Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Marson Putra"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Neurodegeneration and neuroinflammation are key processes of epileptogenesis in temporal lobe epilepsy (TLE). A considerable number (∼30%) of patients with epilepsy are resistant to currently available antiseizure drugs and thus there is a need to
Externí odkaz:
https://doaj.org/article/80bd9bddf2c642c8ae1500f79d473c8a
Autor:
Christina Meyer, Nikhil S. Rao, Suraj S. Vasanthi, Beatriz Pereira, Meghan Gage, Marson Putra, Claire Holtkamp, Joselyn Huss, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Organophosphates (OP) are highly toxic chemical nerve agents that have been used in chemical warfare. Currently, there are no effective medical countermeasures (MCMs) that mitigate the chronic effects of OP exposure. Oxidative stress is a key mechani
Externí odkaz:
https://doaj.org/article/ee60e460bdda414980be652438df1986
Autor:
Nikhil S. Rao, Christina Meyer, Suraj S. Vasanthi, Nyzil Massey, Manikandan Samidurai, Meghan Gage, Marson Putra, Aida N. Almanza, Logan Wachter, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Sex is a biological variable in experimental models. In our previous diisopropylfluorophosphate (DFP) studies, female rats required a higher dose of DFP to achieve a somewhat similar severity of status epilepticus (SE) as males. In those studies, mal
Externí odkaz:
https://doaj.org/article/3365a7c48d5447a38cc68c990cfcd13b
Autor:
Meghan Gage, Nikhil S. Rao, Manikandan Samidurai, Marson Putra, Suraj S. Vasanthi, Christina Meyer, Chong Wang, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2022)
Modeling a real-world scenario of organophosphate nerve agent (OPNA) exposure is challenging. Military personnel are premedicated with pyridostigmine, which led to the development of OPNA models with pyridostigmine/oxime pretreatment to investigate n
Externí odkaz:
https://doaj.org/article/631974d04d3d4aefa5b682931e544a3c
Autor:
Meghan Gage, Marson Putra, Crystal Gomez-Estrada, Madison Golden, Logan Wachter, Megan Gard, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Acute organophosphate (OP) toxicity poses a significant threat to both military and civilian personnel as it can lead to a variety of cholinergic symptoms including the development of status epilepticus (SE). Depending on its severity, SE can lead to
Externí odkaz:
https://doaj.org/article/f3f8aabf783b450db21df5b8a538e0c4
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Both Fyn and tau have been associated with neuronal hyperexcitability and neurotoxicity in many tauopathies, including Alzheimer's disease (AD). Individual genetic ablation of fyn or tau appears to be protective against aberrant excitatory neuronal a
Externí odkaz:
https://doaj.org/article/17914f6155d64083aa475a2c34c9ccc7
Autor:
Marson Putra, Shaunik Sharma, Meghan Gage, Grace Gasser, Andy Hinojo-Perez, Ashley Olson, Adriana Gregory-Flores, Sreekanth Puttachary, Chong Wang, Vellareddy Anantharam, Thimmasettappa Thippeswamy
Publikováno v:
Neurobiology of Disease, Vol 133, Iss , Pp - (2020)
Chemical nerve agents (CNA) are increasingly becoming a threat to both civilians and military personnel. CNA-induced acute effects on the nervous system have been known for some time and the long-term consequences are beginning to emerge. In this stu
Externí odkaz:
https://doaj.org/article/ec8378c734124560a9373eeab90c8b8f
Autor:
Shaunik Sharma, Steven Carlson, Sreekanth Puttachary, Souvarish Sarkar, Lucas Showman, Marson Putra, Anumantha G. Kanthasamy, Thimmasettappa Thippeswamy
Publikováno v:
Neurobiology of Disease, Vol 110, Iss , Pp 102-121 (2018)
Status epilepticus (SE) induces neuroinflammation and epileptogenesis, but the mechanisms are not yet fully delineated. The Fyn, a non-receptor Src family tyrosine kinase (SFK), and its immediate downstream target, PKCδ are emerging as potential med
Externí odkaz:
https://doaj.org/article/64a5d7332d2b4d7f80a283ceb395d464
Autor:
Meghan Gage, Marson Putra, Logan Wachter, Kylie Dishman, Megan Gard, Crystal Gomez-Estrada, Thimmasettappa Thippeswamy
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 61 (2021)
Diisopropylfluorophosphate (DFP), an organophosphate nerve agent (OPNA), exposure causes status epilepticus (SE) and epileptogenesis. In this study, we tested the protective effects of saracatinib (AZD0530), a Src kinase inhibitor, in mixed-sex or ma
Externí odkaz:
https://doaj.org/article/b173e9d9b119403fb5059d593f6e9aa9
Autor:
Sreekanth Puttachary, Shaunik Sharma, Saurabh Verma, Yang Yang, Marson Putra, Achala Thippeswamy, Diou Luo, Thimmasettappa Thippeswamy
Publikováno v:
Neurobiology of Disease, Vol 93, Iss , Pp 184-200 (2016)
Status epilepticus (SE) initiates epileptogenesis to transform normal brain to epileptic state which is characterized by spontaneous recurrent seizures (SRS). Prior to SRS, progressive changes occur in the brain soon after SE, for example, loss of bl
Externí odkaz:
https://doaj.org/article/9aef96e86657404e8360478b3f788ea9