Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

Autor: Jean-Philippe Brouland, Cristina Cudalbu, Lijing Xin, Andreas F. Hottinger, Roy Thomas Daniel, Monika E. Hegi, Pierre Bady, Marta Lai, Olga Gusyatiner, Mario Lepore, Marie-France Hamou

Publikováno v: Acta neuropathologica communications, vol. 9, no. 1, pp. 133
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-16 (2021)
Acta Neuropathologica Communications
BioRxiv

The invasive behavior of glioblastoma, the most aggressive primary brain tumor, is considered highly relevant for tumor recurrence. However, the invasion zone is difficult to visualize by Magnetic Resonance Imaging (MRI) and is protected by the blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7278226f5c798527e12857fb894c162
https://serval.unil.ch/notice/serval:BIB_CB8B36AE633E

OTME-13. Integration of metabolic and transcriptional signatures of glioblastoma invasion reveals extracellular matrix reorganization and vasculature remodeling

Autor: Jean-Philippe Brouland, Marie-France Hamou, Monika E. Hegi, Pierre Bady, Cristina Cudalbu, Roy Thomas Daniel, Marta Lai, Andreas F. Hottinger, Lijing Xin, Olga Gusyatiner, Mario Lepore

Publikováno v: Neuro-oncology Advances

Background The invasive behavior of glioblastoma is considered highly relevant for recurrence. However, the invasion zone is difficult to visualize, typically lies outside the resected and irradiated area, and is protected by the blood brain barrier,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b29379da125d309645ceca6d89c495
https://doi.org/10.1093/noajnl/vdab070.064

Progress towards in vivo brain 13C-MRS in mice: Metabolic flux analysis in small tissue volumes

Autor: Marta Lai, Bernard Lanz, Rolf Gruetter

Publikováno v: Analytical Biochemistry. 529:229-244

The combination of dynamic 13C MRS data under infusion of 13C-labelled substrates and compartmental models of cerebral metabolism enabled in vivo measurement of metabolic fluxes with a quantitative and distinct determination of cellular-specific acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47ba60c9a6064bfd431e62df8428598b
https://doi.org/10.1016/j.ab.2017.01.019

In vivo characterization of brain metabolism by

Autor: Marta, Lai, Irene, Vassallo, Bernard, Lanz, Carole, Poitry-Yamate, Marie-France, Hamou, Cristina, Cudalbu, Rolf, Gruetter, Monika E, Hegi

Publikováno v: International journal of cancer. 143(1)

Glioblastoma are notorious for their highly invasive growth, diffusely infiltrating adjacent brain structures that precludes complete resection, and is a major obstacle for cure. To characterize this "invisible" tumor part, we designed a high resolut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12ada77faeb6db1dbf9715b8b4c7f873
https://pubmed.ncbi.nlm.nih.gov/29417580

A Monte-Carlo based model of the AX-PET demonstrator and its experimental validation

Autor: Josep F. Oliver, P. Weilhammer, Matthieu Heller, Uygar Tuna, Steinar Stapnes, A. Rudge, Thomas Schneider, Viviana Fanti, Marta Lai, Ulla Ruotsalainen, E. Bolle, Jacques Séguinot, John E. Gillam, P. Solevi, Magdalena Rafecas, Werner Lustermann, C. Joram, R. De Leo, E. Chesi, Felicitas Pauss, C. Casella, E. Nappi, Günther Dissertori, D. Schinzel

Publikováno v: Physics in Medicine and Biology. 58:5495-5510

AX-PET is a novel PET detector based on axially oriented crystals and orthogonal wavelength shifter (WLS) strips, both individually read out by silicon photo-multipliers. Its design decouples sensitivity and spatial resolution, by reducing the parall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ee23e2975a45386f3723a16da0f6a8
https://doi.org/10.1088/0031-9155/58/16/5495