Magnesium sensing via LFA-1 regulates CD8 ⁺ T cell effector function.

Autor: Lötscher J; Department of Biomedicine, Immunobiology, University of Basel and University Hospital of Basel, 4031 Basel, Switzerland., Martí I Líndez AA; Department of Biomedicine, Immunobiology, University of Basel and University Hospital of Basel, 4031 Basel, Switzerland; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Department of Medicine, CITIID, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK., Kirchhammer N; Department of Biomedicine, Cancer Immunology, University of Basel and University Hospital of Basel, 4031 Basel, Switzerland., Cribioli E; Ludwig Institute for Cancer Research, University of Lausanne, 1066 Epalinges, Switzerland; Department of Oncology, University Hospital of Lausanne, 1011 Lausanne, Switzerland., Giordano Attianese GMP; Ludwig Institute for Cancer Research, University of Lausanne, 1066 Epalinges, Switzerland; Department of Oncology, University Hospital of Lausanne, 1011 Lausanne, Switzerland., Trefny MP; Department of Biomedicine, Cancer Immunology, University of Basel and University Hospital of Basel, 4031 Basel, Switzerland., Lenz M; University of Applied Science Northwestern Switzerland, Institute for Ecopreneurship, 4132 Muttenz, Switzerland., Rothschild SI; Division of Medical Oncology and Comprehensive Cancer Center, University Hospital Basel, 4031 Basel, Switzerland; Swiss Group for Clinical Cancer Research, 3008 Bern, Switzerland., Strati P; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Künzli M; Department of Biomedicine, Immune Cell Biology, University and University Hospital of Basel, 4031 Basel, Switzerland., Lotter C; Department of Pharmaceutical Sciences, Pharmaceutical Technology, University of Basel, 4056 Basel, Switzerland., Schenk SH; Department of Pharmaceutical Sciences, Pharmaceutical Technology, University of Basel, 4056 Basel, Switzerland., Dehio P; Department of Biomedicine, Immunobiology, University of Basel and University Hospital of Basel, 4031 Basel, Switzerland., Löliger J; Department of Biomedicine, Immunobiology, University of Basel and University Hospital of Basel, 4031 Basel, Switzerland., Litzler L; Department of Biomedicine, Immune Cell Biology, University and University Hospital of Basel, 4031 Basel, Switzerland., Schreiner D; Department of Biomedicine, Immune Cell Biology, University and University Hospital of Basel, 4031 Basel, Switzerland., Koch V; Department of Biomedicine, Cancer Immunology, University of Basel and University Hospital of Basel, 4031 Basel, Switzerland., Page N; Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland., Lee D; Department of Biomedicine, Immunobiology, University of Basel and University Hospital of Basel, 4031 Basel, Switzerland., Grählert J; Department of Biomedicine, Immunobiology, University of Basel and University Hospital of Basel, 4031 Basel, Switzerland., Kuzmin D; Hornet Therapeutics Ltd, London SW1Y 5ES, UK; Department of Medical Oncology, Yale School of Medicine, New Haven, CT 06510, USA., Burgener AV; Department of Biomedicine, Immunobiology, University of Basel and University Hospital of Basel, 4031 Basel, Switzerland., Merkler D; Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland., Pless M; Swiss Group for Clinical Cancer Research, 3008 Bern, Switzerland; Department of Oncology, Cantonal Hospital Winterthur, 8400 Winterthur, Switzerland., Balmer ML; Department of Biomedicine, Immunobiology, University of Basel and University Hospital of Basel, 4031 Basel, Switzerland; Department for Biomedical Research (DBMR), University Clinic for Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Inselspital, University of Bern, 3008 Bern, Switzerland; Diabetes Center Berne (DCB), 3010 Bern, Switzerland., Reith W; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland., Huwyler J; Department of Pharmaceutical Sciences, Pharmaceutical Technology, University of Basel, 4056 Basel, Switzerland., Irving M; Ludwig Institute for Cancer Research, University of Lausanne, 1066 Epalinges, Switzerland; Department of Oncology, University Hospital of Lausanne, 1011 Lausanne, Switzerland., King CG; Department of Biomedicine, Immune Cell Biology, University and University Hospital of Basel, 4031 Basel, Switzerland., Zippelius A; Department of Biomedicine, Cancer Immunology, University of Basel and University Hospital of Basel, 4031 Basel, Switzerland; Division of Medical Oncology and Comprehensive Cancer Center, University Hospital Basel, 4031 Basel, Switzerland., Hess C; Department of Biomedicine, Immunobiology, University of Basel and University Hospital of Basel, 4031 Basel, Switzerland; Department of Medicine, CITIID, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK. Electronic address: chess@uhbs.ch.

Publikováno v: Cell [Cell] 2022 Feb 17; Vol. 185 (4), pp. 585-602.e29. Date of Electronic Publication: 2022 Jan 19.

Mitochondrial arginase-2 is a cell‑autonomous regulator of CD8+ T cell function and antitumor efficacy.

Autor: Martí i Líndez AA; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Dunand-Sauthier I; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Conti M; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Gobet F; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Núñez N; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Hannich JT; Department of Biochemistry, NCCR Chemical Biology, University of Geneva, Geneva, Switzerland., Riezman H; Department of Biochemistry, NCCR Chemical Biology, University of Geneva, Geneva, Switzerland., Geiger R; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Piersigilli A; Histology Core Facility, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Hahn K; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Lemeille S; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Becher B; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., De Smedt T; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Hugues S; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Reith W; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Publikováno v: JCI insight [JCI Insight] 2019 Nov 21; Vol. 4 (24). Date of Electronic Publication: 2019 Nov 21.