Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Mart, Ustav"'
Autor:
Kiira Gildemann, Mari-Liis Tsernant, Laura Liivand, Retti Ennomäe, Väino Poikalainen, Lembit Lepasalu, Siimu Rom, Ants Kavak, Robert Marsden Cox, Josef Dieter Wolf, Carolin Maria Lieber, Richard Karl Plemper, Andres Männik, Mart Ustav, Jr., Mart Ustav, Joachim Matthias Gerhold
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110326- (2024)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread in the population. We recently reported the production of bovine colostrum-derived antibodies that can neutralize the virus. These have been formulated into a n
Externí odkaz:
https://doaj.org/article/4a26311eb5124ea19ecbfdef3d1c104d
Autor:
Xuanming Guo, Pallavi Asthana, Lixiang Zhai, Ka Wing Cheng, Susma Gurung, Jiangang Huang, Jiayan Wu, Yijing Zhang, Arun Kumar Mahato, Mart Saarma, Mart Ustav, Hiu Yee Kwan, Aiping Lyu, Kui Ming Chan, Pingyi Xu, Zhao-Xiang Bian, Hoi Leong Xavier Wong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Obesity, a global health challenge, is a major risk factor for multiple life-threatening diseases, including diabetes, fatty liver, and cancer. There is an ongoing need to identify safe and tolerable therapeutics for obesity management. Here
Externí odkaz:
https://doaj.org/article/a29cc025e9664a529d8c924433238848
Autor:
Erlend Ravlo, Aleksandr Ianevski, Eirin Starheim, Wei Wang, Ping Ji, Hilde Lysvand, Teemu Smura, Gaily Kivi, Maia-Liisa Voolaid, Kati Plaan, Mart Ustav, Mart Ustav, Jr., Eva Zusinaite, Tanel Tenson, Reet Kurg, Valentyn Oksenych, Kirsti Walstad, Svein Arne Nordbø, Mari Kaarbø, Karin Ernits, Magnar Bjørås, Denis E. Kainov, Mona Høysæter Fenstad
Publikováno v:
International Journal of Infectious Diseases, Vol 137, Iss , Pp 75-78 (2023)
Vaccinated convalescents do not develop severe COVID-19 after infection with new SARS-CoV-2 variants. We questioned how messenger RNA (mRNA) vaccination of convalescents provides protection from emerging virus variants. From the cohort of 71 convales
Externí odkaz:
https://doaj.org/article/8098c1ee0a8344b78dfaa169d2000625
Akademický článek
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Autor:
Vera Kovaleva, Li-Ying Yu, Larisa Ivanova, Olesya Shpironok, Jinhan Nam, Ave Eesmaa, Esa-Pekka Kumpula, Sven Sakson, Urve Toots, Mart Ustav, Juha T. Huiskonen, Merja H. Voutilainen, Päivi Lindholm, Mati Karelson, Mart Saarma
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112066- (2023)
Summary: Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-located protein with cytoprotective effects in neurons and pancreatic β cells in vitro and in models of neurodegeneration and diabetes in vivo. Howe
Externí odkaz:
https://doaj.org/article/5219a8ab6680491fa637a30370d90b44
Autor:
Kushal Suryamohan, Devan Diwanji, Eric W. Stawiski, Ravi Gupta, Shane Miersch, Jiang Liu, Chao Chen, Ying-Ping Jiang, Frederic A. Fellouse, J. Fah Sathirapongsasuti, Patrick K. Albers, Tanneeru Deepak, Reza Saberianfar, Aakrosh Ratan, Gavin Washburn, Monika Mis, Devi Santhosh, Sneha Somasekar, G. H. Hiranjith, Derek Vargas, Sangeetha Mohan, Sameer Phalke, Boney Kuriakose, Aju Antony, Mart Ustav Jr, Stephan C. Schuster, Sachdev Sidhu, Jagath R. Junutula, Natalia Jura, Somasekar Seshagiri
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Suryamohan, Diwanji, Stawiski et al. identify natural ACE2 variants that are predicted to alter virus–host interactions. They find that soluble ACE2 K26R and T92I variants are more effective in blocking the entry of SARS-CoV-2 S-protein pseudotyped
Externí odkaz:
https://doaj.org/article/32225ac91a454b1683c6a373e209aa04
Autor:
Kadri Kangro, Mihhail Kurašin, Kiira Gildemann, Eve Sankovski, Eva Žusinaite, Laura Sandra Lello, Raini Pert, Ants Kavak, Väino Poikalainen, Lembit Lepasalu, Marilin Kuusk, Robin Pau, Sander Piiskop, Siimu Rom, Ruth Oltjer, Kairi Tiirik, Karin Kogermann, Mario Plaas, Toomas Tiirats, Birgit Aasmäe, Mihkel Plaas, Karl Mumm, Dagni Krinka, Ene Talpsep, Meelis Kadaja, Joachim M. Gerhold, Anu Planken, Andres Tover, Andres Merits, Andres Männik, Mart Ustav
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to impose a serious burden on health systems globally. Despite worldwide vaccination, social distancing and wearing masks, the spread of the virus is ongoing. One of the mechanism
Externí odkaz:
https://doaj.org/article/ded5bb1380934dd8b51d32fab3b9098b
Autor:
Lisett Liblekas, Alla Piirsoo, Annika Laanemets, Eva-Maria Tombak, Airiin Laaneväli, Ene Ustav, Mart Ustav, Marko Piirsoo
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The life-cycle of human papillomaviruses (HPVs) includes three distinct phases of the viral genome replication. First, the viral genome is amplified in the infected cells, and this amplification is often accompanied by the oligomerization of the vira
Externí odkaz:
https://doaj.org/article/169b0f81cf974ff49b3e8f88487d78ea
Autor:
Ly Porosk, Jekaterina Nebogatova, Heleri Heike Härk, Birgit Vunk, Piret Arukuusk, Urve Toots, Mart Ustav, Ülo Langel, Kaido Kurrikoff
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1949 (2022)
Therapeutic proteins are currently at the apex of innovation in pharmaceutical medicine. However, their industrial production is technically challenging and improved methods for transient transfection of mammalian cell cultures are necessary. We aime
Externí odkaz:
https://doaj.org/article/c4dfbd138aa549bfabe4815d0ae62279
Autor:
Kadri Kangro, Elien Roose, Charlotte Dekimpe, Aline Vandenbulcke, Nuno A.G. Graça, Jan Voorberg, Mart Ustav, Andres Männik, Karen Vanhoorelbeke
Publikováno v:
Journal of thrombosis and haemostasis, 20(10), 2379-2385. Wiley-Blackwell
BACKGROUND: Recombinant human ADAMTS13 (rADAMTS13) is a key protein in fundamental research for investigating its mode of action and the pathophysiology of thrombotic thrombocytopenic purpura (TTP). However, the expression of rADAMTS13 is quite low i