Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Marsham PR"'
Autor:
Anthony Ladner, Michael R. O’Donovan, Scott Boyer, Andrew D. Roberts, Adrian Pickup, Marsham Pr, David S. Clarke, Craig S. Donald, Linda Godfrey, David Robert Brittain, Steve Chapman, Paul Schofield, Christine Mee, David J. Masters, Michael Howard Block, Rayner John Wall, J. Elizabeth Pease, Debra Carroll, and Abid Suleman, Wayne Brailsford, Kevin Michael Foote, Andrew V. Turnbull
Publikováno v:
Journal of Medicinal Chemistry. 45:3509-3523
The hypothesis that antagonists of the neuropeptide Y5 receptor would provide safe and effective appetite suppressants for the treatment of obesity has prompted vigorous research to identify suitable compounds. We discovered a series of acylated amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0028b2565d75e49c0cc2a1f31a51be3d
https://doi.org/10.1021/jm011125x
https://doi.org/10.1021/jm011125x
Autor:
R. Kimbell, Andrew John Barker, Marsham Pr, Alan Hilary Calvert, Pegg Sj, F. T. Boyle, Ann L. Jackman, O'Connor Bm, Leslie Richard Hughes, Wardleworth Jm
Publikováno v:
Journal of Medicinal Chemistry. 38:994-1004
The synthesis of a series of analogues of the potent thymidylate synthase (TS) inhibitor N-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6- quinazolinyl)methyl]-N-prop-2-ynylamino]benzoyl]-L-glutamic acid (ICI 198583, 1) is described in which the glutamic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489070076b570c1c951f355179532799
https://doi.org/10.1021/jm00006a019
https://doi.org/10.1021/jm00006a019
Autor:
Marsham Pr
Publikováno v:
Journal of Heterocyclic Chemistry. 31:603-613
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5846a51713f519e97bbc41ec595d7ddf
https://doi.org/10.1002/jhet.5570310302
https://doi.org/10.1002/jhet.5570310302
Autor:
Marsham Pr
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efcc7b81295ef5b4638d8de5cc023a01
https://doi.org/10.1002/chin.199512325
https://doi.org/10.1002/chin.199512325
Publikováno v:
Journal of Medicinal Chemistry. 35:2321-2327
The synthesis of a series of new C2-methyl-N10-alkylquinazoline-based thymidylate synthase (TS) inhibitors containing difluroinated p-aminobenzoate rings is described. Derivatives of the N10-propargyl and N10-methylquinazoline antifolates were prepar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47431877e9d2185c3d34f978e0453994
https://doi.org/10.1021/jm00090a024
https://doi.org/10.1021/jm00090a024
Publikováno v:
Advances in Enzyme Regulation. 31:13-27
Heterocyclic para-aminobenzoate modifications of 2-desamino-2-methyl-5,8-dideazafolic acid and a series of its N10-substituted analogs have produced a number of interesting compounds that have enabled a deeper understanding of the biochemical events
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6c67404ca23a96fab07a73ba123b3a
https://doi.org/10.1016/0065-2571(91)90006-8
https://doi.org/10.1016/0065-2571(91)90006-8
Autor:
Marsham Pr, Alan Hilary Calvert, Thornton Tj, O'Connor Bm, Ann L. Jackman, Leslie Richard Hughes, J. A. M. Bishop, Jones Terence R
Publikováno v:
Journal of Medicinal Chemistry. 33:3067-3071
The synthesis of 2'-fluoro-10-propargyl-5,8-dideazafolic acid and its 2-desamino, 2-desamino-2-hydroxymethyl, and 2-desamino-2-methoxy analogues is described. In general the synthetic route involved the coupling of diethyl N-[2-fluoro-4-(prop-2-ynyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425b61c3d9426619dbb79d44e06d6012
https://doi.org/10.1021/jm00173a025
https://doi.org/10.1021/jm00173a025
Autor:
Martin R. Brown, Kimbell R, Marsham Pr, Wardleworth Jm, F T Boyle, Jackman Al, Laurent Francois Andre Hennequin
Publikováno v:
Journal of medicinal chemistry. 42(19)
The synthesis is described of a series of analogues of the potent thymidylate synthase (TS) inhibitor, N-[4-[N-[(3,4-dihydro-2, 7-dimethyl-4-oxo-6-quinazolinyl)methyl]-N-prop-2-ynylamino]-2-f luorob enzoyl]-L-glutamic acid (4, ZM214888), in which the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2098390e62053c52a36116f5de61104c
https://pubmed.ncbi.nlm.nih.gov/10508430
https://pubmed.ncbi.nlm.nih.gov/10508430
Autor:
Marsham Pr, R. Kimbell, Laurent Francois Andre Hennequin, F. T. Boyle, Ann L. Jackman, Wardleworth Jm
Publikováno v:
Journal of medicinal chemistry. 39(3)
Modification of the potent thymidylate synthase (TS) inhibitor 1-[[N-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N- prop-2-ynylamino]benzoyl]amino]methyl]-3-nitrobenzene (4a) has led to the synthesis of quinazolinone antifolates bearing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3f314b5fe30c79260ef76972944a00
https://pubmed.ncbi.nlm.nih.gov/8576912
https://pubmed.ncbi.nlm.nih.gov/8576912
Autor:
Marsham Pr, Leslie Richard Hughes, J. A. M. Bishop, O'Connor Bm, A. J. Hayter, M. R. Daw, Alan Hilary Calvert, J. L. Snowden, Ann L. Jackman
Publikováno v:
Journal of medicinal chemistry. 34(7)
Several C2-methylquinazoline-based antifolates (14-26) have been prepared in which the C9,N10 bridge has been replaced by the reversed N9,C10 unit. This series was extensively studied by incorporating further substituents at N9 and C10 as well as by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ce689c45eef106fa65dfc7e55d16c0
https://pubmed.ncbi.nlm.nih.gov/2066994
https://pubmed.ncbi.nlm.nih.gov/2066994