Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Marsha R. Eno"'
Autor:
Nikolai Zvonok, Ken Mackie, Han Zhou, Spyros P. Nikas, Demetris P. Papahatjis, Andrea G. Hohmann, JodiAnne T. Wood, Shu Xu, Simiao Wu, Lipin Ji, Patricia H. Reggio, Marsha R. Eno, Lawrence J. Marnett, Khadijah A. Mohammad, Paula Morales, Yingpeng Liu, Ai-Ling Li, Dow P. Hurst, Shalley N. Kudalkar, Alexandros Makriyannis, Chandrashekhar Honrao, Othman Benchama, Marion Schimpgen
Publikováno v:
Journal of Medicinal Chemistry. 61:8639-8657
The synthesis of potent metabolically stable endocannabinoids is challenging. Here we report a chiral arachidonoyl ethanolamide (AEA) analogue, namely, (13S,1′R)-dimethylanandamide (AMG315, 3a), a high affinity ligand for the CB1 receptor (Ki of 7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a1b3b68c754e7acf2b4084786b9971
https://doi.org/10.1021/acs.jmedchem.8b00611
https://doi.org/10.1021/acs.jmedchem.8b00611
Publikováno v:
Chemical Research in Toxicology. 29:784-796
Lapatinib (LAP), an oral tyrosine kinase inhibitor for the treatment of metastatic breast cancer, has been associated with idiosyncractic hepatotoxicity. Recent investigations have implicated the importance of P450 3A4/5 enzymes in the formation of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20122734704d7c8252378ab46931c8b2
https://doi.org/10.1021/acs.chemrestox.5b00524
https://doi.org/10.1021/acs.chemrestox.5b00524
Autor:
Shu Xu, Spyros P. Nikas, Lawrence J. Marnett, Marsha R. Eno, Surajit Banerjee, Carol A. Rouzer, Shalley N. Kudalkar, Lipin Ji, Philip J. Kingsley, Alexandros Makriyannis, James J. Galligan
Publikováno v:
Journal of Biological Chemistry. 290:7897-7909
Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid (AA) and the endocannabinoids 2-arachidonoylglycerol (2-AG) and arachidonylethanolamide to prostaglandins, prostaglandin glyceryl esters, and prostaglandin ethanolamides, respectively. A structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31780fca549c8b0d079e5bf2e8ff29a0
https://doi.org/10.1074/jbc.m114.634014
https://doi.org/10.1074/jbc.m114.634014
Autor:
Ganeshsingh A. Thakur, Alexandros Makriyannis, Keith A. Sharkey, Alex Straiker, Catherine M. Keenan, Mohammad Bashashati, Ken Mackie, Marsha R. Eno, JodiAnne T. Wood, Martin Storr, Jim Wager-Miller, Huang-Ming Hu, Spyridon P. Nikas
Publikováno v:
British Journal of Pharmacology. 172:2406-2418
Background and Purpose Cannabinoid (CB) ligands have been demonstrated to have utility as novel therapeutic agents for the treatment of pain, metabolic conditions and gastrointestinal (GI) disorders. However, many of these ligands are centrally activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0230a556852ffb7f874ec57ec3faeca8
https://doi.org/10.1111/bph.13069
https://doi.org/10.1111/bph.13069
Autor:
Marsha R. Eno, Michael D. Cameron
Publikováno v:
Current Medicinal Chemistry. 22:465-489
Over the past decades, it has become abundantly clear that enzymes evolved to detoxify and eliminate foreign chemicals from the body, occasionally generate highly reactive metabolites which have toxicological implications. To decrease the probability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779211f46b3e307f23f9d8e166b5589b
https://doi.org/10.2174/0929867321666140826113520
https://doi.org/10.2174/0929867321666140826113520
Albumin-oxanorbornadiene conjugates formed ex vivo for the extended circulation of hydrophilic cargo
Oxanorbornadiene dicarboxylate (OND) reagents were explored for the purpose of binding and releasing chemical cargos from endogenous circulating serum albumins. ONDs bearing gadolinium chelates as model cargos exhibited variable conjugation efficienc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5097323467af9ee580da094b1adb8185
https://europepmc.org/articles/PMC5523132/
https://europepmc.org/articles/PMC5523132/
