Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Marshall L. Morningstar"'
Autor:
Daniel E. Neafsey, Dyann F. Wirth, Jon Clardy, Arvind Sharma, Ping S. Lui, Anne-Marie Zeeman, Sean Eckley, Yvonne Van Gessel, Mathias Wawer, Matthias Marti, Elizabeth A. Winzeler, Elamaran Meibalan, Nobutaka Kato, Benito Munoz, Emily R. Derbyshire, Stuart L. Schreiber, Marshall L. Morningstar, Jeremy R. Duvall, Clemens H. M. Kocken, Eli L. Moss, Bennett C. Meier, Joshua A. Bittker, Vicky M. Avery, Manmohan Sharma, John E. Burke, Eamon Comer, Jacob A. McPhail, Maurice A. Itoe, Jessica Bastien, Nicolas M. B. Brancucci, Branko Mitasev, David Clarke, Timothy A. Lewis, Victoria C. Corey, Sandra Duffy, Tomoyo Sakata-Kato, Fabian Gusovsky, Sandra March, Takashi Yoshinaga, Gillian L. Dornan, Flaminia Catteruccia, Morgane Sayes, Emily Lund, Christina Scherer, Sangeeta N. Bhatia, Michael Foley, Amit Sharma, Amanda K. Lukens, Paul A. Clemons, Koen J. Dechering, Karin M. J. Koolen, Micah Maetani
Publikováno v:
Nature
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of action could be discovered using a diverse collection
Autor:
Michael D. Huband, Gunther Kern, Virna J A Schuck, John P. Mueller, Amy Kimzey, Peter Doig, Vincent Galullo, Richard A. Alm, Marshall L. Morningstar, Madhusudhan Gowravaram, John McNulty, Gregory S. Basarab, Kevin Barvian, Manos Perros, Karthick Vishwanathan, Ruben Tommasi, Amy Kutschke, Joseph V. Newman, Kenneth Lawrence, Humphrey Gardner, Grant K. Walkup, Renu Singh, Sushmita D. Lahiri
Publikováno v:
Scientific Reports
With the diminishing effectiveness of current antibacterial therapies, it is critically important to discover agents that operate by a mechanism that circumvents existing resistance. ETX0914, the first of a new class of antibacterial agent targeted f
Publikováno v:
Chemical Research in Toxicology. 10:1345-1350
Spontaneous oxidative DNA damage occurs as a consequence of aerobic metabolism, lipid peroxidation, immune responses, ionizing radiation, and some chemical oxidants. These processes yield a vast array of oxidized DNA bases and sugars. The existence o
Autor:
Mary Elizabeth Peek, Alexander Rich, Susan M. Verghis, Leigh Ann Lipscomb, Marshall L. Morningstar, Elizabeth M. Miller, John M. Essigmann, Loren Dean Williams
Publikováno v:
Proceedings of the National Academy of Sciences. 92:719-723
We have determined the x-ray structure of a DNA fragment containing 7,8-dihydro-8-oxoguanine (G(O)). The structure of the duplex form of d(CCAGOCGCTGG) has been determined to 1.6-A resolution. The results demonstrate that GO forms Watson-Crick base p
Publikováno v:
Proceedings of the National Academy of Sciences. 91:1696-1700
Reaction of synthetic N-(2'-deoxyguanosin-8-yl)-4-aminobiphenyl (dGuo-8-ABP) with t-butoxycarbonyl-L-[35S]methionine, N-hydroxysuccinimidyl ester (35S-labeled TBM-NHS), under optimized conditions produced mono-, bis-, and tris-TBM-acylated nucleoside
Autor:
John M. Essigmann, Michael L. Wood, Marshall L. Morningstar, Asuncion Esteve, Geoffrey M. Kuziemko
Publikováno v:
Nucleic acids research. 20(22)
A single 7,8-dihydro-8-oxoguanine (G8-OXO; 8-hydroxyguanine) adduct in the lacZ alpha gene of bacteriophage M13 DNA induces a targeted G-->T transversion after replication in Escherichia coli (Biochemistry, 29, 7024-7031 (1990)). This mutation is tho
Autor:
Marshall L. Morningstar, Thomas Roth, David W. Farnsworth, Marilyn Kroeger Smith, Karen Watson, Robert W. Buckheit Jr., Kalyan Das, Wanyi Zhang, Eddy Arnold, John G. Julias, Stephen H. Hughes, Christopher J. Michejda
Publikováno v:
Journal of Medicinal Chemistry; Aug2007, Vol. 50 Issue 17, p4003-4015, 13p