Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Marshall S Goodwin"'
Autor:
Brenda D. Moore, Yong Ran, Marshall S. Goodwin, Kavitha Komatineni, Karen N. McFarland, Kristy Dillon, Caleb Charles, Danny Ryu, Xuefei Liu, Stefan Prokop, Benoit I. Giasson, Todd E. Golde, Yona Levites
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101146- (2023)
Enhancing production of protein cargoes delivered by gene therapies can improve efficacy by reducing the amount of vector or simply increasing transgene expression levels. We explored the utility of a 126-amino acid collagen domain (CD) derived from
Externí odkaz:
https://doaj.org/article/6b461f0d9cea453d8528a9ec5184a9ec
Autor:
Cara L. Croft, Giavanna Paterno, Ava R. Vause, Lyla A. Rowe, Daniel H. Ryu, Marshall S. Goodwin, Corey A. Moran, Pedro E. Cruz, Benoit I. Giasson, Todd E. Golde
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract The accumulation of α-synuclein (α-syn) in intracellular formations known as Lewy bodies (LBs) is associated with several neurodegenerative diseases including Parkinson’s disease and Lewy Body Dementia. There is still limited understandi
Externí odkaz:
https://doaj.org/article/e2074e1cbc8644f181214b5c8eb0e8eb
Autor:
Marshall S. Goodwin, Cara L. Croft, Hunter S. Futch, Daniel Ryu, Carolina Ceballos-Diaz, Xuefei Liu, Giavanna Paterno, Catalina Mejia, Doris Deng, Kimberly Menezes, Laura Londono, Kefren Arjona, Mary Parianos, Van Truong, Eva Rostonics, Amanda Hernandez, Sanford L. Boye, Shannon E. Boye, Yona Levites, Pedro E. Cruz, Todd E. Golde
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-16 (2020)
Abstract Background Recombinant adeno-associated virus (rAAV) is widely used in the neuroscience field to manipulate gene expression in the nervous system. However, a limitation to the use of rAAV vectors is the time and expense needed to produce the
Externí odkaz:
https://doaj.org/article/2a178227546947689b7deca1eadc1b03
Autor:
Zachary A. Sorrentino, Marshall S. Goodwin, Cara J. Riffe, Jess-Karan S. Dhillon, Yuxing Xia, Kimberly-Marie Gorion, Niran Vijayaraghavan, Karen N. McFarland, Lawrence I. Golbe, Anthony T. Yachnis, Benoit I. Giasson
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-22 (2019)
Abstract The protein α-synuclein (αsyn) forms pathologic aggregates in a number of neurodegenerative diseases including Lewy body dementia (LBD) and Parkinson’s disease (PD). It is unclear why diseases such as LBD may develop widespread αsyn pat
Externí odkaz:
https://doaj.org/article/7c196ce515fb4cd7b1a8e539e124d090
Autor:
Kevin H. Strang, Marshall S. Goodwin, Cara Riffe, Brenda D. Moore, Paramita Chakrabarty, Yona Levites, Todd E. Golde, Benoit I. Giasson
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-11 (2017)
Abstract Tauopathies are a group of neurodegenerative disorders, including Alzheimer’s disease, defined by the presence of brain pathological inclusions comprised of abnormally aggregated and highly phosphorylated tau protein. The abundance of brai
Externí odkaz:
https://doaj.org/article/2787497578784caa9bdfe0b12cf4e784
Autor:
Veronica O’Neal, Benoit I. Giasson, Olga Sinyavskaya, Todd E. Golde, Peter Davies, Marshall S. Goodwin, Pedro E. Cruz, Franklin Burg, Jada Lewis, Yona Levites, Carolina Ceballos-Diaz
Publikováno v:
Molecular Therapy
Immunotherapies designed to treat neurodegenerative tauopathies that primarily engage extracellular tau may have limited efficacy as tau is primarily intracellular. We generated tau-targeting single-chain variable fragments (scFvs) and intrabodies (i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecbfb4c45d2c988b9042e56f5c23a6dc
http://europepmc.org/articles/PMC7854277
http://europepmc.org/articles/PMC7854277
Autor:
Cara L Croft, Marshall S Goodwin, Daniel H Ryu, Christian B Lessard, Giancarlo Tejeda, Marc Marrero, Ava Vause, Giavanna Paterno, Pedro E Cruz, Jada Lewis, Benoit Giasson, Todd E Golde
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7393a01e16babcc85b9105472dcc667
https://doi.org/10.1002/alz.056366
https://doi.org/10.1002/alz.056366
Autor:
Karen N. McFarland, Kimberly-Marie M. Gorion, Marshall S. Goodwin, Niran Vijayaraghavan, Jess-Karan S. Dhillon, Cara J. Riffe, Zachary A. Sorrentino, Yuxing Xia, Lawrence I. Golbe, Benoit I. Giasson, Anthony T. Yachnis
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-22 (2019)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
The protein α-synuclein (αsyn) forms pathologic aggregates in a number of neurodegenerative diseases including Lewy body dementia (LBD) and Parkinson’s disease (PD). It is unclear why diseases such as LBD may develop widespread αsyn pathology, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d18f9882331b4347f34aac93a330711
http://link.springer.com/article/10.1186/s40478-019-0787-2
http://link.springer.com/article/10.1186/s40478-019-0787-2
Autor:
Pedro E. Cruz, Christopher Janus, Karen A. Scott, Marshall S. Goodwin, Melanie R. Shapiro, Brenda D. Moore, Eric G. Krause, M. Zino Kuhn, Paramita Chakrabarty, Thomas B. Ladd, Andrew Judge, Yong Ran, Todd M. Brusko, Karen N. McFarland, Annette D. de Kloet, Cara L. Croft, Todd E. Golde, Benoit I. Giasson, Daniel Ryu, Yona Levites, Hunter S. Futch, Rachel L. Nosacka
Publikováno v:
The Journal of Experimental Medicine
A high-affinity monoclonal antibody (CTRND05) targeting corticotropin-releasing factor (CRF) blocks stress-induced corticosterone increases, counteracts effects of chronic variable stress, and induces other phenotypes consistent with suppression of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe3b02ddf6c1d5f584f18b771cc69fe
http://europepmc.org/articles/PMC6829597
http://europepmc.org/articles/PMC6829597
Autor:
Todd E. Golde, Marshall S. Goodwin, Jeffery W. Kelly, Yona Levites, Kristopher L. Nazor, Michael R. Sierks, James C. Parker, Nicholas J. Schork, Stuart A. Lipton, Titas Grabauskas, Dorit Trudler, Rajesh Ambasudhan, Michael Karin, Abdullah Sultan, Zhenyu Zhong, Yvonne S. Eisele, Nima Dolatabadi
Publikováno v:
Proc Natl Acad Sci U S A
Parkinson’s disease is characterized by accumulation of α-synuclein (αSyn). Release of oligomeric/fibrillar αSyn from damaged neurons may potentiate neuronal death in part via microglial activation. Heretofore, it remained unknown if oligomeric/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0e710dad40438c0f29b518d65368ba
https://doi.org/10.1073/pnas.2025847118
https://doi.org/10.1073/pnas.2025847118