Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge.

Autor: Marshall B Elam, Gipsy Majumdar, Khyobeni Mozhui, Ivan C Gerling, Santiago R Vera, Hannah Fish-Trotter, Robert W Williams, Richard D Childress, Rajendra Raghow

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0181308 (2017)

Statins, the 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase inhibitors, are widely prescribed for treatment of hypercholesterolemia. Although statins are generally well tolerated, up to ten percent of statin-treated patients experience myalgia sympt

Externí odkaz: https://doaj.org/article/f656a1c7cac74a59ac6269e67cfb387b

Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk

Autor: Aruna, Das Pradhan, Robert J, Glynn, Jean-Charles, Fruchart, Jean G, MacFadyen, Elaine S, Zaharris, Brendan M, Everett, Stuart E, Campbell, Ryu, Oshima, Pierre, Amarenco, Dirk J, Blom, Eliot A, Brinton, Robert H, Eckel, Marshall B, Elam, João S, Felicio, Henry N, Ginsberg, Assen, Goudev, Shun, Ishibashi, Jacob, Joseph, Tatsuhiko, Kodama, Wolfgang, Koenig, Lawrence A, Leiter, Alberto J, Lorenzatti, Boris, Mankovsky, Nikolaus, Marx, Børge G, Nordestgaard, Dénes, Páll, Kausik K, Ray, Raul D, Santos, Handrean, Soran, Andrey, Susekov, Michal, Tendera, Koutaro, Yokote, Nina P, Paynter, Julie E, Buring, Peter, Libby, Paul M, Ridker, Maureen, McClelland

Publikováno v: Das Pradhan, A, Glynn, R J, Fruchart, J C, MacFadyen, J G, Zaharris, E S, Everett, B M, Campbell, S E, Oshima, R, Amarenco, P, Blom, D J, Brinton, E A, Eckel, R H, Elam, M B, Felicio, J S, Ginsberg, H N, Goudev, A, Ishibashi, S, Joseph, J, Kodama, T, Koenig, W, Leiter, L A, Lorenzatti, A J, Mankovsky, B, Marx, N, Nordestgaard, B G, Páll, D, Ray, K K, Santos, R D, Soran, H, Susekov, A, Tendera, M, Yokote, K, Paynter, N P, Buring, J E, Libby, P & Ridker, P M 2022, ' Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk. ', New England Journal of Medicine, vol. 387, no. 21, pp. 1923-1934 . https://doi.org/10.1056/NEJMoa2210645

Background High triglyceride levels are associated with increased cardiovascular risk, but whether reductions in these levels would lower the incidence of cardiovascular events is uncertain. Pemafibrate, a selective peroxisome proliferator-activated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f084970bad344fb37812ba1fc7407c
https://pubmed.ncbi.nlm.nih.gov/36342123

Contributors

Autor: Luis G. Aguayo, Marium Ahmed, Mohamed H. Ahmed, Musaab Ahmed, Hélio M.T. Albuquerque, Alicia Alonso, Rana Ashkar, Fodil Azzaz, Carlos J. Baier, Francisco J. Barrantes, Małgorzata Bednarska-Makaruk, Andrew S. Bell, Asier Benito-Vicente, Michael F. Brown, Anna N. Bukiya, Carlos F. Burgos, Henri Chahinian, Waranya Chatuphonprasert, Parkson Lee-Gau Chong, Arrigo F.G. Cicero, Ivan R. Cincione, Tatiana M. Clemente, George A. Cook, Zoe Cournia, Coralie Di Scala, Milka Doktorova, Fathima T. Doole, Alex M. Dopico, Alexandros A. Drosos, Hong Du, Marshall B. Elam, Isabella Ellinger, Jacques Fantini, Filipe Ferrari, Unai Galicia-Garcia, Aritz B. García-Arribas, Stacey D. Gilk, Félix M. Goñi, Juliana Gonzalez-Sanmiguel, Gregory A. Grabowski, Sudipta Gupta, Tina Herfel, DanRong Hu, Juyang Huang, Shifa Jebari-Benslaiman, Qiu-Xing Jiang, Samantha Karr, George Khelashvili, Sofia Kiriakidi, Tamas Kovacs, Teshani Kumarage, Claude K. Lardinois, Asier Larrea-Sebal, Irena Levitan, Hanxuan Li, Wei Li, Falk W. Lohoff, Agnieszka Ługowska, Cesar Martin, Vítor M. Martins, Thomas Mavromoustakos, Mark T. Mc Auley, Dushyant Mital, Bob M. Moore, Amy E. Morgan, Ole G. Mouritsen, Steven Mysiewicz, Kelsey C. North, Emma M. O’Connell, Marta Pasenkiewicz-Gierula, ZhiYong Qian, Jorge P. Roa, Avia Rosenhouse-Dantsker, Clementina M.M. Santos, Artur M.S. Silva, Alexandria Slayden, Ghada A. Soliman, Natalia Stein, Ricardo Stein, Witold K. Subczynski, István P. Sugár, Lajos Szente, Kepa B. Uribe, Zoltan Varga, Aliki I. Venetsanopoulou, Paraskevi V. Voulgari, Francine K. Welty, Justyna Widomska, Nouara Yahi, Zdenek Zadak, Florina Zakany

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b40991fd39b691490fd3a3998572c24a
https://doi.org/10.1016/b978-0-323-85857-1.09991-0

Phosphorylation dependent proteostasis of sterol regulatory element binding proteins

Autor: Rajendra Raghow, Qingming Dong, Marshall B. Elam

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1864:1145-1156

Lipid homeostasis is critically dependent on the liver. Hepatic genes involved in lipid biosynthesis are controlled by combinatorial actions of multiple transcription factors that include three sterol regulatory element binding proteins (SREBPs), car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e04db998103013f3377bd3f4770eaf
https://doi.org/10.1016/j.bbalip.2019.04.015

Differential Diagnosis of Statin-Associated Muscle Symptoms

Autor: Marshall B. Elam, Richard D. Childress

Publikováno v: Contemporary Cardiology ISBN: 9783030333034

The differential diagnosis of statin-associated muscle symptoms (SAMS) is challenging in that it mimics a wide range of musculoskeletal disorders. SAMS must be distinguished from fibromyalgia, tendonitis, arthritis, and other causes of musculoskeleta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7bd99a29e053da5d83df0664b56eb33
https://doi.org/10.1007/978-3-030-33304-1_19