Výsledky vyhledávání - "Marsha L. Fox"

Association of Cyclooxygenase-1-Dependent and -Independent Platelet Function Assays With Adverse Clinical Outcomes in Aspirin-Treated Patients Presenting for Cardiac Catheterization

Autor: Andrew L. Frelinger, YouFu Li, Marc R. Barnard, Marsha L. Fox, Mark I. Furman, Douglas J. Christie, Matthew D. Linden, Alan D. Michelson

Publikováno v: Circulation. 120:2586-2596

Background— Poor clinical outcome in aspirin-treated patients has been termed aspirin resistance and may result from inadequate inhibition of platelet cyclooxygenase-1 (COX-1) by aspirin. The objectives of this study were to determine prospectively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683dd041a7f1299038560959abb9439f
https://doi.org/10.1161/circulationaha.109.900589

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The active metabolite of prasugrel inhibits adenosine diphosphate- and collagen-stimulated platelet procoagulant activities

Autor: YouFu Li, Marc R. Barnard, Joseph A. Jakubowski, Inge Tarnow, Alan D. Michelson, Mark I. Furman, Marsha L. Fox, Matthew D. Linden, Kenneth J. Winters, Atsuhiro Sugidachi, Andrew L. Frelinger

Publikováno v: Journal of Thrombosis and Haemostasis. 6:359-365

Summary. Background: Prasugrel is a novel antiplatelet prodrug of the same thienopyridine class as clopidogrel and ticlopidine. Metabolism of prasugrel generates the active metabolite R-138727, an antagonist of the platelet P2Y12 adenosine diphosphat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed30d29752db995e147e7a1ebe2c24a9
https://doi.org/10.1111/j.1538-7836.2007.02838.x

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Cystic fibrosis heterozygotes do not have increased platelet activation

Autor: Alan D. Michelson, Marsha L. Fox, Andrew L. Frelinger, Inge Tarnow, Brian O'Sullivan, YouFu Li, Marc R. Barnard, Matthew D. Linden

Publikováno v: Thrombosis Research. 121:159-162

Introduction: We have previously demonstrated platelet hyperreactivity in cystic fibrosis (CF) patients. Carriers of one CF mutation (heterozygotes) have been shown to have abnormalities related to the presence of only one-half the normal amount of C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bb846ad4f595431da4519a17735b83
https://doi.org/10.1016/j.thromres.2007.04.004

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Evidence that pre‐existent variability in platelet response to ADP accounts for ‘clopidogrel resistance’

Autor: YouFu Li, Marsha L. Fox, Mark I. Furman, Thomas J. McLaughlin, W. C. Lau, Marc R. Barnard, Alan D. Michelson, Matthew D. Linden, Andrew L. Frelinger

Publikováno v: Journal of Thrombosis and Haemostasis. 5:75-81

Summary. Background: Clopidogrel is a widely used antithrombotic agent that inhibits the platelet P2Y12 adenosine diphosphate (ADP) receptor. There is increasing interest in ‘clopidogrel resistance’. Objectives: To determine whether ‘clopidogre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33468a47eeb6581a8bf875cd1a9cec79
https://doi.org/10.1111/j.1538-7836.2006.02234.x

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The active metabolite of prasugrel inhibits ADP-stimulated thrombo-inflammatory markers of platelet activation: Influence of other blood cells, calcium, and aspirin

Autor: Andrew L. Frelinger, Mark I. Furman, Marc R. Barnard, Atsuhiro Sugidachi, YouFu Li, Alan D. Michelson, Marsha L. Fox, Joseph A. Jakubowski, Kenneth J. Winters, Matthew D. Linden

Publikováno v: Thrombosis and Haemostasis. 98:192-200

SummaryThe novel thienopyridine prodrug prasugrel, a platelet P2Y12 ADP receptor antagonist, requires in vivo metabolism for activity. Although pharmacological data have been collected on the effects of prasugrel on platelet aggregation,there are few

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1cfc4d345047969c631e280882386ee3
https://doi.org/10.1160/th07-01-0010

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Residual Arachidonic Acid–Induced Platelet Activation via an Adenosine Diphosphate–Dependent but Cyclooxygenase-1– and Cyclooxygenase-2–Independent Pathway

Autor: Marsha L. Fox, Mark I. Furman, YouFu Li, Matthew D. Linden, Andrew L. Frelinger, Alan D. Michelson, Marc R. Barnard

Publikováno v: Circulation. 113:2888-2896

Background— Thrombotic events still occur in aspirin-treated patients with coronary artery disease. Methods and Results— To better understand aspirin “resistance,” serum thromboxane B 2 (TXB 2 ) and flow cytometric measures of arachidonic aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aeb7e1821cc39141cd5c889f0aeb53e
https://doi.org/10.1161/circulationaha.105.596627

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Effects of platelet binding on whole blood flow cytometry assays of monocyte and neutrophil procoagulant activity

Autor: Marsha L. Fox, Alan D. Michelson, Mark I. Furman, Marc R. Barnard, YouFu Li, Andrew L. Frelinger, Matthew D. Linden

Publikováno v: Journal of Thrombosis and Haemostasis. 3:2563-2570

Summary. Background: Monocytes and neutrophils form heterotypic aggregates with platelets initially via engagement of platelet surface P-selectin with leukocyte surface P-selectin glycoprotein ligand-1 (PSGL-1). The resultant intracellular signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17cce514dffb5dba2ff48c63cc851b88
https://doi.org/10.1111/j.1538-7836.2005.01603.x

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The Platelet Activity After Clopidogrel Termination (PACT) study

Autor: Andrew L. Frelinger, Marc R. Barnard, Alan D. Michelson, Marsha L. Fox

Publikováno v: Circulation. Cardiovascular interventions. 3(5)

Background— “Rebound” platelet hyperreactivity after discontinuation of clopidogrel has been proposed to lead to increased thrombotic risk, including late stent thrombosis. However the hypothesis that discontinuation of clopidogrel results in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169143921b4a4db33b59022f1fb624dd
https://pubmed.ncbi.nlm.nih.gov/20736449

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Response to Letter Regarding Article, 'Association of Cyclooxygenase-1–Dependent and –Independent Platelet Function Assays With Adverse Clinical Outcomes in Aspirin-Treated Patients Presenting for Cardiac Catheterization'

Autor: Andrew L. Frelinger, Marc R. Barnard, YouFu Li, Marsha L. Fox, Douglas J. Christie, Matthew D. Linden, Mark I. Furman, Alan D. Michelson

Publikováno v: Circulation. 122

Our conclusion that “poor clinical outcomes of aspirin-treated patients is due in part to incomplete cyclooxygenase-1 (COX-1) inhibition, but is also due in part to COX-1–independent platelet hyperreactivity” is based on the independent associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e06794c208c6d1582dbc9d3601b6b104
https://doi.org/10.1161/circulationaha.110.951871

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