Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Marshall Snavely"'
Publikováno v:
Journal of Biomolecular Screening
For the development of therapeutically potent anti-cancer antibody drugs, it is often important to identify antibodies that internalize into cells efficiently, rather than just binding to antigens on the cell surface. Such antibodies can mediate rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31141da1eddb2dc2b4c19df01d04b1d4
https://doi.org/10.1177/1087057115588511
https://doi.org/10.1177/1087057115588511
Autor:
David Surguladze, Kris Persaud, Douglas Burtrum, Sudhakar Chintharlapalli, Aiping Zhu, Marie Prewett, Sagit Hindi, Paul Balderes, Ruslan Novosyadlyy, Yun (Kenneth) Kang, Haifan Zhang, Scott W. Eastman, Juqun Shen, Yang Shen, Lin Zeng, Zhenping Zhu, Nicole Covino, Michael Topper, Marshall Snavely, Dale L. Ludwig, Andrew Ihor Korytko, Amelie Forest, Victor J. Wroblewski
Publikováno v:
mAbs
Bi-specific antibodies (BsAbs), which can simultaneously block 2 tumor targets, have emerged as promising therapeutic alternatives to combinations of individual monoclonal antibodies. Here, we describe the engineering and development of a novel, huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a00cbf92f1f1be13c3a0daff184b98
http://europepmc.org/articles/PMC4623440
http://europepmc.org/articles/PMC4623440
Autor:
Jacqueline Lypowy, Marshall Snavely, Kris Persaud, Amtul Bari, Wei Zhu, Zhiping Weng, Brian G. Pierce, Jaafar N. Haidar, Dale L. Ludwig, Xenia Luna
Publikováno v:
Journal of Molecular Biology. 426:1583-1599
Conformational entropy is an important component of protein-protein interactions; however, there is no reliable method for computing this parameter. We have developed a statistical measure of residual backbone entropy in folded proteins by using the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731d5bef4851739866c9019da078a93d
https://doi.org/10.1016/j.jmb.2013.12.024
https://doi.org/10.1016/j.jmb.2013.12.024
Autor:
Dipa Patel, Qinwei Zhou, Aiping Zhu, Kris Persaud, Tim Blanc, Marshall Snavely, Dale L. Ludwig, Paul Balderes, Anthony Pennello, Yang Shen, David Surguladze, Yun Kenneth Kang, Stanley Ng, Lin Zeng, Sagit Hindi, Amtul Bari
Publikováno v:
mAbs
Optimization of biophysical properties is a critical success factor for the developability of monoclonal antibodies with potential therapeutic applications. The inter-domain disulfide bond between light chain (Lc) and heavy chain (Hc) in human IgG1 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7296d4ce2870870a44f9ba5969f517d8