ctDNA whole exome sequencing in pancreatic ductal adenocarcinoma unveils organ-dependent metastatic mechanisms and identifies actionable alterations in fast progressing patients.

Autor: Huerta M; Department of Medical Oncology, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, Spain; CIBERONC, Instituto de Salud Carlos III, Madrid, Spain., Martín-Arana J; Department of Medical Oncology, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, Spain; CIBERONC, Instituto de Salud Carlos III, Madrid, Spain., Gimeno-Valiente F; Cancer Evolution and Genome Instability Laboratory, University College London Cancer Institute, London, UK., Carbonell-Asins JA; Biostatistics Unit, INCLIVA Biomedical Research Institute, University of Valencia, Spain., García-Micó B; Department of Medical Oncology, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, Spain; CIBERONC, Instituto de Salud Carlos III, Madrid, Spain., Martínez-Castedo B; Department of Medical Oncology, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, Spain; CIBERONC, Instituto de Salud Carlos III, Madrid, Spain., Robledo-Yagüe F; Bioinformatics Unit, INCLIVA Biomedical Research Institute, University of Valencia, Spain., Camblor DG; Department of Medical Oncology, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, Spain., Fleitas T; Department of Medical Oncology, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, Spain; CIBERONC, Instituto de Salud Carlos III, Madrid, Spain., García Bartolomé M; Department of Medical Oncology, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, Spain., Alfaro-Cervelló C; Department of Pathology, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, Spain., Garcés-Albir M; Liver, Biliary and Pancreatic Unit, Department of General Surgery, INCLIVA Biomedical Research Institute, Hospital Clínico Universitario de Valencia, University of Valencia, Valencia, Spain., Dorcaratto D; Liver, Biliary and Pancreatic Unit, Department of General Surgery, INCLIVA Biomedical Research Institute, Hospital Clínico Universitario de Valencia, University of Valencia, Valencia, Spain., Muñoz-Forner E; Liver, Biliary and Pancreatic Unit, Department of General Surgery, INCLIVA Biomedical Research Institute, Hospital Clínico Universitario de Valencia, University of Valencia, Valencia, Spain., Seguí V; Department of Medical Oncology, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, Spain., Mora-Oliver I; Liver, Biliary and Pancreatic Unit, Department of General Surgery, INCLIVA Biomedical Research Institute, Hospital Clínico Universitario de Valencia, University of Valencia, Valencia, Spain., Gambardella V; Department of Medical Oncology, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, Spain; CIBERONC, Instituto de Salud Carlos III, Madrid, Spain., Roselló S; Department of Medical Oncology, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, Spain; CIBERONC, Instituto de Salud Carlos III, Madrid, Spain., Sabater L; Liver, Biliary and Pancreatic Unit, Department of General Surgery, INCLIVA Biomedical Research Institute, Hospital Clínico Universitario de Valencia, University of Valencia, Valencia, Spain., Roda D; Department of Medical Oncology, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, Spain; CIBERONC, Instituto de Salud Carlos III, Madrid, Spain., Cervantes A; Department of Medical Oncology, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, Spain; CIBERONC, Instituto de Salud Carlos III, Madrid, Spain. Electronic address: andres.cervantes@uv.es., Tarazona N; Department of Medical Oncology, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, Spain; CIBERONC, Instituto de Salud Carlos III, Madrid, Spain. Electronic address: noetalla@incliva.es.

Publikováno v: Translational research : the journal of laboratory and clinical medicine [Transl Res] 2024 Sep; Vol. 271, pp. 105-115. Date of Electronic Publication: 2024 May 21.

918P Deciphering the molecular drivers behind locoregional progression, intratumoral heterogeneity, and clonal evolution in locally advanced head and neck cancer

Autor: Bruixola, G., Martin-Arana, J., Gimeno-Valiente, F., Català-Senent, J.F., Carbonell-Asins, J.A., Alfaro-Cervello, C., Camblor, D.G., Martínez-Castedo, B., García-Mico, B., Grimalt Ferrer, N., Segui-Manzaneque, V., Escorihuela-García, V., Léon-Guijarro, J.L., Iglesias, M.E., Dualde, D., Pons, O., Cervantes, A., Tarazona Llavero, N.

Publikováno v: In Annals of Oncology September 2024 35 Supplement 2:S644-S644