Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mart Reimund"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract GPIHBP1 is a membrane protein of endothelial cells that transports lipoprotein lipase (LPL), the key enzyme in plasma triglyceride metabolism, from the interstitial space to its site of action on the capillary lumen. An intrinsically disorde
Externí odkaz:
https://doaj.org/article/84b0ce60737e4d47b052cf5285bc2ebf
Autor:
Yuki Takechi-Haraya, Takashi Ohgita, Akiko Usui, Kazuchika Nishitsuji, Kenji Uchimura, Yasuhiro Abe, Ryuji Kawano, Monika I. Konaklieva, Mart Reimund, Alan T. Remaley, Yoji Sato, Ken-ichi Izutsu, Hiroyuki Saito
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Amphipathic arginine-rich peptide, A2-17, exhibits moderate perturbation of lipid membranes and the highest cell penetration among its structural isomers. We investigated the direct cell-membrane penetration mechanism of the A2-17 peptide wh
Externí odkaz:
https://doaj.org/article/b8893099f948499b954ee0db0b116037
Autor:
Denis Sviridov, Amaury Dasseux, Mart Reimund, Milton Pryor, Steven K. Drake, Zack Jarin, Anna Wolska, Richard W. Pastor, Alan T. Remaley
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
IntroductionDefects in lipolysis can lead to hypertriglyceridemia, which can trigger acute pancreatitis and is also associated with cardiovascular disease. Decreasing plasma triglycerides (TGs) by activating lipoprotein lipase (LPL) with ApoC2 mimeti
Externí odkaz:
https://doaj.org/article/80c53a85249945169ab2f857e1ff211d
Autor:
Alexander V. Sorokin, Nidhi Patel, Khaled M. Abdelrahman, Clarence Ling, Mart Reimund, Giorgio Graziano, Maureen Sampson, Martin P. Playford, Amit K. Dey, Aarthi Reddy, Heather L. Teague, Michael Stagliano, Marcelo Amar, Marcus Y. Chen, Nehal N. Mehta, Alan T. Remaley
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Background Although traditional lipid parameters and coronary imaging techniques are valuable for cardiovascular disease (CVD) risk prediction, better diagnostic tests are still needed.Methods In a prospective, observational study, 795 individuals ha
Externí odkaz:
https://doaj.org/article/0c2ae35520764488ac625db69c01b9bd
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 1, Pp 279-288 (2017)
LPL hydrolyzes triglycerides in plasma lipoproteins. Due to the complex regulation mechanism, it has been difficult to mimic the physiological conditions under which LPL acts in vitro. We demonstrate that isothermal titration calorimetry (ITC), using
Externí odkaz:
https://doaj.org/article/a5870ebc47cf4a07a96a883ffc3a4a01
Publikováno v:
Cells, Vol 10, Iss 3, p 597 (2021)
Since the seminal breakthrough of treating diabetic patients with insulin in the 1920s, there has been great interest in developing other proteins and their peptide mimetics as therapies for a wide variety of other medical disorders. Currently, there
Externí odkaz:
https://doaj.org/article/e6a998dff60c4075b28f43e92bddf41a
Publikováno v:
Current opinion in lipidology. 31(3)
PURPOSE OF REVIEW Apolipoprotein C-II (apoC-II) is a critical cofactor for the activation of lipoprotein lipase (LPL), a plasma enzyme that hydrolyzes triglycerides (TG) on TG-rich lipoproteins (TRL). Although apoC-II was first discovered nearly 50 y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6948a19e17a4d0364b83582216942e54
https://pubmed.ncbi.nlm.nih.gov/32332429
https://pubmed.ncbi.nlm.nih.gov/32332429
Autor:
Hans J. Reich, Jasper Adamson, Elina Kalenius, Riina Aav, Filip Topić, Aivar Lookene, Mart Reimund, Kari Rissanen, Elena Prigorchenko, Mario Öeren, Sandra Kaabel, Anniina Kiesilä
Publikováno v:
Chemical Science. 8:2184-2190
A novel eight-membered macrocycle of the hemicucurbit[n]uril family, chiral (all-R)-cyclohexanohemicucurbit[8]uril (cycHC[8]) binds anions in a purely protic solvent with remarkable selectivity. The cycHC[8] portals open and close to fully encapsulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7fd8dfa58215bf0f616074ccab4a31
https://doi.org/10.1039/c6sc05058a
https://doi.org/10.1039/c6sc05058a
Autor:
Aivar Lookene, Robert Risti, Anna Wolska, Alan T. Remaley, Denis Sviridov, Sierra Wilson, Mart Reimund
Publikováno v:
Biochemical and biophysical research communications. 519(1)
Elevated plasma triglyceride (TG) levels are associated with higher risk of atherosclerotic cardiovascular disease. One way to reduce plasma TG is to increase the activity of lipoprotein lipase (LPL), the rate limiting enzyme in plasma TG metabolism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9199aadec13ecd627ca15ae8fd56fc1
https://pubmed.ncbi.nlm.nih.gov/31477272
https://pubmed.ncbi.nlm.nih.gov/31477272
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1865:158553
Pancreatic lipase (PNLIP) is a digestive enzyme that is a potential drug target for the treatment of obesity. A better understanding of its regulation mechanisms would facilitate the development of new therapeutics. Recent studies indicate that intes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac0968649e84de9735195521ac213b5
https://doi.org/10.1016/j.bbalip.2019.158553
https://doi.org/10.1016/j.bbalip.2019.158553