Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Marta, Melé"'
Autor:
Drew Neavin, Anne Senabouth, Himanshi Arora, Jimmy Tsz Hang Lee, Aida Ripoll-Cladellas, sc-eQTLGen Consortium, Lude Franke, Shyam Prabhakar, Chun Jimmie Ye, Davis J. McCarthy, Marta Melé, Martin Hemberg, Joseph E. Powell
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-24 (2024)
Abstract Recent innovations in single-cell RNA-sequencing (scRNA-seq) provide the technology to investigate biological questions at cellular resolution. Pooling cells from multiple individuals has become a common strategy, and droplets can subsequent
Externí odkaz:
https://doaj.org/article/7209fadf8e984cfb87325f01f83f0d88
Autor:
Sergio Andreu-Sánchez, Aida Ripoll-Cladellas, Anna Culinscaia, Ozlem Bulut, Arno R. Bourgonje, Mihai G. Netea, Peter Lansdorp, Geraldine Aubert, Marc Jan Bonder, Lude Franke, Thomas Vogl, Monique G.P. van der Wijst, Marta Melé, Debbie Van Baarle, Jingyuan Fu, Alexandra Zhernakova
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109981- (2024)
Summary: Encounters with pathogens and other molecules can imprint long-lasting effects on our immune system, influencing future physiological outcomes. Given the wide range of microbes to which humans are exposed, their collective impact on health i
Externí odkaz:
https://doaj.org/article/a625eed26ff74ff68e49a04b0978d288
Autor:
Luisa Santus, Maria Sopena-Rios, Raquel García-Pérez, Aaron E. Lin, Gordon C. Adams, Kayla G. Barnes, Katherine J. Siddle, Shirlee Wohl, Ferran Reverter, John L. Rinn, Richard S. Bennett, Lisa E. Hensley, Pardis C. Sabeti, Marta Melé
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Long non-coding RNAs (lncRNAs) are involved in numerous biological processes and are pivotal mediators of the immune response, yet little is known about their properties at the single-cell level. Here, we generate a multi-tissue bulk RNAseq
Externí odkaz:
https://doaj.org/article/5370a6f7e4c54340b26405e7cf365b14
Autor:
Sergio Andreu-Sánchez, Geraldine Aubert, Aida Ripoll-Cladellas, Sandra Henkelman, Daria V. Zhernakova, Trishla Sinha, Alexander Kurilshikov, Maria Carmen Cenit, Marc Jan Bonder, Lude Franke, Cisca Wijmenga, Jingyuan Fu, Monique G. P. van der Wijst, Marta Melé, Peter Lansdorp, Alexandra Zhernakova
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Deep molecular and phenotypic data highlights the links of human telomere lengths from six different blood cells with genetics, parental phenotypes mediated by epigenetic signals and expression changes at the single cell level.
Externí odkaz:
https://doaj.org/article/0a00c1e07f114ae59b1c44d8c5c72806
Autor:
Raquel García-Pérez, Jose Miguel Ramirez, Aida Ripoll-Cladellas, Ruben Chazarra-Gil, Winona Oliveros, Oleksandra Soldatkina, Mattia Bosio, Paul Joris Rognon, Salvador Capella-Gutierrez, Miquel Calvo, Ferran Reverter, Roderic Guigó, François Aguet, Pedro G. Ferreira, Kristin G. Ardlie, Marta Melé
Publikováno v:
Cell Genomics, Vol 3, Iss 1, Pp 100244- (2023)
Summary: Understanding the consequences of individual transcriptome variation is fundamental to deciphering human biology and disease. We implement a statistical framework to quantify the contributions of 21 individual traits as drivers of gene expre
Externí odkaz:
https://doaj.org/article/d4d8673d5dce46658f913ea2f6071d9a
Autor:
Robert Lesurf, Abdelrahman Said, Oyediran Akinrinade, Jeroen Breckpot, Kathleen Delfosse, Ting Liu, Roderick Yao, Gabrielle Persad, Fintan McKenna, Ramil R. Noche, Winona Oliveros, Kaia Mattioli, Shreya Shah, Anastasia Miron, Qian Yang, Guoliang Meng, Michelle Chan Seng Yue, Wilson W. L. Sung, Bhooma Thiruvahindrapuram, Jane Lougheed, Erwin Oechslin, Tapas Mondal, Lynn Bergin, John Smythe, Shashank Jayappa, Vinay J. Rao, Jayaprakash Shenthar, Perundurai S. Dhandapany, Christopher Semsarian, Robert G. Weintraub, Richard D. Bagnall, Jodie Ingles, Genomics England Research Consortium, Marta Melé, Philipp G. Maass, James Ellis, Stephen W. Scherer, Seema Mital
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-17 (2022)
Abstract Cardiomyopathy (CMP) is a heritable disorder. Over 50% of cases are gene-elusive on clinical gene panel testing. The contribution of variants in non-coding DNA elements that result in cryptic splicing and regulate gene expression has not bee
Externí odkaz:
https://doaj.org/article/98efc3d1863c49afbe226a84a5eb5c6f
Autor:
Kaia Mattioli, Winona Oliveros, Chiara Gerhardinger, Daniel Andergassen, Philipp G. Maass, John L. Rinn, Marta Melé
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-22 (2020)
Abstract Background Gene expression differences between species are driven by both cis and trans effects. Whereas cis effects are caused by genetic variants located on the same DNA molecule as the target gene, trans effects are due to genetic variant
Externí odkaz:
https://doaj.org/article/b5287a60730a42c69cdd4a46e35f6885
Autor:
Tian V. Tian, Teresa Macarulla, Sandra Peiró, Josep Tabernero, Joaquín Arribas, Violeta Serra, Marta Melé, Ana Vivancos, Paolo G. Nuciforo, Josep M. Miquel, Óscar J. Pozo, Francis J. Giles, Noemí Haro, Cristina Bernadó-Morales, Enrique J. Arenas, Marta Escorihuela, Carmen Escudero-Iriarte, Carles Fabregat-Franco, Florian Castet, Mariana Yáñez-Bartolomé, Jessica Querol, Joan Frigola, Cindy Neuzillet, Anthony Turpin, Maria Vila-Casadesús, Cristina Molina, Alba Llop-Guevara, Núria Lupión-Garcia, Winona Oliveros, Helena Verdaguer, Queralt Serra-Camprubí
Information of patients underwent the biopsy procedures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c01603d143aabc99513a7d81963a854
https://doi.org/10.1158/1078-0432.22488986.v1
https://doi.org/10.1158/1078-0432.22488986.v1
Autor:
Tian V. Tian, Teresa Macarulla, Sandra Peiró, Josep Tabernero, Joaquín Arribas, Violeta Serra, Marta Melé, Ana Vivancos, Paolo G. Nuciforo, Josep M. Miquel, Óscar J. Pozo, Francis J. Giles, Noemí Haro, Cristina Bernadó-Morales, Enrique J. Arenas, Marta Escorihuela, Carmen Escudero-Iriarte, Carles Fabregat-Franco, Florian Castet, Mariana Yáñez-Bartolomé, Jessica Querol, Joan Frigola, Cindy Neuzillet, Anthony Turpin, Maria Vila-Casadesús, Cristina Molina, Alba Llop-Guevara, Núria Lupión-Garcia, Winona Oliveros, Helena Verdaguer, Queralt Serra-Camprubí
Evaluation of RAD51 scores in CCA_PDXs and CCA patients. (A) RAD51 scores of CCA_PDXs and their matched originating biopsy samples. (B) RAD51 scores evaluated in PDX85 (IDH1mut) treated as for Figure 4C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a82f369826c036fa8fd57e381e4cec
https://doi.org/10.1158/1078-0432.22488992.v1
https://doi.org/10.1158/1078-0432.22488992.v1
Autor:
Tian V. Tian, Teresa Macarulla, Sandra Peiró, Josep Tabernero, Joaquín Arribas, Violeta Serra, Marta Melé, Ana Vivancos, Paolo G. Nuciforo, Josep M. Miquel, Óscar J. Pozo, Francis J. Giles, Noemí Haro, Cristina Bernadó-Morales, Enrique J. Arenas, Marta Escorihuela, Carmen Escudero-Iriarte, Carles Fabregat-Franco, Florian Castet, Mariana Yáñez-Bartolomé, Jessica Querol, Joan Frigola, Cindy Neuzillet, Anthony Turpin, Maria Vila-Casadesús, Cristina Molina, Alba Llop-Guevara, Núria Lupión-Garcia, Winona Oliveros, Helena Verdaguer, Queralt Serra-Camprubí
Purpose:Cholangiocarcinoma (CCA) is usually diagnosed at advanced stages, with limited therapeutic options. Preclinical models focused on unresectable metastatic CCA are necessary to develop rational treatments. Pathogenic mutations in IDH1/2, ARID1A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffad5473b6ac95e115576bc8c4bb844
https://doi.org/10.1158/1078-0432.c.6532853.v1
https://doi.org/10.1158/1078-0432.c.6532853.v1