Zobrazeno 1 - 10
of 502
pro vyhledávání: '"Marta, Cascante"'
Autor:
Joan Serrano-Marín, Silvia Marin, David Bernal-Casas, Alejandro Lillo, Marc González-Subías, Gemma Navarro, Marta Cascante, Juan Sánchez-Navés, Rafael Franco
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Background The lack of accessible and informative biomarkers results in a delayed diagnosis of Parkinson’s disease (PD), whose symptoms appear when a significant number of dopaminergic neurons have already disappeared. The retina, a histor
Externí odkaz:
https://doaj.org/article/769e14cb8b1047628b6f5e8952cce789
Autor:
Erika Zodda, Olga Tura-Ceide, Nicholas L Mills, Josep Tarragó-Celada, Marina Carini, Timothy M Thomson, Marta Cascante
Publikováno v:
eLife, Vol 12 (2023)
Compelling evidence has accumulated on the role of oxidative stress on the endothelial cell (EC) dysfunction in acute coronary syndrome. Unveiling the underlying metabolic determinants has been hampered by the scarcity of appropriate cell models to a
Externí odkaz:
https://doaj.org/article/21b6c17d588e4c159a9b8f2a12c12312
Autor:
Adrián Povo-Retana, Marco Fariñas, Rodrigo Landauro-Vera, Marina Mojena, Carlota Alvarez-Lucena, Miguel A. Fernández-Moreno, Antonio Castrillo, Juan Vladimir de la Rosa Medina, Sergio Sánchez-García, Carles Foguet, Francesc Mas, Silvia Marin, Marta Cascante, Lisardo Boscá
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In recent years, the central role of cell bioenergetics in regulating immune cell function and fate has been recognized, giving rise to the interest in immunometabolism, an area of research focused on the interaction between metabolic regulation and
Externí odkaz:
https://doaj.org/article/8c93cd93dcf841ecb1190e4b14b667a4
Autor:
Adrián Povo-Retana, Rodrigo Landauro-Vera, Carlota Alvarez-Lucena, Marta Cascante, Lisardo Boscá
Publikováno v:
Molecules, Vol 29, Iss 2, p 331 (2024)
Trabectedin (TRB) and Lurbinectedin (LUR) are alkaloid compounds originally isolated from Ecteinascidia turbinata with proven antitumoral activity. Both molecules are structural analogues that differ on the tetrahydroisoquinoline moiety of the C subu
Externí odkaz:
https://doaj.org/article/f6708627708845a8ba2ab2c1ebc5db8d
Autor:
Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins, Marjan Geugien, Alan Cunningham, Maurien G. Pruis, Isabel Weinhäuser, Albert Gerding, Barbara M. Bakker, Albertus T. J. Wierenga, Eduardo M. Rego, Gerwin Huls, Marta Cascante, Jan Jacob Schuringa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Inhibition of specific metabolic pathways often drives metabolic adaptation. Here, the authors show that FLT3-ITD + acute myeloid leukemia cells are OXPHOS-driven, and inhibition of complex II activity results in increased lactate influx to drive res
Externí odkaz:
https://doaj.org/article/c6190c32ad6545bcbde3640dce0f4ff7
Autor:
Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins, Roldán Cortés, Alan Cunningham, Maurien G. Pruis, Bauke de Boer, Fiona A. J. van den Heuvel, Marjan Geugien, Albertus T. J. Wierenga, Annet Z. Brouwers-Vos, Eduardo M. Rego, Gerwin Huls, Marta Cascante, Jan Jacob Schuringa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Acute myeloid leukemia (AML) is genetically a very heterogeneous disease. Here, Erdem et al. uncover heterogeneity in the metabolic landscape of AML and identify Pyruvate dehydrogenase kinase 1 (PDK1) as a targetable determinant of different metaboli
Externí odkaz:
https://doaj.org/article/0f8fe7450b4e4f25a3960cce038a7ad3
Autor:
Xavier Capo, Aina Maria Galmes-Panades, Cayetano Navas-Enamorado, Ana Ortega-Moral, Silvia Marín, Marta Cascante, Andrés Sánchez-Polo, Luis Masmiquel, Margalida Torrens-Mas, Marta Gonzalez-Freire
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12751 (2023)
This study aimed to assess the relationship between age-related changes in Neurofilament Light Chain (NFL), a marker of neuronal function, and various factors including muscle function, body composition, and metabolomic markers. The study included 40
Externí odkaz:
https://doaj.org/article/c86270cb2f644d08b7f6ffcf2a3bbc23
Autor:
Leire Pedrosa, Carles Foguet, Helena Oliveres, Iván Archilla, Marta García de Herreros, Adela Rodríguez, Antonio Postigo, Daniel Benítez-Ribas, Jordi Camps, Miriam Cuatrecasas, Antoni Castells, Aleix Prat, Timothy M. Thomson, Joan Maurel, Marta Cascante
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Existing immune signatures and tumor mutational burden have only modest predictive capacity for the efficacy of immune check point inhibitors. In this study, we developed an immune-metabolic signature suitable for personalized ICI therapies. A classi
Externí odkaz:
https://doaj.org/article/cc714daff1e1497f851797bec7a612cf
Autor:
Alejandro Lillo, Silvia Marin, Joan Serrano-Marín, Nicolas Binetti, Gemma Navarro, Marta Cascante, Juan Sánchez-Navés, Rafael Franco
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
The composition of the aqueous humor of patients with glaucoma is relevant to understand the underlying causes of the pathology. Information on the concentration of metabolites and small molecules in the aqueous humor of healthy subjects is limited.
Externí odkaz:
https://doaj.org/article/fb804306dada4773bb145e8ebef4fcaa
Autor:
Sarath Babu Nukala, Olga Tura-Ceide, Giancarlo Aldini, Valérie F. E. D. Smolders, Isabel Blanco, Victor I. Peinado, Manuel Castellà, Joan Albert Barberà, Alessandra Altomare, Giovanna Baron, Marina Carini, Marta Cascante, Alfonsina D’Amato
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a vascular disease characterized by the presence of organized thromboembolic material in pulmonary arteries leading to increased vascular resistance, heart failure and death. Dysfuncti
Externí odkaz:
https://doaj.org/article/5b58cd2d35b441059203f2fa2fb851ca