Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marshall Schreeder"'
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
Pharmacokinetic results at Day 29, by cohort (median [range])
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761803ef4b2434e7ff2418ba535f26e5
https://doi.org/10.1158/1078-0432.22469712
https://doi.org/10.1158/1078-0432.22469712
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
LYC-55716 toxicology thermometer plot indicating a pharmacologically active exposure of 18.6μg·h/mL, based on the upregulation of target genes in mouse thymus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e54a85ba157ea25ab3981c8cf5782f9
https://doi.org/10.1158/1078-0432.22469721.v1
https://doi.org/10.1158/1078-0432.22469721.v1
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
Baseline RORgt (RORC2) expression is variable from patient to patient.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a017a95fe20e70d01be7ff951de0f44d
https://doi.org/10.1158/1078-0432.22469715.v1
https://doi.org/10.1158/1078-0432.22469715.v1
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
Purpose:Transcription factor retinoic acid receptor–related orphan receptor γ (RORγ) regulates type 17 effector T-cell differentiation and function and is key to immune cell regulation. Synthetic RORγ agonists modulate immune cell gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b94f77cf3892037b3e87257e1cdc429
https://doi.org/10.1158/1078-0432.c.6527316.v1
https://doi.org/10.1158/1078-0432.c.6527316.v1
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
Post-treatment changes in IL-17A and pharmacokinetic profiles for Cohort 4a (600 mg QD) and Cohort 4b (300 mg BID). D, day; PD, pharmacodynamics; PK, pharmacokinetics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f39aaacac1168b73f2c09557c63cdd5
https://doi.org/10.1158/1078-0432.22469718.v1
https://doi.org/10.1158/1078-0432.22469718.v1
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
Fold induction over Day 1 pre-dose.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018d87e7dfac7d80c8c4c814cce840ab
https://doi.org/10.1158/1078-0432.22469709.v1
https://doi.org/10.1158/1078-0432.22469709.v1
Autor:
H. Jeffrey Wilkins, L. Carter, Judy S. Wang, Erika Hamilton, John Nemunaitis, Xiao Hu, Devalingam Mahalingam, John Sarantopoulos, Garry Alan Weems, Marshall Schreeder
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(12)
Purpose:Transcription factor retinoic acid receptor–related orphan receptor γ (RORγ) regulates type 17 effector T-cell differentiation and function and is key to immune cell regulation. Synthetic RORγ agonists modulate immune cell gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0a78b01069052f7284b3ae03f41f10
https://pubmed.ncbi.nlm.nih.gov/30819679
https://pubmed.ncbi.nlm.nih.gov/30819679
Autor:
Barbara L. Pruetz, Timothy J. Geddes, Ayat Salman, Anthoula Lazaris, Antonio Campos, Alison Parry-Jones, Dianna M. Larson, Marshall Schreeder, Ahmed Samir Abdelhafiz
Publikováno v:
Biopreservation and biobanking. 13(6)
B iospecimens and data are increasingly needed to support biomedical research and clinical care. Biobanks are created to support the ready access to fit-for-purpose biospecimens and data for drug target identification, drug discovery and development,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472c16f7f258dabd97cb2ff154dbc706
https://pubmed.ncbi.nlm.nih.gov/26697907
https://pubmed.ncbi.nlm.nih.gov/26697907
Autor:
Erika Hamilton, Judy S. Wang, Garry Alan Weems, Marshall Schreeder, H. Jeffrey Wilkins, Devalingam Mahalingam
Publikováno v:
Cancer Research. 78:CT132-CT132
Background: LYC-55716, a first-in-class, oral, small-molecule agonist of the retinoic acid receptor-related orphan receptor γ (RORγ), is under development as a novel immuno-oncology agent for solid tumors. Preclinical data show that LYC-55716 modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d318cd63aedd8a51d6eca3f11e8efebe
https://doi.org/10.1158/1538-7445.am2018-ct132
https://doi.org/10.1158/1538-7445.am2018-ct132
Autor:
Robert C G, Martin, Charles R, Scoggins, Marshall, Schreeder, William S, Rilling, Christopher J, Laing, Clifton M, Tatum, Lawrence R, Kelly, Ricardo D, Garcia-Monaco, Vivek R, Sharma, Todd S, Crocenzi, Steven M, Strasberg
Publikováno v:
Cancer. 121(20)
Reports have demonstrated the superior activity of combining both irinotecan and oxaliplatin (FOLFOXIRI) therapy. An option for gaining similar benefits with less toxicity would be the administration of irinotecan through a hepatic artery approach. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::063c4c787cce682f62a75b995b59e9d5
https://pubmed.ncbi.nlm.nih.gov/26149602
https://pubmed.ncbi.nlm.nih.gov/26149602