
Externí odkaz:
https://doaj.org/article/f0271aaa39ca4215bdc105ab47a6f2ee
Autor:
Marta Melis, Xiao-Han Tang, Steven E Trasino, Viral M Patel, Daniel J Stummer, Jose Jessurun, Lorraine J Gudas
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211071 (2019)
The roles of retinoids in nonalcoholic fatty liver disease (NAFLD) remain unclear and a better understanding may lead to therapies that prevent or limit NAFLD progression. We examined the actions of retinoic acid receptor (RAR) agonists- AM80 for RAR
Externí odkaz:
https://doaj.org/article/183e0135b1c1443d89683f61a7f267f1
Autor:
Patrizia Farci, David E. Kleiner, Sugantha Govindarajan, Fausto Zamboni, Ian N. Moore, Kevin W. Bock, Michael R. Emmert-Buck, Jeffrey Hanson, Jaime Rodriguez-Canales, Stephanie Montenegro, Marta Melis, Ashley Tice, Ronald E. Engle, Giacomo Diaz
Synopsis of the 20 top-scored pathways associated with WLT-unique genes identified in the three tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb1e889ecb4bfa8d458eacface4c9d5
https://doi.org/10.1158/1541-7786.22515784.v1
https://doi.org/10.1158/1541-7786.22515784.v1
Autor:
Sarah Vascellari, Marta Melis, Vanessa Palmas, Silvia Pisanu, Alessandra Serra, Daniela Perra, Maria Laura Santoru, Valentina Oppo, Roberto Cusano, Paolo Uva, Luigi Atzori, Micaela Morelli, Giovanni Cossu, Aldo Manzin
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 144 (2021)
Parkinson’s disease (PD) is a clinically heterogenic disorder characterized by distinct clinical entities. Most studies on motor deficits dichotomize PD into tremor dominant (TD) or non-tremor dominant (non-TD) with akinetic-rigid features (AR). Di
Externí odkaz:
https://doaj.org/article/27c8cac0297b445989eb71c5ebf088cc
Autor:
Rosario Vasta, Gianluca Floris, Sabino Dagostino, Pier Francesco Cappai, Giuseppe Piga, Maurizio Melis, Giovanni Defazio, Antonella Muroni, Carlo Conti, Vincenzo Pierri, Francesca Bruder, Tommaso Ercoli, Cristina Manieli, Valerio Melas, Marta Melis, Alberto Maleci
Publikováno v:
Neurological Sciences. 43:419-425
PURPOSE To study for the first time the incidence of adult-onset CNS tumors in Southern Sardinia, Italy. METHODS Clinical records of patients > 18 years old who were diagnosed with primary CNS tumors during 2016-2019 in the study area were reviewed.