Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Martí Rosés"'
Autor:
Elisabet Fuguet, Martí Rosés
Publikováno v:
Journal of Chromatography Open, Vol 6, Iss , Pp 100189- (2024)
The accurate emulation of biological partition systems through physicochemical models is crucial in pharmacology, toxicology, and environmental science for understanding the ADMET profiles of substances. Direct experimentation on biological systems c
Externí odkaz:
https://doaj.org/article/cf4792c3fbe147ef9bea0a298f8e5d4f
Publikováno v:
Advances in Sample Preparation, Vol 6, Iss , Pp 100063- (2023)
In this work, the characterization of several reversed-phase and HILIC chromatographic systems is presented by means of the Abraham's solvation parameter model, focusing on the impact of solute polarizability, dipolarity, hydrogen bonding, and molecu
Externí odkaz:
https://doaj.org/article/a0695aca80af424ca59e40a3c6dc85b1
Publikováno v:
Membranes, Vol 13, Iss 7, p 640 (2023)
Two parallel artificial membrane permeability assay (PAMPA) systems intended for emulating skin permeability have been characterized through the solvation parameter model of Abraham using multilinear regression analysis. The coefficients of the obtai
Externí odkaz:
https://doaj.org/article/db960de6c55745e8962bf67e9ce3b2f7
Autor:
Alejandro Fernández-Pumarega, Belén Martín-Sanz, Susana Amézqueta, Elisabet Fuguet, Martí Rosés
Publikováno v:
ADMET and DMPK, Vol 8, Iss 1, Pp 98-112 (2020)
The octanol-water partition coefficient (Po/w), or the octanol-water distribution coefficient (Do/w) for ionized compounds, is a key parameter in the drug development process. In a previous work, this parameter was estimated through the retention fac
Externí odkaz:
https://doaj.org/article/c18be40b5ff541f7bd4beaa852e16a95
Publikováno v:
ADMET and DMPK, Vol 8, Iss 1, Pp 16-28 (2020)
In recent years, the parallel artificial membrane permeability assay (PAMPA) has been extended for prediction of skin permeation by developing an artificial membrane which mimics the stratum corneum structure, skin-PAMPA. In the present work, the dif
Externí odkaz:
https://doaj.org/article/d8320ae249354f58ba92808de82ac744
Publikováno v:
Molecules, Vol 28, Iss 3, p 1372 (2023)
Common methods for hold-up time and volume determination in Reversed-Phase Liquid Chromatography (RPLC) have been tested for Hydrophilic Interaction Liquid Chromatography (HILIC). A zwitterionic ZIC-HILIC column has been used for the testing. The pyc
Externí odkaz:
https://doaj.org/article/4601e1018c8a443d95c06c3f2dce56ba
Publikováno v:
ADMET and DMPK, Vol 6, Iss 2, Pp 140-152 (2018)
Dermal absorption is a key process in the drug delivery studies of the pharmaceutical and cosmetic industries, as well as in the fields of dermal toxicology, risk assessment, and the exposure of environmental pollutants. This process is typically des
Externí odkaz:
https://doaj.org/article/54ca671c56104f2f8c9bc6b7dc89e15b
Publikováno v:
ADMET and DMPK, Vol 6, Iss 2, Pp 153-161 (2018)
In the present study a pressure-assisted MEEKC method with reversed-polarity using a conventional CE instrument with UV detection and uncoated fused silica capillaries is validated as a high-throughput methodology for the lipophilicity determination
Externí odkaz:
https://doaj.org/article/7a31f22806ae49d9a5fb46a8f7d6bf92
Publikováno v:
ADMET and DMPK, Vol 6, Iss 1, Pp 55-60 (2018)
Previous studies have shown that a microemulsion electrokinetic chromatography (MEEKC) system can estimate the logarithm of the octanol-water partition coefficient (log Po/w) of neutral solutes. In the present work, the applicability of the method to
Externí odkaz:
https://doaj.org/article/f4f9fbf6dc03493185fdc178c3db6a23
Publikováno v:
ADMET and DMPK, Vol 2, Iss 2, Pp 107-114 (2014)
Predictive software packages to estimate the lipophilicity of molecules have become key tools in the new drug design. Six different well-known computational programs including the classical BioByte-clogP and the GALAS algorithm offered by ACDlabs wer
Externí odkaz:
https://doaj.org/article/72c4da83711b4f8eb0c12ca907bd1730