Testosterone is an endogenous regulator of BAFF and splenic B cell number

Autor: Anna S. Wilhelmson, Marta Lantero Rodriguez, Alexandra Stubelius, Per Fogelstrand, Inger Johansson, Matthew B. Buechler, Steve Lianoglou, Varun N. Kapoor, Maria E. Johansson, Johan B. Fagman, Amanda Duhlin, Prabhanshu Tripathi, Alessandro Camponeschi, Bo T. Porse, Antonius G. Rolink, Hans Nissbrandt, Shannon J. Turley, Hans Carlsten, Inga-Lill Mårtensson, Mikael C. I. Karlsson, Åsa Tivesten

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Testosterone deficiency is associated with autoimmunity and increased B cell numbers, but the underlying mechanism is unclear. Here the authors show that testosterone may modulate the production of B cell survival factor BAFF by fibroblastic reticula

Externí odkaz: https://doaj.org/article/d1f804563c204b959332c0cb6ac7f78d

Testosterone reduces metabolic brown fat activity in male mice

Autor: Marta Lantero Rodriguez, Vilborg Palsdottir, Marcus Henricsson, Elin Svedlund Eriksson, Sander Kooijman, Patrick C.N. Rensen, Jan Kroon, Malin Levin, Inger Johansson, Maaike Schilperoort, John-Olov Jansson, Claes Ohlsson, Åsa Tivesten, Jan Borén, Mia Ericson

Publikováno v: Journal of Endocrinology
Journal of Endocrinology, 251(1), 83-96. BIOSCIENTIFICA LTD

Brown adipose tissue (BAT) burns substantial amounts of mainly lipids to produce heat. Some studies indicate that BAT activity and core body temperature are lower in males than females. Here we investigated the role of testosterone and its receptor (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779b27c355278790b4c92fcc5a124d10
https://pubmed.ncbi.nlm.nih.gov/34370693

Testosterone is an endogenous regulator of BAFF and splenic B cell number

Autor: Hans Carlsten, Amanda Duhlin, Prabhanshu Tripathi, Alessandro Camponeschi, Mikael C. I. Karlsson, Maria E. Johansson, Steve Lianoglou, Per Fogelstrand, Alexandra Stubelius, Åsa Tivesten, Inger Johansson, Varun N. Kapoor, Johan Bourghardt Fagman, Anna S. Wilhelmson, Hans Nissbrandt, Matthew B. Buechler, Shannon J. Turley, Bo T. Porse, Inga-Lill Mårtensson, Antonius G. Rolink, Marta Lantero Rodriguez

Publikováno v: Nature Communications
Wilhelmson, A S, Lantero Rodriguez, M, Stubelius, A, Fogelstrand, P, Johansson, I, Buechler, M B, Lianoglou, S, Kapoor, V N, Johansson, M E, Fagman, J B, Duhlin, A, Tripathi, P, Camponeschi, A, Porse, B T, Rolink, A G, Nissbrandt, H, Turley, S J, Carlsten, H, Mårtensson, I-L, Karlsson, M C I & Tivesten, Å 2018, ' Testosterone is an endogenous regulator of BAFF and splenic B cell number ', Nature Communications, vol. 9, 2067, pp. 1-13 . https://doi.org/10.1038/s41467-018-04408-0
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Testosterone deficiency in men is associated with increased risk for autoimmunity and increased B cell numbers through unknown mechanisms. Here we show that testosterone regulates the cytokine BAFF, an essential survival factor for B cells. Male mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c447a10aeadf117544609da6f5bd04
http://europepmc.org/articles/PMC5970247