Výsledky vyhledávání - "Martí Farrera"

Akademický článek

CAR-T overdrive: harnessing inosine for metabolic rewiring and stemness induction

Autor: Martí Farrera-Sal, Michael Schmueck-Henneresse

Publikováno v: Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-2 (2024)

Externí odkaz: https://doaj.org/article/f5f2fe4dc048440c9e96941a56d8d0ef

Akademický článek

cCPE Fusion Proteins as Molecular Probes to Detect Claudins and Tight Junction Dysregulation in Gastrointestinal Cell Lines, Tissue Explants and Patient-Derived Organoids

Autor: Ayk Waldow, Laura-Sophie Beier, Janine Arndt, Simon Schallenberg, Claudia Vollbrecht, Philip Bischoff, Martí Farrera-Sal, Florian N. Loch, Christian Bojarski, Michael Schumann, Lars Winkler, Carsten Kamphues, Lukas Ehlen, Jörg Piontek

Publikováno v: Pharmaceutics, Vol 15, Iss 7, p 1980 (2023)

Claudins regulate paracellular permeability, contribute to epithelial polarization and are dysregulated during inflammation and carcinogenesis. Variants of the claudin-binding domain of Clostridium perfringens enterotoxin (cCPE) are highly sensitive

Externí odkaz: https://doaj.org/article/dd7af9b4ff8a4d9d825bc64bed3e2388

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Akademický článek

Hyaluronidase expression within tumors increases virotherapy efficacy and T cell accumulation

Autor: Martí Farrera-Sal, Rafael Moreno, Ana Mato-Berciano, María Victoria Maliandi, Miriam Bazan-Peregrino, Ramon Alemany

Publikováno v: Molecular Therapy: Oncolytics, Vol 22, Iss , Pp 27-35 (2021)

Oncolytic viruses (OVs) preferentially infect and selectively replicate in cancer cells. OVs have been tested in clinical trials as monotherapy or in combination with chemotherapy, radiotherapy, and immunotherapy. However, the dense extracellular mat

Externí odkaz: https://doaj.org/article/53162dbaea10419f849febb02f78afae

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Akademický článek

Phase I, multicenter, open-label study of intravenous VCN-01 oncolytic adenovirus with or without nab-paclitaxel plus gemcitabine in patients with advanced solid tumors

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)

Background VCN-01 is an oncolytic adenovirus (Ad5 based) designed to replicate in cancer cells with dysfunctional RB1 pathway, express hyaluronidase to enhance virus intratumoral spread and facilitate chemotherapy and immune cells extravasation into

Externí odkaz: https://doaj.org/article/f20744c4524742ac8290f86ad68345d4

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Akademický článek

Targeting the tumor stroma with an oncolytic adenovirus secreting a fibroblast activation protein-targeted bispecific T-cell engager

Autor: Jana de Sostoa, Carlos Alberto Fajardo, Rafael Moreno, Maria D. Ramos, Martí Farrera-Sal, Ramon Alemany

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)

Abstract Background Oncolytic virus (OV)-based therapies have an emerging role in the treatment of solid tumors, involving both direct cell lysis and immunogenic cell death. Nonetheless, tumor-associated stroma limits the efficacy of oncolytic viruse

Externí odkaz: https://doaj.org/article/54699afec5424ff2960cbfd6795cac48

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Akademický článek

Evidence of Anti-tumoral Efficacy in an Immune Competent Setting with an iRGD-Modified Hyaluronidase-Armed Oncolytic Adenovirus

Autor: Ahmed Abdullah Al-Zaher, Rafael Moreno, Carlos Alberto Fajardo, Marcel Arias-Badia, Martí Farrera, Jana de Sostoa, Luis Alfonso Rojas, Ramon Alemany

Publikováno v: Molecular Therapy: Oncolytics, Vol 8, Iss , Pp 62-70 (2018)

To enhance adenovirus-mediated oncolysis, different approaches that tackle the selectivity, tumor penetration, and spreading potential of oncolytic adenoviruses have been reported. We have previously demonstrated that insertion of the internalizing A

Externí odkaz: https://doaj.org/article/0a2e8c7b9ae940cbaf08ac217ac2324d

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Hyaluronidase expression within tumors increases virotherapy efficacy and T cell accumulation

Autor: Miriam Bazan-Peregrino, Ramon Alemany, Maria Victoria Maliandi, Rafael Moreno, Ana Mato-Berciano, Martí Farrera-Sal

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Molecular Therapy: Oncolytics, Vol 22, Iss, Pp 27-35 (2021)
Molecular Therapy Oncolytics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b95bc7488e4c0d1b515d545d3731e8
http://hdl.handle.net/2445/180605

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Transgene codon usage drives viral fitness and therapeutic efficacy in oncolytic adenoviruses

Autor: Giancarlo Castellano, David Medel, Marc Otero-Mateo, Martí Farrera-Sal, Eneko Villanueva, Cristina Fillat, Ramon Alemany, Rafael Moreno, Estela Núñez-Manchón

Publikováno v: NAR Cancer

Arming oncolytic adenoviruses with therapeutic transgenes is a well-established strategy for multimodal tumour attack. However, this strategy sometimes leads to unexpected attenuated viral replication and a loss of oncolytic effects, preventing these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d845b28d51548b355cc8d9ac8359d782
https://doi.org/10.1093/narcan/zcab015

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Oncolytic adenovirus with hyaluronidase activity that evades neutralizing antibodies: VCN-11

Autor: Marcel Arias-Badia, Mireia M. Ginestà, Silvia Torres-Manjon, Sara Morgado, Martí Farrera-Sal, Ana Mato-Berciano, Marta Gimenez-Alejandre, Maria Victoria Maliandi, Luis A. Rojas, Paz Moreno, Manel Cascallo, Miriam Bazan-Peregrino, Ramon Alemany, Rafael Moreno, Gabriel Capellá

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 332

Tumor targeting and intratumoral virus spreading are key features for successful oncolytic virotherapy. VCN-11 is a novel oncolytic adenovirus, genetically modified to express hyaluronidase (PH20) and display an albumin-binding domain (ABD) on the he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d102a70eea1156875df0606cbd0f6929
https://pubmed.ncbi.nlm.nih.gov/33675877

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