Fundamental immune–oncogenicity trade-offs define driver mutation fitness

Autor: David Hoyos, Roberta Zappasodi, Isabell Schulze, Zachary Sethna, Kelvin César de Andrade, Dean F. Bajorin, Chaitanya Bandlamudi, Margaret K. Callahan, Samuel A. Funt, Sine R. Hadrup, Jeppe S. Holm, Jonathan E. Rosenberg, Sohrab P. Shah, Ignacio Vázquez-García, Britta Weigelt, Michelle Wu, Dmitriy Zamarin, Laura F. Campitelli, Edward J. Osborne, Mark Klinger, Harlan S. Robins, Payal P. Khincha, Sharon A. Savage, Vinod P. Balachandran, Jedd D. Wolchok, Matthew D. Hellmann, Taha Merghoub, Arnold J. Levine, Marta Łuksza, Benjamin D. Greenbaum

Publikováno v: Hoyos, D, Zappasodi, R, Schulze, I, Sethna, Z, de Andrade, K C, Bajorin, D F, Bandlamudi, C, Callahan, M K, Funt, S A, Hadrup, S R, Holm, J S, Rosenberg, J E, Shah, S P, Vázquez-García, I, Weigelt, B, Wu, M, Zamarin, D, Campitelli, L F, Osborne, E J, Klinger, M, Robins, H S, Khincha, P P, Savage, S A, Balachandran, V P, Wolchok, J D, Hellmann, M D, Merghoub, T, Levine, A J, Łuksza, M & Greenbaum, B D 2022, ' Fundamental immune–oncogenicity trade-offs define driver mutation fitness ', Nature, vol. 606, pp. 172-179 . https://doi.org/10.1038/s41586-022-04696-z

Missense driver mutations in cancer are concentrated in a few hotspots1. Various mechanisms have been proposed to explain this skew, including biased mutational processes2, phenotypic differences3–6 and immunoediting of neoantigens7,8; however, to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788159a08120de98426bcab992e37aaa
https://doi.org/10.1038/s41586-022-04696-z

Clinical and Genomic Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Infections in mRNA Vaccinated Health Care Personnel in New York City

Autor: Tobias M. Hohl, Chester Poon, N. Esther Babady, Michael Lässig, Deborah Korenstein, Karissa Whiting, Benjamin D. Greenbaum, Tracy McMillen, Denis Ruchnewitz, Suzanne Kelson, Krupa Jani, Kevin P. Browne, Alexander Solovyov, Rebecca S. Guest, Scott Freeswick, Anabella Lucca, Venkatraman E. Seshan, Elizabeth Robilotti, Marta Łuksza, Mini Kamboj

Publikováno v: Clin Infect Dis

Background Vaccine-induced clinical protection against severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) variants is an evolving target. There are limited genomic level data on SARS CoV-2 breakthrough infections and vaccine effectiveness (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4ed37aea4299b57bfc05bb01571c42
https://europepmc.org/articles/PMC9612794/

Role of AID in the temporal pattern of acquisition of driver mutations in multiple myeloma

Autor: Kylee H Maclachlan, Benjamin Diamond, Marta Łuksza, Elli Papaemmanuil, Francesco Maura, David Hoyos, Gareth J. Morgan, Even H Rustad, Venkata Yellapantula, Benjamin Greenbaum, Alexander M. Lesokhin, Ola Landgren

Publikováno v: Leukemia. 34:1476-1480

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08ecddf0116b36c723684775522e9a29
https://doi.org/10.1038/s41375-019-0689-0

Fundamental immune-oncogenicity trade-offs define driver mutation fitness

Autor: David, Hoyos, Roberta, Zappasodi, Isabell, Schulze, Zachary, Sethna, Kelvin César, de Andrade, Dean F, Bajorin, Chaitanya, Bandlamudi, Margaret K, Callahan, Samuel A, Funt, Sine R, Hadrup, Jeppe S, Holm, Jonathan E, Rosenberg, Sohrab P, Shah, Ignacio, Vázquez-García, Britta, Weigelt, Michelle, Wu, Dmitriy, Zamarin, Laura F, Campitelli, Edward J, Osborne, Mark, Klinger, Harlan S, Robins, Payal P, Khincha, Sharon A, Savage, Vinod P, Balachandran, Jedd D, Wolchok, Matthew D, Hellmann, Taha, Merghoub, Arnold J, Levine, Marta, Łuksza, Benjamin D, Greenbaum

Publikováno v: Nature. 606(7912)

Missense driver mutations in cancer are concentrated in a few hotspots

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee1a0a2d5947f6c1e1c6274891165a11
https://pubmed.ncbi.nlm.nih.gov/35641605

Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection

Autor: Jiajie Wei, Paul Digard, Robert J. Gifford, Nerea Irigoyen, Megan K. L. MacLeod, Alessandro Vannini, James P. Gibbs, Laura Campisi, Brad R. Rosenberg, Joshua D. Jones, Max W. Chang, Cheng Huang, Quan Gu, Edward C. Hutchinson, Veronica V. Rezelj, Christopher Benner, Helen M. Wise, Jessica Sook Yuin Ho, Jeffrey R. Johnson, Guojun Wang, Matthew Angel, Yesai Fstkchyan, Slobodan Paessler, Robyn M. Kaake, Nan Zhao, Maria João Amorim, Marta Alenquer, Elizabeth Sloan, Sara Clohisey, Ingeborg van Knippenberg, Harm van Bakel, Simin Zheng, Nevan J. Krogan, Liliane Chung, Adam M. Dinan, Bo Wang, Benjamin Greenbaum, Léa Meyer, Natasha Moshkina, Ian Brierley, Zeyu Zhu, Zuleyma Peralta, Adolfo García-Sastre, Andrew E. Firth, Marta Łuksza, Emily R. Miraldi, Vladimir Roudko, Ivan Marazzi, Rong Shen, Carles Martínez-Romero, Yixuan Ma, Jonathan W. Yewdell, J Kenneth Baillie, Justine Noel

Publikováno v: Yuin Ho, J S, Angel, M, Ma, Y, Sloan, E, Wang, G, Martinez-Romero, C, Alenquer, M, Roudko, V, Chung, L, Zheng, S, Chang, M, Fstkchyan, Y, Clohisey, S, Dinan, A M, Gibbs, J, Gifford, R, Shen, R, Gu, Q, Irigoyen, N, Campisi, L, Huang, C, Zhao, N, Jones, J, van Knippenberg, I, Zhu, Z, Moshkina, N, Meyer, L, Noel, J, Peralta, Z, Rezelji, V, Kaake, R, Rosenberg, B, Wang, B, Wei, J, Paessler, S, Wise, H, Johnson, J, Vannini, A, Amorim, M J, Baillie, K, Miraldi, E R, Benner, C, Brierley, I, Digard, P, Luksza, M, Firth, A E, Krogan, N J, Greenbaum, B D, MacLeod, M K, van Bakel, H, García-Sastre, A, Yewdell, J W, Hutchinson, E & Marrazi, I 2020, ' Hybrid Gene Origination Creates Human-Virus Chimeric Protein During Infection ', Cell, vol. 181, no. 7, pp. 1502-1517 . https://doi.org/10.1016/j.cell.2020.05.035
Cell

RNA viruses are a major human health threat. The life cycles of many highly pathogenic RNA viruses like influenza A virus (IAV) and Lassa virus depends on host mRNA, as viral polymerases cleave 5’-m7G-capped host transcripts to primeviral mRNA synt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63665551fab0a3b9b7b770a82f00e7e2
https://www.repository.cam.ac.uk/handle/1810/307677