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Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol.

Autor: Jiménez-Juliana M; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), C/ Nicolás Cabrera 1, Madrid 28049, Spain., Martínez-Jiménez MI; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), C/ Nicolás Cabrera 1, Madrid 28049, Spain., Blanco L; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), C/ Nicolás Cabrera 1, Madrid 28049, Spain. Electronic address: lblanco@cbm.csic.es.

Publikováno v: DNA repair [DNA Repair (Amst)] 2024 Nov; Vol. 143, pp. 103772. Date of Electronic Publication: 2024 Oct 07.

Identification of West Nile virus RNA-dependent RNA polymerase non-nucleoside inhibitors by real-time high throughput fluorescence screening.

Autor: García-Zarandieta M; Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660, Boadilla del Monte, Spain., Quesada E; Instituto de Química Médica (IQM, CSIC), 28006, Madrid, Spain., Martínez-Jiménez MI; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), Cantoblanco, E-28049, Madrid, Spain., Newnes CV; Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660, Boadilla del Monte, Spain., Fernández-Cabello V; Instituto de Química Médica (IQM, CSIC), 28006, Madrid, Spain., Sáez-Álvarez Y; Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660, Boadilla del Monte, Spain., Blázquez AB; Departamento de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, (INIA, CSIC), 289040, Madrid, Spain., Escribano-Romero E; Departamento de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, (INIA, CSIC), 289040, Madrid, Spain., Saiz JC; Departamento de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, (INIA, CSIC), 289040, Madrid, Spain., Del Aguila C; Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660, Boadilla del Monte, Spain., Martín-Acebes MA; Departamento de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, (INIA, CSIC), 289040, Madrid, Spain., Pérez-Pérez MJ; Instituto de Química Médica (IQM, CSIC), 28006, Madrid, Spain., Agudo R; Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660, Boadilla del Monte, Spain. Electronic address: ruben.agudotorres@ceu.es.

Publikováno v: Antiviral research [Antiviral Res] 2023 Apr; Vol. 212, pp. 105568. Date of Electronic Publication: 2023 Feb 24.

Motif WFYY of human PrimPol is crucial to stabilize the incoming 3'-nucleotide during replication fork restart.

Autor: Calvo PA; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, 28049, Madrid, Spain., Martínez-Jiménez MI; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, 28049, Madrid, Spain., Díaz M; Spanish National Cancer Research Centre (CNIO), 28029, Madrid, Spain., Stojkovic G; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden., Kasho K; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden.; Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan., Guerra S; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, 28049, Madrid, Spain., Wanrooij S; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden., Méndez J; Spanish National Cancer Research Centre (CNIO), 28029, Madrid, Spain., Blanco L; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, 28049, Madrid, Spain.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2021 Aug 20; Vol. 49 (14), pp. 8199-8213.

Identifying the role of PrimPol in TDF-induced toxicity and implications of its loss of function mutation in an HIV+ patient.

Autor: Duong VN; Department of Pharmacology, Yale School of Medicine, 06510, New Haven, Connecticut, USA., Zhou L; Department of Pediatrics, Yale School of Medicine, 06510, New Haven, Connecticut, USA., Martínez-Jiménez MI; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, 28049, Madrid, Spain., He L; Department of Pharmacology, Yale School of Medicine, 06510, New Haven, Connecticut, USA., Cosme M; Department of Pediatrics, Yale School of Medicine, 06510, New Haven, Connecticut, USA., Blanco L; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, 28049, Madrid, Spain. lblanco@cbm.csic.es., Paintsil E; Department of Pharmacology, Yale School of Medicine, 06510, New Haven, Connecticut, USA. elijah.paintsil@yale.edu.; Department of Pediatrics, Yale School of Medicine, 06510, New Haven, Connecticut, USA. elijah.paintsil@yale.edu.; Department of Epidemiology & Public Health, Yale School of Medicine, 06510, New Haven, Connecticut, USA. elijah.paintsil@yale.edu., Anderson KS; Department of Pharmacology, Yale School of Medicine, 06510, New Haven, Connecticut, USA. karen.anderson@yale.edu.; Department of Molecular Biophysics and Biochemistry, Yale University, 06510, New Haven, Connecticut, United States of America. karen.anderson@yale.edu.

Publikováno v: Scientific reports [Sci Rep] 2020 Jun 09; Vol. 10 (1), pp. 9343. Date of Electronic Publication: 2020 Jun 09.