Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Marsha R. Rosner"'
Autor:
Michael Tyler Guinn, Yiming Wan, Sarah Levovitz, Dongbo Yang, Marsha R. Rosner, Gábor Balázsi
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/e7518eb25bff4e339c3d3a0f784dc478
Autor:
Ali Ekrem Yesilkanal, Dongbo Yang, Andrea Valdespino, Payal Tiwari, Alan U Sabino, Long Chi Nguyen, Jiyoung Lee, Xiao-He Xie, Siqi Sun, Christopher Dann, Lydia Robinson-Mailman, Ethan Steinberg, Timothy Stuhlmiller, Casey Frankenberger, Elizabeth Goldsmith, Gary L Johnson, Alexandre F Ramos, Marsha R Rosner
Publikováno v:
eLife, Vol 10 (2021)
Metastasis suppression by high-dose, multi-drug targeting is unsuccessful due to network heterogeneity and compensatory network activation. Here, we show that targeting driver network signaling capacity by limited inhibition of core pathways is a mor
Externí odkaz:
https://doaj.org/article/4ff20943f44747458fc45b3108f69f89
Autor:
Long Chi Nguyen, Christopher Dann, Dongbo Yang, Emily Shi, Thomas Li, Joseph Wynne, Letícia Stock, Madeline Henn, Zeyu Qiao, Andrea Valdespino, Raven Watson, Wenchao Liu, Lydia Robinson-Mailman, Galina Khramtsova, Mitsuyo Matsumoto, Raymond Moellering, Olufunmilayo I. Olopade, Kazuhiko Igarashi, Marsha R. Rosner
Publikováno v:
Cancer Research. 83:4807-4807
Hypoxia is an important hallmark of aggressive solid tumors. Here we show that the pro-metastatic BTB and CNC homology 1 (BACH1) transcription factor is prolyl-hydroxylated by the HIF Prolyl Hydroxylase 1 (PHD1) in an oxygen-dependent manner. Using m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a23e4937d1431c7dd680c9bd8fb24f14
https://doi.org/10.1158/1538-7445.am2023-4807
https://doi.org/10.1158/1538-7445.am2023-4807
Autor:
Leticia Stock, Lydia Robinson-Mailman, Long C. Nguyen, Shao-Nong Chen, Guido F. Pauli, Marsha R. Rosner
Publikováno v:
Cancer Research. 83:793-793
CBD, an FDA approved drug for epilepsy, may have therapeutic potential for other diseases and is currently being tested for efficacy in cancer-related clinical trials. As the literature about CBD, especially in vitro reports, is often contradictory,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff749974677e20c46c3f2ccffcd32d4a
https://doi.org/10.1158/1538-7445.am2023-793
https://doi.org/10.1158/1538-7445.am2023-793
Autor:
Christopher M. Dann, Long C. Nguyen, Dongbo Yang, Joseph P. Wynne, Andrea Valdespino, Letícia Stock, Marsha R. Rosner
Publikováno v:
Cancer Research. 82:118-118
Triple-negative breast cancer (TNBC) is an aggressive solid tumor characterized by a hypoxic phenotype that promotes metastatic progression and resistance to therapy. The canonical cellular response to hypoxia is largely driven by hypoxia inducible f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea7c22c571a3d868169b623e4e70b482
https://doi.org/10.1158/1538-7445.am2022-118
https://doi.org/10.1158/1538-7445.am2022-118
Autor:
Olga Martinho, Sara Granja, Teresa Jaraquemada, Cláudia Caeiro, Vera Miranda-Gonçalves, Mrinalini Honavar, Paulo Costa, Margarida Damasceno, Marsha R Rosner, José M Lopes, Rui M Reis
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30769 (2012)
Malignant gliomas are highly infiltrative and invasive tumors, which precludes the few treatment options available. Therefore, there is an urgent need to elucidate the molecular mechanisms underlying gliomas aggressive phenotype and poor prognosis. T
Externí odkaz:
https://doaj.org/article/8803d99e3c3848b6869eb5ce816134e8
Autor:
Anne N Shemon, Gary L Heil, Alexey E Granovsky, Mathew M Clark, Dan McElheny, Alexander Chimon, Marsha R Rosner, Shohei Koide
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10479 (2010)
BackgroundRaf kinase inhibitory protein (RKIP), also known as phoshaptidylethanolamine binding protein (PEBP), has been shown to inhibit Raf and thereby negatively regulate growth factor signaling by the Raf/MAP kinase pathway. RKIP has also been sho
Externí odkaz:
https://doaj.org/article/599a1f1f544e4bb28a7ae4ba60f27bbd
Autor:
Daniel C. Rabe, Casey Frankenberger, Russell Bainer, Devipriya Sankarasharma, Kiran Chada, Thomas Krausz, Yoav Gilad, Lev Becker, Marsha R. Rosner
Publikováno v:
Cancer Research. 75:5077-5077
Triple-negative breast cancer (TNBC) patients have the highest risk of recurrence and metastasis. Because they cannot be treated with targeted therapies, and many do not respond to chemotherapy, they represent a clinically underserved group. While ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17543ef29dbc2c75e111ae91ec31e6df
https://doi.org/10.1158/1538-7445.am2015-5077
https://doi.org/10.1158/1538-7445.am2015-5077
Publikováno v:
Molecular cell. 21(4)
Ultraviolet (UV) exerts its biological activities by activating downstream effectors, including NF-kappaB, JNK, and caspases. Activation of JNK is required for UV-induced apoptosis. It is unknown whether any crosstalk occurs between NF-kappaB and JNK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::340acee049ebbc9d4fb77ec3ab636c08
https://pubmed.ncbi.nlm.nih.gov/16483929
https://pubmed.ncbi.nlm.nih.gov/16483929
Autor:
Subbiah, Pugazhenthi, Albina, Nesterova, Purevsuren, Jambal, Gerald, Audesirk, Marcey, Kern, Leigh, Cabell, Eva, Eves, Marsha R, Rosner, Linda M, Boxer, Jane E-B, Reusch
Publikováno v:
Journal of neurochemistry. 84(5)
Generation of oxidative stress/reactive oxygen species (ROS) is one of the causes of neuronal apoptosis. We have examined the effects of ROS at the transcriptional level in an immortalized hippocampal neuronal cell line (H19-7) and in rat primary hip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5cd6b5f49b35bc79cbeb1a5ed915903
https://pubmed.ncbi.nlm.nih.gov/12603823
https://pubmed.ncbi.nlm.nih.gov/12603823