Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Martín Estrada-Valencia"'
1
Akademický článek
New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties
Autor: Martín Estrada-Valencia, Clara Herrera-Arozamena, Concepción Pérez, Dolores Viña, José A. Morales-García, Ana Pérez-Castillo, Eva Ramos, Alejandro Romero, Erik Laurini, Sabrina Pricl, María Isabel Rodríguez-Franco
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 712-727 (2019)
The design of multi-target directed ligands (MTDLs) is a valid approach for obtaining effective drugs for complex pathologies. MTDLs that combine neuro-repair properties and block the first steps of neurotoxic cascades could be the so long wanted rem
Externí odkaz: https://doaj.org/article/ed3ffb901f804e3298167947f93fccbc
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2
Akademický článek
Synthesis and Biological Assessment of 4,1-Benzothiazepines with Neuroprotective Activity on the Ca2+ Overload for the Treatment of Neurodegenerative Diseases and Stroke
Autor: Lucía Viejo, Marcos Rubio-Alarcón, Raquel L. Arribas, Manuel Moreno-Castro, Raquel Pérez-Marín, María Braun-Cornejo, Martín Estrada-Valencia, Cristóbal de los Ríos
Publikováno v: Molecules, Vol 26, Iss 15, p 4473 (2021)
In excitable cells, mitochondria play a key role in the regulation of the cytosolic Ca2+ levels. A dysregulation of the mitochondrial Ca2+ buffering machinery derives in serious pathologies, where neurodegenerative diseases highlight. Since the mitoc
Externí odkaz: https://doaj.org/article/9df0f4b8e4fb4447858d66485f9b2489
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3
Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades
Autor: Clara Herrera-Arozamena, Martín Estrada-Valencia, Patricia López-Caballero, Concepción Pérez, José A. Morales-García, Ana Pérez-Castillo, Eric del Sastre, Cristina Fernández-Mendívil, Pablo Duarte, Patrycja Michalska, José Lombardía, Sergio Senar, Rafael León, Manuela G. López, María Isabel Rodríguez-Franco
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
By replacing a phenolic ring of (E)-resveratrol with an 1,3,4-oxadiazol-2(3H)-one heterocycle, new resveratrol-based multi- target-directed ligands (MTDLs) were obtained. They were evaluated in several assays related to oxidative stress and inflammat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba29a16c8d4c68e2a43e88dfcdc7e35c
http://hdl.handle.net/10261/270182
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4
Synthesis and Biological Assessment of 4,1-Benzothiazepines with Neuroprotective Activity on the Ca2+ Overload for the Treatment of Neurodegenerative Diseases and Stroke
Autor: Raquel Pérez-Marín, María Braun-Cornejo, Manuel Moreno-Castro, Cristóbal de los Ríos, Raquel L Arribas, Marcos Rubio-Alarcón, Martín Estrada-Valencia, Lucía Viejo
Publikováno v: Molecules
Volume 26
Issue 15
Molecules, Vol 26, Iss 4473, p 4473 (2021)
In excitable cells, mitochondria play a key role in the regulation of the cytosolic Ca2+ levels. A dysregulation of the mitochondrial Ca2+ buffering machinery derives in serious pathologies, where neurodegenerative diseases highlight. Since the mitoc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e201586b80cfb02e6ce6cd330d93738a
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5
New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties
Autor: Dolores Viña, Erik Laurini, Concepción Pérez, José A. Morales-García, Eva Ramos, Sabrina Pricl, María Isabel Rodríguez-Franco, Ana Perez-Castillo, Clara Herrera-Arozamena, Alejandro Romero, Martín Estrada-Valencia
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 712-727 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry
Digital.CSIC. Repositorio Institucional del CSIC
instname
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
The design of multi-target directed ligands (MTDLs) is a valid approach for obtaining effective drugs for complex pathologies. MTDLs that combine neuro-repair properties and block the first steps of neurotoxic cascades could be the so long wanted rem
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2268ce68b4d3f496cbf99e667b2ec2a1
https://doaj.org/article/ed3ffb901f804e3298167947f93fccbc
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6
Optical control of muscular nicotinic channels with azocuroniums, photoswitchable azobenzenes bearing two N-methyl-N-carbocyclic quaternary ammonium groups
Autor: Concepción Pérez, Clara Herrera-Arozamena, Olaia Martí-Marí, María Isabel Rodríguez-Franco, Mario de la Fuente Revenga, Carlos A. Villalba-Galea, Martín Estrada-Valencia
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
By linking two N-methyl-N-carbocyclic quaternary ammonium groups to an azobenzene scaffold in meta- or para-positions we generated a series of photoswitchable neuromuscular ligands for which we coined the term “azocuroniums”. These compounds swit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf3cdf80ed4edae8f488ee4d249b1d8
http://hdl.handle.net/10261/217685
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7
Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties
Autor: Ana Perez-Castillo, Laura Lagartera, Raquel Fernández-Ginés, Rafael León, María Isabel Rodríguez-Franco, Clara Herrera-Arozamena, Martín Estrada-Valencia, Ángel Juan García-Yagüe, Alberto Mills, Juan Felipe Franco-Gonzalez, Concepción Pérez, Manuela G. López, José A. Morales-García, Pablo Daniel Palacios Duarte, Patrycja Michalska, Antonio Cuadrado, Federico Gago
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
New multi-target indole and naphthalene derivatives containing the oxadiazolone scaffold as a bioisostere of the melatonin acetamido group have been developed. The novel compounds were characterized at melatonin receptors MT1R and MT2R, quinone reduc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9734c3a96d31d970da006c9946324156
http://hdl.handle.net/10261/219073
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8
Structure-activity relationship of potent photo-switchable neuromuscular inhibitors
Autor: María Isabel Rodríguez-Franco, Carlos A. Villalba-Galea, Martín Estrada-Valencia, Clara Herrera-Arozamena
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Muscular nicotinic acetylcholine receptors (nAChR) are ligand-gated ion channels located in the plasma membrane of the post-junctional motor endplate in skeletal muscles. These receptors are responsible for triggering the electrical signal that leads
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98dfb50af3cdf1218f5e4035420191bd
http://hdl.handle.net/10261/206136
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9
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors
Autor: Concepción Pérez, Joana Reis, Stefano Alcaro, Fernanda Borges, José A. Teixeira, Francesco Ortuso, María Isabel Rodríguez-Franco, Martín Estrada Valencia, Eugenio Uriarte, Paulo J. Oliveira, Fernando Cagide, Donatella Bagetta
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
There has been a substantial research effort to design multi-target ligands for the treatment of Alzheimer's disease (AD), an approach that is moved by the knowledge that AD is a complex and multifactorial disease affecting many linked to pathologica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5697ae9fc98c75075ba81dccf17e5212
http://hdl.handle.net/10261/176042
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10
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease
Autor: Dolores Viña, Concepción Pérez, Martín Estrada Valencia, Matilde Yáñez, Ana Perez-Castillo, Eva Ramos, Lucía de Andrés, Alejandro Romero, Erik Laurini, José A. Morales-García, Clara Herrera-Arozamena, Sabrina Pricl, María Isabel Rodríguez-Franco
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
In this work we describe neurogenic and neuroprotective donepezil-flavonoid hybrids (DFHs), exhibiting nanomolar affinities for the sigma-1 receptor and inhibition of key enzymes in Alzheimer's disease (AD), such as acetylcholinesterase (AChE), 5-lip
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247b8a43e5057075006e40205c4adf67
https://www.sciencedirect.com/science/article/pii/S0223523418305828
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