Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress.

Autor: Chen-Hua Chuang, Marsha D Wallace, Christian Abratte, Teresa Southard, John C Schimenti

Publikováno v: PLoS Genetics, Vol 6, Iss 9, p e1001110 (2010)

Mutations causing replication stress can lead to genomic instability (GIN). In vitro studies have shown that drastic depletion of the MCM2-7 DNA replication licensing factors, which form the replicative helicase, can cause GIN and cell proliferation

Externí odkaz: https://doaj.org/article/c509e80d8f10423e911350166c8b30e2

Supplementary Data from Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response

Autor: Gareth L. Bond, Hannah Carter, Clare Turnbull, Ian Tomlinson, Enric Domingo, Timothy S. Maughan, Sarah P. Blagden, Meghana Pagadala, Daniel V. Ebner, Val Millar, Andrew Protheroe, Claire Palles, Lukasz F. Grochola, Rick Jansen, Chey Loveday, Paul D. Pharoah, Siddhartha Kar, Janet Shipley, Joanna L. Selfe, Anderson J. Ryan, Yanyan Jiang, Jorge Zeron-Medina, Douglas A. Bell, Xuting Wang, David Sims, Mirvat Surakhy, Sarah De Val, Svanhild Nornes, Samantha Moore, Natasha Sahgal, Elisabeth Bond, Marsha D. Wallace, Philipp H. Richter, Katherine Brown, Giovanni Stracquadanio, Lingyun Xiong, Isaac Kitchen-Smith, Ping Zhang

Supplementary Methods; Supplementary Figures S1-S5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c5eb435e059e37b7df5dbe2572af66
https://doi.org/10.1158/0008-5472.22429038.v1

Corrigendum: MEF2 transcription factors are key regulators of sprouting angiogenesis

Autor: Natalia Sacilotto, Kira M. Chouliaras, Leonid L. Nikitenko, Yao Wei Lu, Martin Fritzsche, Marsha D. Wallace, Svanhild Nornes, Fernando García-Moreno, Sophie Payne, Esther Bridges, Ke Liu, Daniel Biggs, Indrika Ratnayaka, Shane P. Herbert, Zoltán Molnár, Adrian L. Harris, Benjamin Davies, Gareth L. Bond, George Bou-Gharios, John J. Schwarz, Sarah De Val

Publikováno v: Genesdevelopment. 36(19-20)

In this study, Saccilotto et al. investigated the molecular connection between proangiogenic signals and downstream gene expression during angiogenesis. By characterizing a Dll4 enhancer directing expression to endothelial cells at the angiogenic fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3994d7d30ddb18fe80c57a25341e41fe
https://pubmed.ncbi.nlm.nih.gov/27898394

Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression, and drug response

Autor: Ping Zhang, Enric Domingo, Daniel Ebner, Marsha D. Wallace, Natasha Sahgal, Hannah Carter, Andrew Protheroe, Philipp Harald Richter, Paul D.P. Pharoah, Janet Shipley, Val Millar, Lingyun Xiong, Katherine A. Brown, Rick Jansen, Svanhild Nornes, Jorge Zeron-Medina, Anderson J. Ryan, Ian Tomlinson, Joanna Selfe, Isaac Kitchen-Smith, Elisabeth E. Bond, Sarah P. Blagden, Chey Loveday, David Sims, Sarah De Val, Tim Maughan, Douglas A. Bell, Samantha Moore, Gareth L. Bond, Meghana Pagadala, Yanyan Jiang, Claire Palles, Giovanni Stracquadanio, Siddhartha Kar, Xuting Wang, Mirvat Surakhy, Clare Turnbull, Lukasz Filip Grochola

Publikováno v: Cancer Res
Cancer Research, 81(7), 1667-1680. American Association for Cancer Research Inc.
Cancer research, vol 81, iss 7
Zhang, P, Kitchen-Smith, I, Xiong, L, Stracquadanio, G, Brown, K, Richter, P, Wallace, M, Bond, E, Sahgal, N, Moore, S, Nornes, S, De Val, S, Surakhy, M, Sims, D, Wang, X, Bell, D A, Zeron-Medina, J, Jiang, Y, Ryan, A, Selfe, J, Shipley, J, Kar, S, Pharoah, P, Loveday, C, Jansen, R, Grochola, L F, Palles, C, Protheroe, A, Millar, V, Ebner, D, Pagadala, M, Blagden, S P, Maughan, T, Domingo, E, Tomlinson, I P M, Turnbull, C, Carter, H & Bond, G L 2021, ' Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression and drug response ', Cancer Research . https://doi.org/10.1158/0008-5472.CAN-20-0177
Zhang, P, Kitchen-Smith, I, Xiong, L, Stracquadanio, G, Brown, K, Richter, P H, Wallace, M D, Bond, E, Sahgal, N, Moore, S, Nornes, S, De Val, S, Surakhy, M, Sims, D, Wang, X, Bell, D A, Zeron-Medina, J, Jiang, Y, Ryan, A J, Selfe, J L, Shipley, J, Kar, S, Pharoah, P D P, Loveday, C, Jansen, R, Grochola, L F, Palles, C, Protheroe, A, Millar, V, Ebner, D V, Pagadala, M, Blagden, S P, Maughan, T S, Domingo, E, Tomlinson, I, Turnbull, C, Carter, H & Bond, G L 2021, ' Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression, and drug response ', Cancer Research, vol. 81, no. 7, pp. 1667-1680 . https://doi.org/10.1158/0008-5472.CAN-20-0177

Insights into oncogenesis derived from cancer susceptibility loci (SNP) hold the potential to facilitate better cancer management and treatment through precision oncology. However, therapeutic insights have thus far been limited by our current lack o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3484e3e3aa599b5ecb1278c95e8894
https://ora.ox.ac.uk/objects/uuid:5e165644-cc00-4d74-8fff-6e62725c1cfc

Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress

Autor: John C. Schimenti, Teresa L. Southard, Marsha D. Wallace, Kerry J. Schimenti

Publikováno v: Oncogene

Defective DNA replication can result in genomic instability, cancer and developmental defects. To understand the roles of DNA damage response (DDR) genes on carcinogenesis in mutants defective for core DNA replication components, we utilized the Mcm4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d3f900b401a7f45a233db64f06a70b
https://doi.org/10.1038/onc.2013.339