Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Marston Manthorpe"'
Autor:
Jennifer A. Chaplin, Michael Komai, Rodrick Planchon, Adrian Vilalta, David C. Kaslow, Gretchen S. Jimenez, Marston Manthorpe, Alain Rolland, Peggy Lalor, Denis Rusalov, Kristin R. Carner
Publikováno v:
Human Gene Therapy. 18:763-771
The feasibility of a linear expression cassette (LEC)-based influenza A DNA vaccine was demonstrated in mice, using a lethal dose (LD90) of a mouse-adapted A/Hong Kong/8/68 (H3N2) influenza strain. LECs expressing hemagglutinin (HA) from either the h
Publikováno v:
Human Gene Therapy. 9:2545-2553
Enhancers and promoters from various muscle-specific genes were substituted for or combined with the enhancer/promoter of the human cytomegalovirus (CMV) IE gene in a luciferase reporter gene plasmid in an effort to identify new promoter chimeras wit
Autor:
Alan D. Smith, Margaret R. Nichols, Seng H. Cheng, John Marshall, Michael Plewe, Yali J. Tsai, Jennifer B. Nietupski, Loretta Sukhu, Jon Norman, Carl J. Wheeler, S G Doh, Xiaowu Liang, Philip L. Felgner, Marston Manthorpe, Jukka Hartikka
Publikováno v:
Proceedings of the National Academy of Sciences. 93:11454-11459
Effective gene therapy for lung tissue requires the use of efficient vehicles to deliver the gene of interest into lung cells. When plasmid DNA encoding chloramphenicol acetyltransferase (CAT) was administered intranasally to BALB/c mice without carr
Autor:
L M Serfilippi, Craig L. Franklin, Stanislaw H. Gromkowski, Jon Norman, H.L. Vahlsing, S G Doh, Denise Lew, Marston Manthorpe, S E Parker
Publikováno v:
Human Gene Therapy. 6:575-590
To evaluate the safety of a plasmid DNA-lipid complex, a series of good laboratory practice (GLP) safety studies were conducted with VCL-1005, a plasmid DNA expression vector containing both the human class I MHC HLA-B7 heavy-chain and the beta 2-mic
Autor:
Marston Manthorpe, Jiin Felgner, Jukka Hartikka, Francine Cornefert-Jensen, Ann Rundell, Michal Margalith, Varavani Dwarki
Publikováno v:
Scopus-Elsevier
Direct injection of nonviral, covalently closed circular plasmid DNA into muscle results in expression of the DNA in myofiber cells. We have examined the expression of firefly luciferase DNA constructs injected into adult murine skeletal muscle. Cons
Publikováno v:
The Journal of Comparative Neurology. 319:454-462
The role of nerve growth factor (NGF) as a target derived neurotrophic agent for specific cell populations in the peripheral nervous system has been well documented and much evidence suggests that NGF may serve a similar neurotrophic role in the CNS
Publikováno v:
Journal of Neuroscience Research. 31:193-204
We have established a permanent cell line (CG-4) of rat central nervous system glial precursors from primary cultures of bipotential oligodendrocyte-type 2-astrocyte (O-2A) progenitor cells, which were kept proliferating with the mitogen(s) secreted
Autor:
David Muir, Marston Manthorpe
Publikováno v:
The Journal of Cell Biology
Our previous report (Muir, D., S. Varon, and M. Manthorpe. 1990. J. Cell Biol. 109:2663-2672) described the isolation and partial characterization of a 55-kD antiproliferative protein found in Schwann cell (SC) and schwannoma cell line-conditioned me
Autor:
Marston Manthorpe, Brigitte Pettmann
Publikováno v:
Cell Biology and Toxicology. 8:107-115
We have summarized several methodologies currently available for the detection and analysisof protein factors affecting neural cells. As more knowledge is gained concerning growthfactors and their influences on cells and as the demand for bioassays i
Publikováno v:
Experimental Cell Research. 198:115-123
The laminin-like protein merosin was purified from human placenta in intact form and as pepsin fragments and compared to laminin in heparin affinity chromatography and cell binding assays. Intact merosin and a small fragment of merosin comprising the